607-94-3

Basic information

• Product Name: N-(2,4,6-Trichlorophenyl)acetamide
• Synonyms: 2',4',6'-Trichloroacetanilide;N-(2,4,6-Trichlorophenyl)acetamide
• CAS NO: 607-94-3
• Molecular Formula: C₈H₆Cl₃NO
• Molecular Weight: 238.49834
• Mol File: 607-94-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 368.6°Cat760mmHg
• Flash Point: 176.7°C
• Appearance: /
• Density: 1.505g/cm³
• Vapor Pressure: 1.26E-05mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: N-(2,4,6-Trichlorophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4,6-Trichlorophenyl)acetamide(607-94-3)
• EPA Substance Registry System: N-(2,4,6-Trichlorophenyl)acetamide(607-94-3)

Safety Data

• Hazardous Substances Data: 607-94-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H6Cl3NO/c1-4(13)12-8-6(10)2-5(9)3-7(8)11/h2-3H,1H3,(H,12,13)

Upstream product

• 103-84-4 Acetanilid 
• 103-88-8 4-bromoacetanilide 
• 634-93-5 2,4,6-trichloroaniline 
• 824391-87-9 N-(2,4,6-trichloro-phenyl)-malonamic acid ethyl ester 
• 29551-85-7 N-chloro-p-chloroacetanilide 
• 2754-27-0 trimethylsilyl acetate 
• 75-36-5 acetyl chloride 
• 539-03-7 N-(4-chlorophenyl)acetamide 
• 112160-74-4 acetic acid-(2,4,N-trichloro-anilide) 
• 64-19-7 acetic acid 
• 824391-85-7 N-(2,4,6-trichloro-phenyl)-malonamic acid 
• 6975-29-7 N-(2,4-dichlorophenyl)acetamide 
• 533-17-5 N-(2-chlorophenyl)acetamide 

Downstream Products

• 684250-13-3 5,7-dichloro-2-(4-methoxyphenyl)-1H-indole 
• 5326-26-1 5,7-dichloro-2-phenyl-1H-indole 
• 62406-71-7 2,4,6-trichloro-3-nitro-aniline 
• 62248-12-8 4,6-dichloro-2-methyl-benzothiazole 
• 42740-46-5 acetic acid-(2,4,6-trichloro-3-nitro-anilide) 
• 62715-81-5 2,4,6-trichloro-diacetanilide 

Relevant articles and documents

Chlorination Reaction of Aromatic Compounds and Unsaturated Carbon-Carbon Bonds with Chlorine on Demand

Chlorination with chlorine is straightforward, highly reactive, and versatile, but it has significant limitations. In this Letter, we introduce a protocol that could combine the efficiency of electrochemical transformation and the high reactivity of chlorine. By utilizing Cl3CCN as the chloride source, donating up to all three chloride atom, the reaction could generate and consume the chlorine in situ on demand to achieve the chlorination of aromatic compounds and electrodeficient alkenes.

An Effective Method for Acylation of Weakly Nucleophilic Anilines with Silyl Carboxylates via Mixed Anhydrides

In the presence of a catalytic amount of active titanium(IV) salt generated in situ from 1 mol of TiCl4 and 2 mol of AgOTf, weakly nucleophilic anilines react under mild conditions with nearly equimolar amounts of silyl carboxylates to afford the corresponding anilides in excellent yields using 4-(trifluoromethyl)benzoic anhydride.The mixed anhydride formed in situ from trimethylsilyl acetate and 4-(trifluoromethyl)benzoic anhydride, a key intermediate of this reaction, was detected by 1H NMR experiment.Further, it was shown that the reaction of the mixed anhydrides and 2-nitroaniline was faster than that of the corresponding homo anhydrides and 2-nitroaniline.