60839-94-3Relevant articles and documents
Fluoromethylated derivatives of carnitine biosynthesis intermediates- synthesis and applications
Rydzik, Anna M.,Leung, Ivanhoe K. H.,Thalhammer, Armin,Kochan, Grazyna T.,Claridge, Timothy D. W.,Schofield, Christopher J.
, p. 1175 - 1177 (2014)
A convenient method for the synthesis of fluoromethylated carnitine biosynthesis intermediates, i.e. fluorinated derivatives of γ- butyrobetaine and trimethyllysine, is described. The fluoromethylated probes were useful in both in vitro and cell based ass
[18F]Fluoromethyl iodide ([18F]FCH2I): Preparation and reactions with phenol, thiophenol, amide and amine functional groups
Zhang, Ming-Rong,Ogawa, Masanao,Furutsuka, Kenji,Yoshida, Yuichiro,Suzuki, Kazutoshi
, p. 1879 - 1886 (2004)
In this study, we report the synthesis and reactivity of [ 18F]fluoromethyl iodide ([18F]FCH2I) with various nucleophilic substrates and the stabilities of [18F] fluoromethylated compounds. [18F]FCHs
Novel process for synthesizing 2 -fluorocyclopropylamine with high selectivity and asymmetric synthesis
-
, (2021/10/13)
A novel highly selective asymmetric synthesis process of 2 -fluorocyclopropylamine (Structural I). The method provided by the invention uses 1 - fluorine -1 - benzene (propylene) sulfonyl methane and chiral epichlorohydrin to construct chiral cyclopropane under basic conditions, and a new synthetic route not only achieves a special cis-trans selectivity, but also has a highly specific stereoselectivity. The synthesis route is efficient, the reaction condition is mild, the method is suitable for large industrial production in a green environment, 2 -fluorocyclopropylamine production cost is greatly reduced.
COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS
-
Paragraph 000353, (2020/12/29)
Disclosed herein are compounds of Formula (I) which inhibit, regulate and/or modulate tyrosine kinase receptors, particularly Axl and Mer signal transduction pathways related to the changes in cellular activities, compositions containing the compounds, methods of using the compounds to treat kinase-dependent diseases and conditions, and methods for making the compounds.