6282-00-4

Usage

Uses

Used in Chemical Synthesis:
N,N-Di-N-propylformamide is used as a reagent in the chemical synthesis of various organic compounds. Its unique structure allows it to participate in a range of reactions, such as condensation, substitution, and rearrangement reactions, making it a versatile building block for the synthesis of complex molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N,N-di-N-propylformamide is used as an intermediate in the synthesis of various drugs and drug candidates. Its ability to form stable complexes with other molecules makes it a promising candidate for the development of new therapeutic agents.
Used in Material Science:
N,N-Di-N-propylformamide can be used in the development of novel materials with specific properties. For example, it can be incorporated into polymers to modify their physical and chemical properties, such as solubility, stability, and reactivity.
Used in Solvent Applications:
Due to its polar nature, N,N-di-N-propylformamide can be used as a solvent in various chemical processes. It can dissolve a wide range of compounds, making it suitable for use in reactions that require a polar, aprotic solvent.
Used in Analytical Chemistry:
N,N-Di-N-propylformamide can be employed as a mobile phase in chromatographic techniques, such as high-performance liquid chromatography (HPLC) and gas chromatography (GC). Its unique properties allow for the separation and analysis of various compounds, making it a valuable tool in analytical chemistry.

InChI:InChI=1/C7H15NO/c1-3-5-8(7-9)6-4-2/h7H,3-6H2,1-2H3

Upstream product

• 70785-80-7 dipropyl-oxalamic acid 
• 201230-82-2 carbon monoxide 
• 142-84-7 di-n-propylamine 
• 184110-00-7 ethyl 2-(dipropylamino)-2-oxoacetate 
• 50-00-0 formaldehyd 
• 122-51-0 orthoformic acid triethyl ester 
• 113388-44-6 (formyloxy)(acetoxy)phenylmethane 
• 102-69-2 tri-n-propylamine 
• 96-26-4 dihydroxyacetone 
• 109-94-4 formic acid ethyl ester 
• 66772-82-5 N,N-di-n-propyl-1-imidazolecarboxamide 
• 68-12-2 N,N-dimethyl-formamide 
• 124-38-9 carbon dioxide 
• 141-53-7 sodium formate 

Downstream Products

• 1238675-78-9 N,N-dipropyl-(diphenylphosphinomethylene)iminium iodide 
• 17364-40-8 4,5-dihydro-1,3-diphenyl-5-oxo-1H-pyrazole-4-carboxaldehyde 
• 3405-42-3 N-methyldipropylamine 
• 14657-86-4 N,N-dipropylbenzamide 
• 54408-44-5 S-Phenyl N,N-dipropylthiocarbamate 

Relevant academic research and scientific papers

Mesoporous Sn(IV) Doping DFNS Supported BaMnO3 Nanoparticles for Formylation of Amines Using Carbon Dioxide

Abstract: In the present paper, Sn(IV) doping DFNS (SnD) supported nanoparticles of BaMnO3 (BaMnO3/SnD) and using as a catalyst for the N-formylation of amines by CO2 hydrogenation. In this catalyst, the SnD with the ratios of Si/Sn in the range of from 6 to 50 were obtained with method of direct hydrothermal synthesis (DHS) as well as the nanoparticles of BaMnO3 were on the surfaces of SnD in situ reduced. Scanning electron microscope (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), X-ray energy dispersive spectroscopy (EDS), and transmission electron microscopy (TEM) were utilized for characterizing the nanostructures BaMnO3/SnD. It is found that the nanostructures of BaMnO3/SnD can be a nominate due to its effective and novel catalytic behavior in N-formylation of amines through hydrogenation of CO2. Graphic Abstract: [Figure not available: see fulltext.]

The synthesis of cyanoformamides via a CsF-promoted decyanation/oxidation cascade of 2-dialkylamino-malononitriles

A mild and efficient method for the synthesis of cyanoformamides from N,N-disubstituted aminomalononitriles with CsF as the promoter has been developed. This method features a wide substrate scope and high reaction efficiency, and will facilitate corresponding cyanoformamide-based biological studies and synthetic methodology development.

Practical Catalytic Cleavage of C(sp3)?C(sp3) Bonds in Amines

The selective cleavage of thermodynamically stable C(sp3)?C(sp3) single bonds is rare compared to their ubiquitous formation. Herein, we describe a general methodology for such transformations using homogeneous copper-based catalysts in the presence of air. The utility of this novel methodology is demonstrated for Cα?Cβ bond scission in >70 amines with excellent functional group tolerance. This transformation establishes tertiary amines as a general synthon for amides and provides valuable possibilities for their scalable functionalization in, for example, natural products and bioactive molecules.

Choline-based ionic liquids for CO2 capture and conversion

Choline-based ionic liquids (Ch-ILs) with anions possessing interacting sites to attract CO2 were designed, which could capture CO2 with capacity >1.0 mol CO2 per molar IL under ambient conditions. Moreover, this kind of ILs combining with CuCl could catalyze the formylation of amines with CO2/H2 at 120 °C. Especially, choline imidazolate showed the best performance, affording a series of N-formamides in excellent yields. It was demonstrated that the IL activated CO2 and the synergistic effect between the IL and CuCl resulted in the high activity for catalysing the formylation of amines with CO2/H2.

Ethanol-mediated N-formylation of amines with CO2/H2 over cobalt catalysts

The CO2-involved synthesis of chemicals is of great significance from a green and sustainable point of view. Herein, we present an efficient Co-based catalytic system composed of a commercially available Co salt, the tetradentate phosphine ligand P-(CH2CH2PPh2)3, and a base, denoted as [Co]/PP3/base, for the synthesis of formamides via the formylation of amines with CO2/H2. It was indicated that the selectivity of products (i.e., formamide or methylamine) could be tuned to some extent via changing the solvent and the base. Using ethanol as the solvent, the Co(ClO4)2·6H2O/PP3/K2CO3 system showed high activity for the production of formamides, affording product yields of 82-95%, together with its broad substrate scope. Exploration of the reaction mechanism indicated that formamide was formed with HCOOH as the intermediate, while the methylamine byproduct was produced with HCHO as the intermediate via the hydrogenolysis of dialkylaminomethane.

N-doped carbon supported Pd catalysts for N-formylation of amines with CO2/H2

Using mesoporous N-doped carbons (NCs) derived from glucose and melamine as the supports, a series of Pd/NC catalysts were prepared, in which Pd nanoparticles with average size2 and H2 in ethanol without any additives. Especially, the catalyst Pd/NC-800-6.9% containing quaternary N showed the best performance, affording a series of formylamides in good or even excellent yields. Further investigation reveals that the interaction between the Pd nanoparticles and quaternary nitrogen in the NC support was responsible for the good performance of the catalyst.

Synthesis of New Class of Copper(II) Complex-Based FeNi3/KCC-1 for the N-Formylation of Amines Using Dihydrogen and Carbon Dioxide

This study investigated the potential application of an efficient, easily recoverable, and reusable copper(II)-based catalyst bearing polyvinyl alcohol (PVA) immobilized on FeNi3/KCC-1/APTPOSS [FeNi3/KCC-1/APTPOSS/TCT/PVA/Cu(II)] magnetic nano-particles (MNPs) for the N-formylation of amines via CO2 hydrogenation. FeNi3/KCC-1/TCT/PVA/Cu(II) MNPs were thoroughly characterized by transmission electron microscopy, field emission-scanning electron microscopy, vibrating sample magnetometry, thermo-gravimetric analysis, inductively coupled plasma-mass spectrometry (ICP-MS), and the Brunauer, Emmett, and Teller method. After the reaction, only minor changes to the morphology of the catalyst recycled by the ICP-MS were evidenced, thus corroborating its robustness. Graphical Abstract: [Figure not available: see fulltext.]

Mesoporous imine-based organic polymer: catalyst-free synthesis in water and application in CO2 conversion

A mesoporous imine-functionalized organic polymer (Imine-POP) was prepared based on the reaction of an aryl ammonium salt with an aromatic aldehyde in water without any catalyst and template. The Pd coordinated Imine-POP exhibited high catalytic activity for the N-formylation of amines with CO2/H2 at 100 °C, affording a series of formamides in high yields.

Method for preparing N-formylated amine compounds

The invention discloses a method for preparation N-formylated amine compounds. In the method, the amine compounds and 1,3-dihydroxy acetone are taken as reaction raw materials reacting in a reactor for 2-48 hours at the reaction temperature of 0-100DEG C in a reaction medium in the presence of composite catalysts and oxidants, and the N-formylated amine compounds are obtained. The method is simpleand moderate in reaction conditions, cost can be reduced, target products can be obtained with high yield, and the catalysts used have high catalytic activity and are easy to be separated from a reaction system and reuses; the method is environment friendly during the whole process, the reaction raw materials are easy to be converted from biodiesel by-product propylene glycol, and use of glycerolis facilitated.

A tertiary amine oxidation cracking method of preparing carboxamide

The invention provides a method for preparing formamide through tertiary amine oxicracking. According to the method, tertiary amine serves as a substrate, air or oxygen serves as an oxygen source, and oxicracking occurs on the tertiary amine under the action of a catalyst to generate the formamide. The method is high in oxidation efficiency and product yield and economical and environmentally friendly by taking the air or oxygen as the oxygen source and has a very good application prospect.