611-38-1Relevant academic research and scientific papers
Gem-Dinitroalkyl Benzenes: A Novel Class of IOP-Lowering Agents for the Treatment of Ocular Hypertension
Blangetti, Marco,Rolando, Barbara,Marini, Elisabetta,Chegaev, Konstantin,Guglielmo, Stefano,Lazzarato, Loretta,Lucarini, Laura,Masini, Emanuela,Fruttero, Roberta
supporting information, p. 1054 - 1059 (2017/10/18)
Primary open angle glaucoma is the second most common cause of blindness worldwide. Nitric oxide has recently received particular attention as a potential antiglaucoma agent. In this work, gem-dinitroalkyl benzenes are evaluated for their capability to ac
Bicentral oxidation of nitrosolic acids: Synthesis of 1,1-dinitroalkanes
Sheremetev, Aleksei B.,Aleksandrova, Natal'Ya S.,Suponitsky, Kyrill Yu.
scheme or table, p. 215 - 217 (2011/03/19)
gem-Dinitrozo compounds are cleanly oxidized into the gem-dinitro analogues on treatment with formic acid/hydrogen peroxide system.
Synthesis and Properties of Dinitromethylated Arenes. Reinvestigation of the Ponzio Reaction
Suzuku, Hitomi,Takaoka, Hiroshi,Yamamoto, Hidetoshi,Ogawa, Takuji
, p. 2927 - 2932 (2007/10/02)
Several title compounds have been prepared by the modified Ponzio procedure and their IR, 1 H and 13 C NMR data are presented.In some cases trinitromethylated arenes were obtained as a by-product.Oxidative cleavage to parent aldehydes and oxidation to carboxylic acids were the major competing reactions. 9-Anthracenecarbaldehyde oxime and 10-methyl-9-anthracenecarbaldehyde oxime reacted with nitrogen dioxide in an unexpected way, giving 10-nitro-9-anthracenecarbonitrile oxide and 10-methyl-10-nitro-9-anthrone as the respective main products.Nitration of (dinitromethyl)benzene has also been examined under various conditions.
REACTION OF DINITROMETHYL COMPOUNDS WITH XENON DIFLUORIDE IN VARIOUS SOLVENTS
Tselinskii, I. V.,Mel'nikov, A. A.,Trubitsin, A. E.
, p. 1485 - 1487 (2007/10/02)
The products from the reaction of xenon difluoride with the potassium salts of a series of dinitromethyl compounds ( dinitromethane, trinitromethane, 1,1-dinitroethane, phenyldinitromethane) in methylene chloride, carbon tetrachloride, and acetonitrile were investigated.On the basis of the data from analysis by GLC and UV spectroscopy it was found that in most cases the reaction takes place with the participation of solvent molecules.The proposed reaction mechanism includes a stage of one-electron oxidation of the anion of the dinitromethyl compound by the XeF2 molecule to a dinitromethyl radical.
UNSYMMETRICAL CONNECTIVE OLEFINATION BY KORNBLUM NITRO-SYNTHESIS : APPLICATIONS IN PHYTUBERIN CHEMISTRY
Crombie, Leslie,Roughley, Brian S.
, p. 3147 - 3156 (2007/10/02)
Kornblum unsymmetrical olefin synthesis employing radical-anion chain crossed-coupling (light catalysed) of a mono- and a gem-di-nitro-compound, followed by reductive NO2 removal, is examined in the context of a hindered olefin structure required for phytuberin synthesis.Whilst successful for a tetrasubstituted olefin model (for which a Witting approach failed), increasing substitution on the β-position of the mono-nitro component supressed the coupling reaction, presumably for steric reasons.An alternative coupling involving a bromonitrocyclohexane and a mononitroacetal caused symmetrical coupling of the mononitro-component in high yield, rather than a crossed reaction.Reductive elimination (using Na2S/DMF) from either rac.- or meso- 1,2-dinitro-1,2-diphenylethane leads to (E)-stilbene 98percent (E) > probably through a stabilised radical or anion.A convenient preparation of triphenylisoxazoline-N-oxide is reported.
