607-94-3

Usage

InChI:InChI=1/C8H6Cl3NO/c1-4(13)12-8-6(10)2-5(9)3-7(8)11/h2-3H,1H3,(H,12,13)

Upstream product

• 533-17-5 N-(2-chlorophenyl)acetamide 
• 539-03-7 N-(4-chlorophenyl)acetamide 
• 75-36-5 acetyl chloride 
• 634-93-5 2,4,6-trichloroaniline 
• 103-84-4 Acetanilid 
• 2754-27-0 trimethylsilyl acetate 
• 103-88-8 4-bromoacetanilide 
• 29551-85-7 N-chloro-p-chloroacetanilide 
• 112160-74-4 acetic acid-(2,4,N-trichloro-anilide) 
• 64-19-7 acetic acid 
• 824391-85-7 N-(2,4,6-trichloro-phenyl)-malonamic acid 
• 6975-29-7 N-(2,4-dichlorophenyl)acetamide 
• 824391-87-9 N-(2,4,6-trichloro-phenyl)-malonamic acid ethyl ester 

Downstream Products

• 27876-29-5 acetic acid-(2,4,6,N-tetrachloro-anilide) 
• 10266-28-1 acetic acid-(N-bromo-2,4,6-trichloro-anilide) 
• 42740-46-5 acetic acid-(2,4,6-trichloro-3-nitro-anilide) 
• 62248-09-3 2,4,6-Trichlorothioacetanilide 
• 5326-26-1 5,7-dichloro-2-phenyl-1H-indole 
• 684250-13-3 5,7-dichloro-2-(4-methoxyphenyl)-1H-indole 

Relevant academic research and scientific papers

Chlorination Reaction of Aromatic Compounds and Unsaturated Carbon-Carbon Bonds with Chlorine on Demand

Chlorination with chlorine is straightforward, highly reactive, and versatile, but it has significant limitations. In this Letter, we introduce a protocol that could combine the efficiency of electrochemical transformation and the high reactivity of chlorine. By utilizing Cl3CCN as the chloride source, donating up to all three chloride atom, the reaction could generate and consume the chlorine in situ on demand to achieve the chlorination of aromatic compounds and electrodeficient alkenes.

Oxidative chlorination of acetanilides by metal chlorides-hydrogen peroxide in acid-aqueous medium systems

The reaction of chlorination of acetanilides by systems: metal chlorides - hydrogen peroxide in acid-water medium gives the chlorosubstituted acetanilides in good yield.

An Effective Method for Acylation of Weakly Nucleophilic Anilines with Silyl Carboxylates via Mixed Anhydrides

In the presence of a catalytic amount of active titanium(IV) salt generated in situ from 1 mol of TiCl4 and 2 mol of AgOTf, weakly nucleophilic anilines react under mild conditions with nearly equimolar amounts of silyl carboxylates to afford the corresponding anilides in excellent yields using 4-(trifluoromethyl)benzoic anhydride.The mixed anhydride formed in situ from trimethylsilyl acetate and 4-(trifluoromethyl)benzoic anhydride, a key intermediate of this reaction, was detected by 1H NMR experiment.Further, it was shown that the reaction of the mixed anhydrides and 2-nitroaniline was faster than that of the corresponding homo anhydrides and 2-nitroaniline.

A Convenient Synthesis of Carboxanilides from Silyl Carboxylates and Weakly Nucleophilic Anilines Using p-Trifluoromethylbenzoic Anhydride and a Catalytic Amount of Active Titanium(IV) Salt

Various carboxanilides are prepared in excellent yields from nearly equimolar amounts of silyl carboxylates and the corresponding weakly nucleophilic anilines under mild conditions by using p-trifluoromethylbenzoic anhydride and a catalytic amount of active titanium(IV) salt.