94165-04-5

Upstream product

• 64-17-5 ethanol 
• 17207-57-7 N-benzoyl-3-amino-3-phenylpropionic acid 
• 6335-76-8 3-amino-3-phenylpropionic acid ethyl ester 
• 98-88-4 benzoyl chloride 
• 153524-49-3 1-benzamido-3-ethoxy-3-oxo-1-phenylprop-1-en-2-yl ethyl oxalate 
• 55-21-0 benzamide 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 36816-75-8 ethyl 3-benzamido-3-phenylacrylate 
• 120-46-7 1,3-diphenylpropanedione 
• 10374-29-5 N-benzylidenebenzamide 
• 117067-48-8 1-benzotriazolyl-N-benzoyl-1-phenylmethylamine 
• 105-36-2 ethyl bromoacetate 
• 94104-34-4 3-((E)-3-Oxo-1,3-diphenyl-propenylamino)-3-phenyl-propionic acid ethyl ester 
• 33831-72-0 ethyl 3-amino-3-phenylprop-2-enoate 

Downstream Products

• 1072916-80-3 (S)-3-benzoylamino-3-phenylpropanol 
• 82769-76-4 (S)-3-amino-3-phenylpropanol 
• 27129-49-3 (R)-4-phenyl-imidazolidin-2-one 
• 62779-69-5 (R)-1,2-Diamino-1-phenylethane 
• 101350-70-3 N-((R)-2-isocyanato-1-phenyl-ethyl)-benzamide 
• 40639-03-0 (+/-)-3-benzoylamino-3-phenyl-propionic acid amide 
• 40639-03-0 (S)-3-benzoylamino-3-phenyl-propionic acid amide 

Relevant academic research and scientific papers

Preparation method of 3-aminopropanol or 3-aminopropionic acid derivative

The invention provides a preparation method of an optically active 3-aminopropanol or 3-aminopropionic acid derivative, and belongs to the technical field of organic synthesis. A compound having a structure as shown in a formula II and a formula III is used as a raw material, and the optically active 3-aminopropanol or 3-aminopropionic acid derivative is obtained through four basic steps, namely dehydration condensation, hydrogenation reduction, reduction and hydrolysis. The raw materials adopted in the preparation method are easy to obtain and low in cost; as a chiral phosphine-transitional metal catalyst is used in the hydrogenation reduction reaction, the optically active 3-aminopropanol or 3-aminopropionic acid derivative is efficient, high in selectivity, low in cost and suitable forlarge-scale production. Compared with existing chemical resolution and chiral introduction, the asymmetric hydrogenation synthesis method provided by the invention only produces one chiral product, ishigh in yield, and has relatively high advantages in economy and raw material utilization rate.

Chemo- and biocatalytic strategies to obtain phenylisoserine, a lateral chain of Taxol by asymmetric reduction

Enriched ethyl 3-benzamido-2-hydroxy-3-phenylpropanoate (protected phenylisoserine), the chiral side chain of Taxol, was obtained via asymmetric reduction with transition metal-diphoshine complexes or with whole cells of non-conventional yeasts. Asymmetri

A mild method for protodesilylation of α-dimethylphenylsilyl ester substrates

Mild conditions (1.2 eq. Hg(OAc)2, 1.2 eq. TBAF in 1:1 MeOH/THF; 35 min at 0 °C) have been developed for the protodesilylation of α- dimethylphenylsilyl esters. An enolate-dependent mechanism for the reaction was supported through studies indicating the clean incorporation of deuterium. To further investigate the mechanism, the optimal conditions as well as the kinetics of the reaction were explored.

The preparation of functionalized amines and amides using benzotriazole derivatives and organozinc reagents

Secondary and tertiary amines 6 are conveniently prepared in good yields by reacting organozinc halides with adducts 4, which are derived from the corresponding amines, aldehydes and benzotriazole. The use of organozinc reagents enables the introduction of nitro, cyano or ester functionalities into amine mainframes. This methodology was also used to prepare functionalized amides 8.