62143-69-5

Basic information

• Product Name: 2-(2-phenylbenzooxazol-6-yl)acetic acid
• Synonyms: 2-(2-phenylbenzooxazol-6-yl)acetic acid;2-Phenyl-6-benzoxazoleacetic acid
• CAS NO: 62143-69-5
• Molecular Formula: C₁₅H₁₁NO₃
• Molecular Weight: 253.2527
• Mol File: 62143-69-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 427.5°Cat760mmHg
• Flash Point: 212.4°C
• Appearance: /
• Density: 1.316g/cm³
• Vapor Pressure: 4.53E-08mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: 2-(2-phenylbenzooxazol-6-yl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-phenylbenzooxazol-6-yl)acetic acid(62143-69-5)
• EPA Substance Registry System: 2-(2-phenylbenzooxazol-6-yl)acetic acid(62143-69-5)

Safety Data

• Hazardous Substances Data: 62143-69-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H11NO3/c17-14(18)9-10-6-7-12-13(8-10)19-15(16-12)11-4-2-1-3-5-11/h1-8H,9H2,(H,17,18)

Upstream product

• 62143-68-4 (2-phenyl-benzooxazol-6-yl)-acetonitrile 
• 353525-11-8 methyl (4-amino-3-hydroxyphenyl)acetate 
• 65-85-0 benzoic acid 
• 3743-11-1 N-(2-hydroxy-4-methylphenyl)benzamide 
• 51234-51-6 6-bromomethyl-2-phenyl-benzooxazole 
• 98-88-4 benzoyl chloride 
• 2835-98-5 2-Hydroxy-4-methylanilin 
• 93-89-0 benzoic acid ethyl ester 
• 14016-00-3 6-methyl-2-phenylbenzoxazole 

Downstream Products

• 51234-52-7 (2-phenyl-benzooxazol-6-yl)-acetic acid ethyl ester 
• 1361330-52-0 trans-4-[1-[(2-phenyl-6-benzoxazolyl)acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid 
• 62143-73-1 2-(2-phenyl-benzooxazol-6-yl)-propylamine 
• 51234-54-9 2-(2-phenyl-benzooxazol-6-yl)-propan-1-ol 
• 51234-94-7 2-(2-phenyl-benzooxazol-6-yl)-ethanol 
• 51234-53-8 2-(2-phenyl-benzooxazol-6-yl)-propionic acid ethyl ester 
• 51234-55-0 2-(2-phenyl-benzooxazol-6-yl)-propionamide 
• 62143-72-0 2-(2-phenyl-benzooxazol-6-yl)-propionitrile 
• 51234-58-3 2-(2-phenyl-benzooxazol-6-yl)-propionic acid 

Relevant articles and documents

Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6- benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist

For the purpose of obtaining orally potent VLA-4 inhibitors, we have carried out structural modification of the (N′-phenylureido)phenyl group in compound 1, where the group was found to be attributed to poor pharmacokinetic profile in our previous research. Through modification, we have identified several compounds with both potent in vitro activity and improved oral exposure. In particular, compound 7e with 7-fluoro-2-(1-methyl-1H-indol-3- yl)-1,3-benzoxazolyl group as a novel replacement of the (N′-phenylureido) phenyl group significantly inhibited eosinophil infiltration into bronchoalveolar lavage fluid at 15 mg/kg in an Ascaris-antigen-induced murine bronchial inflammatory model, and its efficacy was comparable to that of the anti-mouse α4 antibody (R1-2).