59797-06-7

Usage

Classification

Natural stimulant and psychoactive drug

Occurrence

Commonly found in coffee, tea, and energy drinks

Mechanism of Action

Blocks the action of the neurotransmitter adenosine, which promotes relaxation and sleep

Effects

Increased alertness, improved cognitive function, and reduced fatigue

Additional Properties

Diuretic properties, making it a common ingredient in weight loss supplements

Potential Side Effects

Anxiety, palpitations, and insomnia due to excessive consumption

Popularity

Widely consumed and enjoyed for its stimulating effects

Upstream product

• 115893-52-2 1,3,7-trimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid 
• 78-94-4 methyl vinyl ketone 
• 17743-04-3 1,3-dimethyl-6-iminouracil 
• 88628-96-0 1,3-dimethyl-6-(α-methylallyl)aminouracil 
• 67-64-1 acetone 
• 36980-91-3 1,3-dimethyl-5-cyanouracil 
• 54947-92-1 morpholino-2 propene 
• 181465-38-3 6-amino-1,3-dimethyl-5-thioformyluracil 
• 6642-31-5 6-Amino-1,3-dimethylbarbituric acid 
• 22412-89-1 cycloocta-2,4,6-trien-1-one 
• 64-19-7 acetic acid 
• 99747-54-3 1,3-dimethyl-2,4-dioxo-6-<(triphenylphosphoranylidene)amino>-1,2,3,4-tetrahydropyrimidine 
• 6972-27-6 1,3-Dimethyl-6-chlorouracil 

Relevant academic research and scientific papers

On the reactions of 6-phosphoranylideneaminouracils and related 6-aminouracils with 2,4,6-cyclooctatrienone: Reactions of the intermediates of uracil-annulated 8-azabicyclo[5.3.1]Undecatetraene ring systems

The reaction of 1,3-dimethyl-6-phosphoranylideneaminouracil (4) with 2,4,6-cyclooctatrienone (7) in AcOH gives an intermediacy of uracil-annulated 8-azabicyclo[5.3.1]undeca-2,4,7,9-tetraene (9), which results in the formation of 9-acetoxy-5a, 10-methano-2

Carbon transfer reactions of functionalized oxazolidines and their open chain enamine tautomers to enamine nucleophiles. A facile synthesis of substituted pyridines and ring annulated derivatives

Oxazolidines substituted at C-2 with -CH2-EW(-CO-, etc.) and capable of existing as ring-chain (enamine) tautomers react with cyclic, acyclic and heterocyclic enamine derivatives in a 1:1 stoi-chiometric manner to provide a versatile synthesis of substituted pyridines and their ring annulated derivatives.

A SIMPLE SYNTHESIS OF 1,3-DIALKYLPYRIDOPYRIMIDINES

A novel and simplified synthesis of 1,3-dialkylpyridopyrimidine-2,4(1H,3H)-diones from 6-allylamino- and 6-(substituted allyl)aminouracils by PdCl2-CuCl catalyzed oxidative cyclization is described.

Pyrimidines. 20. Novel Reactions of 5-Cyano-1,3-dimethyluracil. A Simple Synthesis of Pyridopyrimidines

A reaction of 5-cyano-1,3-dimethyluracil (1, R = CN) with acetone in base afforded 1,3,7-trimethylpyridopyrimidine-2,4(1H,3H)-dione (9a) in a moderate yield.From a reaction mixture of 1 (R = CN) with butanone, 1,3,6,7-tetramethyl- and 7-ethyl-1,3-dimethylpyridopyrimidine-2,4(1H,3H)-dione (9b and 9c, respectively) were isolated in low yields.When ethyl cyanoacetate or malononitrile was used in place of the ketone in the above reaction, 7-amino-6-ethoxycarbonyl- and 7-amino-6-cyano-1,3-dimethylpyridopyrimidine-2,4(1H,3H)-dione (14a and 14b, respectively) were obtained in quantitative yields.A plausible mechanism for the formation of bicyclic compounds is discussed.

Synthesis of Heterocycles : Part IV - Pyridopyrimidines

5,7-Disubstituted pyridopyrimidine-2,4-diones (Va-c) have been synthesized by a new route involving Michael addition of 1,3-dimethyl-6-iminouracil (I) to α-enones (IIa-c).Reaction of I and benzalacetone (IId) furnishes 9H-pyrimido-quinoline derivatives (VI, VII).