603126-57-4

Basic information

• Product Name: Cyclopentanone, 2-phenyl-2-[(trimethylsilyl)oxy]-
• CAS NO: 603126-57-4
• Molecular Formula: C14H20O2Si
• Molecular Weight: 248.397
• Mol File: 603126-57-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Cyclopentanone, 2-phenyl-2-[(trimethylsilyl)oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopentanone, 2-phenyl-2-[(trimethylsilyl)oxy]-(603126-57-4)
• EPA Substance Registry System: Cyclopentanone, 2-phenyl-2-[(trimethylsilyl)oxy]-(603126-57-4)

Safety Data

• Hazardous Substances Data: 603126-57-4(Hazardous Substances Data)

Upstream product

• 1501-05-9 5-oxo-5-phenylvaleric acid 
• 10413-00-0 5-oxo-5-phenylpentanenitrile 
• 5415-48-5 2-benzoyl-4-cyano-butyric acid ethyl ester 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 870262-27-4 1-imidazol-1-yl-5-phenyl-pentane-1,5-dione 
• 75-77-4 chloro-trimethyl-silane 
• 1501-04-8 Methyl 4-benzoylbutanoate 

Downstream Products

• 1198-34-1 2-Phenylcyclopentanone 
• 40297-30-1 2-Hydroxy-2-phenylcyclopentan-1-one 

Relevant articles and documents

Enantioselective titanium(III)-catalyzed reductive cyclization of ketonitriles

Reduction, please! The title reaction affords ?-hydroxyketones, a common structural motif in biologically active natural products, in good yields and high enantioselectivities at room temperature. The commercially available ansa-titanocene 1 was found to be an efficient catalyst for this process, which presumably proceeds by addition of a ketyl radical to a nitrile.

Electroreductive acylation of aromatic ketones with acylimidazoles

The intermolecular reductive coupling of aromatic ketones with acylimidazoles was effected by electroreduction in the presence of chlorotrimethylsilane and gave α-trimethylsiloxy ketones and esters. The best result was obtained using Bu4NPF6 as a supporting electrolyte and a Pb cathode in THF. The α-trimethylsiloxy-containing products were transformed to the corresponding α-hydroxy ketones and esters by treatment with TBAF in THF. This method was also effective for the intramolecular reductive coupling of δ- and ε-keto acylimidazoles.