6252-10-4

Basic information

• Product Name: lactanilide
• Synonyms: lactanilide;2-HYDROXY-N-PHENYLPROPIONAMIDE
• CAS NO: 6252-10-4
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.18914
• Mol File: 6252-10-4.mol
• Article Data: 17

Chemical Properties

• Melting Point: 57-58 °C
• Boiling Point: 367.7°Cat760mmHg
• Flash Point: 176.2°C
• Appearance: /
• Density: 1.206g/cm³
• Vapor Pressure: 4.7E-06mmHg at 25°C
• Refractive Index: 1.597
• PKA: 13.48±0.20(Predicted)
• CAS DataBase Reference: lactanilide(CAS DataBase Reference)
• NIST Chemistry Reference: lactanilide(6252-10-4)
• EPA Substance Registry System: lactanilide(6252-10-4)

Safety Data

• Hazardous Substances Data: 6252-10-4(Hazardous Substances Data)

Usage

General Description

Lactanilide, also known as 2-hydroxypropyl-2, 4-pyrimidinedione, is a chemical compound used as a topical analgesic and antipruritic medication. It belongs to the group of local anesthetics and works by blocking pain and itching sensations in the skin when applied. Lactanilide is commonly found in over-the-counter creams and lotions used to relieve minor skin irritations, burns, insect bites, and sunburns. It is considered safe and effective for short-term use, but should be used with caution in individuals with sensitive skin or allergies to similar substances. Overall, lactanilide is a useful chemical for providing temporary relief from mild skin discomfort.

InChI:InChI=1/C9H11NO2/c1-7(11)9(12)10-8-5-3-2-4-6-8/h2-7,11H,1H3,(H,10,12)

Upstream product

• 40781-39-3 (S)-(-)-2-bromo-N-phenylpropanamide 
• 849585-22-4 LACTIC ACID 
• 222851-56-1 N-phenylsulfinylamine 
• 591-50-4 iodobenzene 
• 110-70-3 N,N`-dimethylethylenediamine 
• 110-89-4 piperidine 
• 598-81-2 (+/-)-lactamide 
• 62-53-3 aniline 
• 106-49-0 p-toluidine 
• 46114-86-7 pyruvanilide 
• 73622-98-7 (-)-2-phenylcarbamoyloxy-propionic acid 
• 7732-18-5 water 
• 6288-14-8 2-(acetyloxy)-N-phenylpropanamide 
• 42308-20-3 2-bromopropionanilide 

Downstream Products

• 5455-63-0 2-lauroyloxy-propionic acid anilide 
• 46114-86-7 pyruvanilide 
• 1508320-16-8 C₂₇H₂₅NO₂Si 
• 125473-43-0 (S)-N-phenyl-2-hydroxypropionamide 
• 1132759-12-6 2-(4-methoxyphenylamino)-N-phenylpropanamide 
• 1132697-63-2 2-(cyclohexylamino)-N-phenylpropanamide 
• 101961-58-4 2-amino-N-phenylpropanamide 
• 1352723-01-3 2-(octylamino)-N-phenylpropanamide 
• 130594-37-5 2-hydroxyimino-propionic acid anilide 
• 100116-10-7 2-ethoxycarbonyloxy-propionic acid-(4-bromo-anilide) 
• 858273-56-0 2,4-dihydroxy-4-methyl-5-oxo-1-phenyl-pyrrolidine-2-carboxylic acid anilide 
• 1012-87-9 5-methyl-3-phenyl-1,3-oxazolidine-2,4-dione 
• 1003855-72-8 (S)-2-(toluene-sulfonyl-⁽⁴⁾-oxy)-propionic acid anilide 
• 21262-52-2 2-chloro-N-phenylpropanamide 

Relevant articles and documents

Method for preparing alpha-hydroxyamide by reducing alpha-keto amides

The invention relates to a method for preparing alpha-hydroxyamide. Alpha-keto amides and inorganic alkali react in an organic solvent for 6-18 hours at 110-150 DEG C, and the alpha-hydroxyamide is obtained through reduction. According to the preparation

Synthesis of α-hydroxyl amides via direct amidation of lactic acid at solvent- and catalyst-free conditions

The efficient synthesis of α-hydroxy-amides has been achieved by the direct amidation of lactic acid using primary amines. The reactions proceed smoothly under solvent-free conditions without using any catalyst. In general, good to excellent yields of products are obtained.

Fe3+-exchanged clay catalyzed transamidation of amides with amines under solvent-free condition

Fe3+-exchanged montmorillonite is shown to be an effective and reusable heterogeneous catalyst for the transamidation of various amides and amines under solvent-free condition. The catalyst shows high yields and wide substrate scope.