60839-94-3Relevant academic research and scientific papers
Fluoromethylated derivatives of carnitine biosynthesis intermediates- synthesis and applications
Rydzik, Anna M.,Leung, Ivanhoe K. H.,Thalhammer, Armin,Kochan, Grazyna T.,Claridge, Timothy D. W.,Schofield, Christopher J.
, p. 1175 - 1177 (2014)
A convenient method for the synthesis of fluoromethylated carnitine biosynthesis intermediates, i.e. fluorinated derivatives of γ- butyrobetaine and trimethyllysine, is described. The fluoromethylated probes were useful in both in vitro and cell based ass
Fluoro-Pummerer rearrangement under oxidative desulfurization fluorination conditions. Facile synthesis of oligofluoroalkyl sulfides
Furuta, Satoru,Kuroboshi, Manabu,Hiyama, Tamejiro
, p. 8243 - 8246 (1995)
Upon treatment with n-Bu4NH2F3 and 1,3-dibromo-5,5-dimethylhydantoin, various organic sulfides were readily fluorinated to give α-fluoro sulfides. When (HF)9-Py was used as the fluorinating agent, normal oxidative desulfurization fluorination occurred depending on the structure of the substrates.
[18F]Fluoromethyl iodide ([18F]FCH2I): Preparation and reactions with phenol, thiophenol, amide and amine functional groups
Zhang, Ming-Rong,Ogawa, Masanao,Furutsuka, Kenji,Yoshida, Yuichiro,Suzuki, Kazutoshi
, p. 1879 - 1886 (2004)
In this study, we report the synthesis and reactivity of [ 18F]fluoromethyl iodide ([18F]FCH2I) with various nucleophilic substrates and the stabilities of [18F] fluoromethylated compounds. [18F]FCHs
An electrophilic reagent for the synthesis of OCHFMe-containing molecules
Carbonnel, Elodie,Pannecoucke, Xavier,Besset, Tatiana,Jubault, Philippe,Poisson, Thomas
, p. 2491 - 2493 (2018)
Herein the synthesis of a novel and bench stable electrophilic reagent to construct the OCFHMe motif from O-nucleophiles has been described. This sulfonium salt, readily obtained in 5 steps, reacted with various phenols and alcohols. The resulting products, including complex molecules, were obtained in good yields. This reagent was also used for the functionalization of thiol derivatives.
Novel process for synthesizing 2 -fluorocyclopropylamine with high selectivity and asymmetric synthesis
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, (2021/10/13)
A novel highly selective asymmetric synthesis process of 2 -fluorocyclopropylamine (Structural I). The method provided by the invention uses 1 - fluorine -1 - benzene (propylene) sulfonyl methane and chiral epichlorohydrin to construct chiral cyclopropane under basic conditions, and a new synthetic route not only achieves a special cis-trans selectivity, but also has a highly specific stereoselectivity. The synthesis route is efficient, the reaction condition is mild, the method is suitable for large industrial production in a green environment, 2 -fluorocyclopropylamine production cost is greatly reduced.
Optimized Monofluoromethylsulfonium Reagents for Fluoromethylene-Transfer Chemistry
Sperga, Arturs,Melngaile, Renate,Kazia, Armands,Belyakov, Sergey,Veliks, Janis
, p. 3196 - 3212 (2021/02/27)
An investigation of the properties and reactivity of fluoromethylsulfonium salts resulted in the redesign of the reagents for fluoromethylene transfer chemistry. The model reaction, fluorocyclopropanation of nitrostyrene, turned out to be a suitable platf
COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS
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Paragraph 000353, (2020/12/29)
Disclosed herein are compounds of Formula (I) which inhibit, regulate and/or modulate tyrosine kinase receptors, particularly Axl and Mer signal transduction pathways related to the changes in cellular activities, compositions containing the compounds, methods of using the compounds to treat kinase-dependent diseases and conditions, and methods for making the compounds.
AZETIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
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Paragraph 0225; 0226, (2018/08/29)
The present invention relates to an azetidine derivative for use as a Janus kinase (JAK) inhibitor, a drug composition comprising same, a preparation method therefor, and a use thereof in the treatment of JAK-related diseases comprising, for example, infl
Monofluoromethyl-Substituted Sulfonium Ylides: Electrophilic Monofluoromethylating Reagents with Broad Substrate Scopes
Liu, Yafei,Lu, Long,Shen, Qilong
supporting information, p. 9930 - 9934 (2017/08/08)
Two electrophilic monofluoromethylating reagents, monofluoromethyl(phenyl)sulfonium bis(carbomethoxy)methylide (3 a) and monofluoromethyl(4-nitrophenyl)sulfonium bis(carbomethoxy)methylide (3 b), and their reactions under mild conditions with a variety of nucleophiles, such as alcohols and malonate derivatives, sulfonic and carboxylic acids, phenols, amides, and N heteroarenes, are described. Mechanistic studies with deuterated reagents [D2]3 a/[D2]3 b suggest that these monofluoromethylation reactions proceed through an electrophilic substitution pathway.
Electrochemical Properties and Reactions of Sulfur-Containing Organoboron Compounds
Tanigawa, Masahiro,Kuriyama, Yu,Inagi, Shinsuke,Fuchigami, Toshio
, p. 314 - 318 (2016/04/26)
Electrochemical analyses of 4,4,5,5-tetramethyl-2-phenylsulfanylmethyl-[1,3,2]dioxaborolane and tetra-n-butylammonium phenylthiomethyltrifluoroborate were comparatively studied by cyclic voltammetry measurements and we found for the first time the β-effect of organoborate, which was indicated by experimental and theoretical aspects. The organoborate was found to have a much lower oxidation potential compared to the organoborane. Anodic substitution reaction of organoboronate ester and organoborate was successfully carried out in the presence of nucleophiles to afford the selectively substituted products in good yields.
