63046-14-0

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 6-chloro-2-(4-methoxyphenyl)-
• CAS NO: 63046-14-0
• Molecular Formula: C16H11ClO3
• Molecular Weight: 286.715
• Mol File: 63046-14-0.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 6-chloro-2-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 6-chloro-2-(4-methoxyphenyl)-(63046-14-0)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 6-chloro-2-(4-methoxyphenyl)-(63046-14-0)

Safety Data

• Hazardous Substances Data: 63046-14-0(Hazardous Substances Data)

Upstream product

• 123743-15-7 6-chloro-2-(4-methoxyphenyl)chroman-4-one 
• 1450-74-4 5-chloro-2-hydroxyacetophenone 
• 100-07-2 4-methoxy-benzoyl chloride 
• 1226-09-1 (E)-1-(5-chloro-2-hydroxyphenyl)-3-(4-methoxyphenyl)-prop-2-en-1-one 
• 1376543-59-7 C₁₇H₁₅ClO₄ 
• 123-11-5 4-methoxy-benzaldehyde 
• 126267-42-3 2'-hydroxy-5'-chloro-4-methoxychalcone 
• 201230-82-2 carbon monoxide 
• 71643-66-8 4-chloro-2-iodo phenol 
• 768-60-5 4-methoxyphenylacetylen 
• 1657006-70-6 C₁₉H₁₇Br₂ClO₃ 
• 1657006-90-0 C₁₉H₁₇ClO₃ 
• 27007-53-0 methyl-2-bromo-5-chlorobenzoate 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Relevant articles and documents

Divergent synthesis of flavones and aurones via base-controlled regioselective palladium catalyzed carbonylative cyclization

A regioselective approach for construction of 5-membered and 6-membered flavonoid is established by Pd catalyzed carbonylative cyclization of 2-iodophenol with terminal alkynes using different amine bases under mild reaction condition. The catalytic experiments found that piperazine preferentially accelerate 6-endo cyclization, and triethylamine mediated Pd catalyzed 5-exo cyclization. Under optimized reaction condition, Pd catalyzed carbonylative protocol successfully applied for the diverse structures of 39 examples in good to excellent yield and regioselectivity.

Synthesis and biological activities of some flavones

Chalcones are synthesized by a base catalyzed Claisen Schmidt condensation reaction and then treated with dimethylsulphoxide in presence of iodine to get flavones. The synthesized compounds were evaluated for their antibacterial activity against Escherichia coli, P. aeruginosa, S. epidermidis and B. subtilis. All the flavones showed moderate to good activity. The structures of these compounds were confirmed by IR, UV, 1H NMR, Mass and elemental analysis.

K2CO3-catalyzed synthesis of chromones and 4-quinolones through the cleavage of aromatic C-O bonds

Phenol-derived electrophiles are favorable substrates because phenols are naturally abundant or can be readily prepared from other aromatic compounds. However, the cleavage of aromatic C-O bonds is a great challenge because of their high energy. K2CO3-catalyzed intramolecular cyclization of 1-(2-alkoxyphenyl)-3-akylpropane-1,3-dione and 3-(alkylimino)-1-(2-methoxyphenyl)-2-methylpropan-1-one derivatives via the selective cleavage of aromatic C-O bonds is reported. The corresponding chromone and 4-quinolone derivatives were obtained in reasonable yields.