628-94-4 Usage
Description
Adipamide is a chunky white powder. It is slightly soluble in water and incompatible
with strong oxidising agents. Adipamide on combustion and decomposition produces
hazardous products of toxic fumes of carbon monoxide, carbon dioxide, and nitrogen
oxides. Exposures to adipamide by inhalation, ingestion, or skin absorption cause adverse
health. The symptoms include irritation of the eyes, skin, mucous membranes, and upper
respiratory tract. There is no complete information about the toxicological properties of
the chemical.
Chemical Properties
Different sources of media describe the Chemical Properties of 628-94-4 differently. You can refer to the following data:
1. Adipamide is white powder and chunks. It is slightly soluble in water and incompatible
with strong oxidizing agents. On combustion and decomposition, adipamide produces
toxic fumes of carbon monoxide, carbon dioxide, and nitrogen oxides.
2. Adipamide is powder in appearance and slightly soluble in water. It is incompatible with
strong oxidizing agents. On combustion or decomposition, adipamide releases hazardous
products, toxic fumes of carbon monoxide, carbon dioxide, and nitrogen oxides.
Uses
Adipamide has been used in the preparation of bisimidates.
Air & Water Reactions
Slightly soluble in water .
Reactivity Profile
ADIPAMIDE forms flammable gases with strong reducing agents. A very weak base. Mixing with dehydrating agents such as P2O5 or SOCl2 generates adiponitrile. Combustion generates toxic mixed oxides of nitrogen (NOx).
Health Hazard
Different sources of media describe the Health Hazard of 628-94-4 differently. You can refer to the following data:
1. Exposures to adipamide by inhalation, ingestion, or skin absorption cause adverse health
effects. The symptoms include irritation of the eyes, skin, mucous membranes, and upper
respiratory tract. There is no complete information about the toxicological properties of
the chemical.
2. Exposures to adipamide cause health disorders such as irritation to the skin, eyes, and
respiratory system. No specifi c adverse health effects have been reported from human
exposure to polyhexamethylene adipamide, except for mechanical irritation of the skin
and eyes caused by particles. Signifi cant skin permeation and systemic toxicity after contact
appears unlikely. The compound is not likely to be hazardous by skin contact, but
cleansing the skin after use is advisable. If molten polymer gets on the skin, cool rapidly with cold water. Workers should not attempt to peel polymer from skin, but consult a
medical unit for treatment of thermal burn.
Fire Hazard
The flash point of ADIPAMIDE has not been determined, but ADIPAMIDE is probably combustible.
Safety Profile
Moderately toxic by ingestion. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits toxic fumes of NOx,.
storage
Different sources of media describe the storage of 628-94-4 differently. You can refer to the following data:
1. Adipamide should be kept stored in a cool, dry place, with containers tightly closed to
prevent moisture absorption and contamination.
2. Workers should avoid repeated exposures to adipamide. During use, workers should wear
suitable protective clothing, self-contained breathing apparatus, chemical safety goggles,
rubber boots, and heavy rubber gloves.
Precautions
During use and handling of adipamide, workers should wear self-contained breathing
apparatus, rubber boots, heavy rubber gloves, and chemical safety goggles to avoid
splashing of material. A full-face mask respirator provides protection from eye irritation.
Workers should avoid exposure to high concentrations of dust. No specifi c intervention is
indicated as the compound is not likely to be hazardous by inhalation. Consult a physician
if necessary. If exposed to fumes from overheating or combustion, move to fresh air.
Consult a physician if symptoms persist.
Check Digit Verification of cas no
The CAS Registry Mumber 628-94-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 8 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 628-94:
(5*6)+(4*2)+(3*8)+(2*9)+(1*4)=84
84 % 10 = 4
So 628-94-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H11NO3/c7-5(8)3-1-2-4-6(9)10/h1-4H2,(H2,7,8)(H,9,10)
628-94-4Relevant articles and documents
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Erlenmeyer,Bischoff
, p. 412 (1944)
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Synthetic method of adiponitrile
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Page/Page column 0030-0032; 0035-0037; 0039-0041; 0043-0045; 0049, (2020/05/30)
The invention provides a synthetic method of adiponitrile. The target product adiponitrile can be obtained by taking 1, 3-butadiene which is relatively easy to obtain as an initial raw material, carrying out a hydroaminocarbonylation reaction on terminal olefin of 1, 3-butadiene and then dehydrating, and the whole preparation process is mild in condition, good in reaction selectivity, high in yield, clean and non-toxic in reaction raw material and catalyst and small in environmental pollution.
METHOD FOR PRODUCING ADIPAMIDE AS INTERMEDIATE FOR PRODUCTION OF RAW MATERIAL FOR BIO-BASED NYLON
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Paragraph 0064-0084, (2020/03/17)
Disclosed is a method for producing adipamide, which may include the steps of: (a) reacting glucose, nitric acid (HNO3), sodium nitrite (NaNO2) and potassium hydroxide (KOH) to produce a glucaric acidpotassium salt, (b) producing glucamide by reacting the glutaric acid potassium salt, with an acidic solution and removing a potassium ion from the glucaric acid potassium salt, (c) preparing an reaction admixture by adding the glucamide and a catalyst to hydrogen halide and acetic acid, and (d) treating the reaction admixture with hydrogen gas in a reactor thereby producing the adipamide.
Transfer Hydration of Dinitriles to Dicarboxamides
Naka, Hiroshi,Naraoka, Asuka
supporting information, p. 1977 - 1980 (2019/10/22)
We present a robust method for double transfer hydration of dinitriles to afford diamides. The transfer hydration of 1, n -dinitriles (n = 1-6) proceeds smoothly in the presence of a palladium(II) catalyst with acetamide as a water donor, affording the corresponding diamides in moderate to high yields, without involving significant side reactions such as monohydration or cyclization. The equilibrium was shifted in the forward direction by removing coproduced acetonitrile under reduced pressure.
