62281-72-5

Basic information

• Product Name: Benzeneacetic acid, a-hydroxy-2-methyl-, ethyl ester
• CAS NO: 62281-72-5
• Molecular Formula: C11H14O3
• Molecular Weight: 194.23
• Mol File: 62281-72-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, a-hydroxy-2-methyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, a-hydroxy-2-methyl-, ethyl ester(62281-72-5)
• EPA Substance Registry System: Benzeneacetic acid, a-hydroxy-2-methyl-, ethyl ester(62281-72-5)

Safety Data

• Hazardous Substances Data: 62281-72-5(Hazardous Substances Data)

Upstream product

• 924-44-7 glyoxylic acid ethyl ester 
• 108-88-3 toluene 
• 64-17-5 ethanol 
• 85589-35-1 o-methylmandelic acid 
• 933-88-0 ortho-toluoyl chloride 
• 5955-73-7 2-methylbenzoyl cyanide 
• 66644-67-5 ethyl 2-methylbenzoylformate 
• 925-90-6 ethylmagnesium bromide 
• 82128-96-9 2-trimethylsilyloxy-2-(2-methylphenyl)acetonitrile 
• 932-31-0 ortho-tolylmagnesium bromide 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 66644-67-5 ethyl 2-methylbenzoylformate 
• 128839-58-7 ethyl 2-fluoro-2-(2-methylphenyl)acetate 
• 37051-41-5 (+/-)-2-bromo-2-o-tolylacetic acid ethyl ester 
• 32957-07-6 2-amino-5-o-tolyl-oxazol-4-one 
• 62281-64-5 o-Tolyl-triethylsilanyloxy-acetic acid ethyl ester 
• 85589-35-1 o-methylmandelic acid 
• 151954-58-4 3-<<4--3-methylphenyl>methyl>-5,7-dimethyl-2-ethyl-3H-imidazo<4,5-b>pyridine 
• 151954-47-1 3-<<4--3-methylphenyl>methyl>-5,7-dimethyl-2-ethyl-3H-imidazo<4,5-b>pyridine 

Relevant articles and documents

Boron-Catalyzed O-H Bond Insertion of α-Aryl α-Diazoesters in Water

A catalytic, metal-free O-H bond insertion of α-diazoesters in water in the presence of B(C6F5)3·nH2O (2 mol %) was developed, affording a series of α-hydroxyesters in good to excellent yields. The reaction features easy operation and wide substrate scope, and importantly, no metal is needed as compared with the conventional methods. Significantly, this approach further expands the applications of B(C6F5)3 under water-tolerant conditions.

CeCl3·7H2O: An effective additive in ru-catalyzed enantioselective hydrogenation of aromatic α-ketoesters

(Chemical Equation Presented) In the presence of catalytic amounts of CeCl3·7H2O, [RuCl(benzene)(S)-SunPhos]Cl is a highly effective catalyst for the asymmetric hydrogenation of aromatic α-ketoesters. A variety of ethyl α-hydroxy-α-arylacetates have been prepared in up to 98.3% ee with a TON up to 10 000. Challenging aromatic α-ketoesters with ortho substituents are also hydrogenated with high enantioselectivities. The addition of CeCl3·7H2O not only improves the enantioselectivity but also enhances the stability of the catalyst. The ratio of CeCl3·7H2O to [RuCl(benzene)(S)-SunPhos]Cl plays an important role in the hydrogenation reaction with a large substrate/catalyst ratio.

Development of bifunctional salen catalysts: Rapid, chemoselective alkylations of α-ketoesters

Lewis acid-Lewis base salen complexes have been identified as highly efficient catalysts for the addition of dialkylzincs to α-ketoesters. In contrast to aldehydes or ketones, the reaction between diethylzinc and α-ketoesters is significant in the absence of catalyst. In the presence of catalyst, the reaction rate is increased over 100-fold relative to the background. Furthermore, the reduction product, which is a major coproduct with other catalysts, is not observed with these bifunctional salens. As a result, high yields of the addition products can be obtained (57-99%). Both the Lewis acid and Lewis base portions of the catalyst are critical to the reactivity and selectivity. The two separate portions of the catalyst have been shown to function in a cooperative manner. Copyright