66374-10-5

Usage

Uses

Used in Pharmaceutical Industry:
2-[(Z)-2-phenylethenyl]benzoic acid is used as a ligand for targeting specific receptors and proteins within the body. Its unique structure allows for the development of drugs that can interact with biological targets, potentially leading to treatments for a range of diseases and conditions.
Used in Organic and Medicinal Chemistry:
2-[(Z)-2-phenylethenyl]benzoic acid is utilized in the synthesis of various organic and medicinal chemistry products. Its chemical properties make it a valuable building block for creating new compounds with potential therapeutic applications, contributing to the advancement of pharmaceutical research and development.
While the provided materials do not specify the exact applications or industries where 2-[(Z)-2-phenylethenyl]benzoic acid is used, the general information suggests that its potential lies in the pharmaceutical sector and in the broader field of organic and medicinal chemistry. Further research and development would be necessary to explore and confirm its specific uses and benefits in these areas.

Upstream product

• 5079-90-3 (E)-2-styrylbenzoic acid 
• 81428-81-1 Methyl (E)-2-(2-phenylethenyl)benzoate 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 95-46-5 2-methylphenyl bromide 
• 7011-98-5 3-benzyl-3H-isobenzofuran-1-one 
• 87717-18-8 Ethyl 2-(2-phenylethenyl)benzoate 
• 6091-64-1 2-bromobenzoic acid ethyl ester 
• 100-42-5 styrene 
• 14783-89-2 ortho-carboxybenzenediazonium tetrafluoroborate 
• 7677-24-9 trimethylsilyl cyanide 
• 62-53-3 aniline 
• 119-67-5 o-carboxybenzaldehyde 
• 4877-77-4 (Z)-1-bromo-2-(2-phenylethenyl)benzene 
• 88-67-5 2-Iodobenzoic acid 

Downstream Products

• 2674-44-4 3-phenyl-isochroman-1-one 
• 4890-85-1 o-phenethylbenzoic acid 
• 106477-49-0 (+/-)-erythro-α,α'-dibromo-bibenzyl-2-carboxylic acid 
• 92496-76-9 erythro (3RS,8SR)-3-isobenzofuran-1(3H)-one 
• 92496-76-9 threo (3RS,8RS)-3-isobenzofuran-1(3H)-one 
• 64283-88-1 (3RS,4RS)-4-hydroxy-3-phenyl-isochroman-1-one 
• 100954-88-9 (+/-)-cis-4-chloro-3-phenyl-isochroman-1-one 
• 5079-90-3 (E)-2-styrylbenzoic acid 
• 66374-11-6 (Z)-3,4-Benzo-1-diazo-6-phenyl-3,5-hexadien-2-on 
• 78317-99-4 (+/-)-cis-4-bromo-3-phenyl-isochroman-1-one 
• 100954-90-3 (RS)-3-((SR)-α-chloro-benzyl)-phthalide 
• 100954-90-3 (RS)-3-((RS)-α-chloro-benzyl)-phthalide 
• 92424-73-2 3-(nitro-phenyl-methylene)-3H-isobenzofuran-1-one 
• 106477-49-0 α,α'-dibromo-bibenzyl-2-carboxylic acid 

Relevant academic research and scientific papers

Synthesis and characterization of mesoporous organosilica supported palladium (SBA-Pr-NCQ-Pd) as an efficient nanocatalyst in the Mizoroki–Heck coupling reaction

In the present study, the modification of a mesoporous organosilica nanocomposite SBA-15 (Santa Barbara Amorphous 15) was carried out in two steps, first through the surface functionalization of SBA-Pr-NH2 with 2-chloroquinoline-3-carbaldehyde to form SBA-Pr-NCQ, and then through a post-modification process with palladium ions. The target nanocompound structure of SBA-Pr-NCQ-Pd was characterized by different techniques (thermogravimetric analysis, X-ray diffraction, scanning electron microscopy, Energy-dispersive X-ray spectroscopy (EDX), and Fourier transform infrared spectroscopy). The catalytic performance of the porous inorganic–organic hybrid nanocomposite (SBA-Pr-NCQ-Pd) in one of the most important carbon–carbon bond-forming processes, the Mizoroki–Heck coupling reaction of aryl halides and methacrylate in water/ethanol media, was examined. Compared to previous reports, this protocol afforded some advantages, such as high yields of products, short reaction times, catalyst stability without leaching, simple methodology, easy workup, and greener conditions. Also, the nanocatalyst can be easily separated from the reaction mixture and reused several times without a significant decrease in activity and promises economic as well as environmental benefits.

COMPOUNDS FOR MODULATING DDAH AND ADMA LEVELS, AS WELL AS METHODS OF USING THEREOF TO TREAT DISEASE

Disclosed are compounds that can modulate DDAH and the amount of asymmetric dimethylarginine (ADMA) in a subject. Also provided are pharmaceutical compositions comprising these compounds, as well as methods of using these compositions to treat and/or prevent diseases associated with elevated or low levels of DDAH and ADMA.

Intramolecular Hydroamidation of ortho-Vinyl Benzamides Promoted by Potassium tert-Butoxide/N,N-Dimethylformamide

An intramolecular hydroamidation of ortho-vinyl benzamides had been developed. The reaction was promoted efficiently by potassium tert-butoxide and N,N-dimethylformamide without the need for strong oxidants or transition-metal catalysts. A series of dihyd

Copper-Catalyzed Amino Lactonization and Amino Oxygenation of Alkenes Using O-Benzoylhydroxylamines

A copper-catalyzed amino lactonization of unsaturated carboxylic acids has been achieved as well as the analogous intermolecular three-component amino oxygenation of olefins. The transformation features mild conditions and a remarkably broad substrate sco

Synthesis of Secondary Unsaturated Lactams via an Aza-Heck Reaction

The preparation of unsaturated secondary lactams via the palladium-catalyzed cyclization of O-phenyl hydroxamates onto a pendent alkene is reported. This method provides rapid access to a broad range of lactams that are widely useful building blocks in alkaloid synthesis. Mechanistic studies support an aza-Heck-type pathway.

A facile and efficient method for the synthesis of N-substituted 3-oxoisoindoline-1-carbonitrile derivatives catalyzed by sulfamic acid

A new and efficient method for the synthesis of N-substituted 3-oxoisoindoline-1-carbonitrile derivatives by a one-pot, three-component condensation reaction of 2-carboxybenzaldehyde, primary amine, and TMSCN in the presence of 10 mol % sulfamic acid (NH2SO3H) as the catalyst in EtOH under reflux temperature is described. The process is simple and environmentally benign and the catalyst is commercially available and inexpensive. ARKAT-USA, Inc.

Expeditious synthesis of 3,4-dihydroisocoumarins and phthalides using the Heck-Matsuda reaction

Several 3,4-dihydroisocoumarins and phthalides were synthesized by an effective Heck-Matsuda reaction involving an ortho carboxybenzenediazonium salt with a series of styrenes bearing electron donating and electron withdrawing groups, methylvinyl ketone,

Benzamidoaldehydes and their use as cysteine protease inhibitors

Compounds of the formula where R1, R2, R3, X and n are as defined in the description, are inhibitors of cysteine protease.

Base-catalyzed ring openings of benzocyclobutenones and -ols

The base-catalyzed ring opening of a number of isomeric E- and Z-benzylidenebenzocyclobutenones and -ols has been studied in both protic and aprotic solvents.Cleavage of the C1-C2 bond results in the formation of stilbenes with mainly, and at times exclusively, retained stereochemistry.For the alcohols, these results point to an oxyanion-induced carbon-carbon bond cleavage leading to a vinyl anion that is protonated with retention of configuration in the protic solvents rather than to an electrocyclic ring opening to an alkoxy o-quinodimethane.Reaction of the Z isomer of benzylidenebenzocyclobutenol with methyllithium in THF at 20 deg C causes isomerization to the E isomer, cleavage of the C1-C2 bond, and recyclization of the resultant isomerized vinyl anion. - Key words: benzylidenebenzocyclobutenones, base-catalyzed ring opening; benzylidenebenzocyclobutenols, base-catalyzed ring opening.

Analysis of the 13C and 1H Spectra of Mixtures of Benzylidene Derivatives

The 1H and 13C NMR spectra of methyl (E)-2,3-diphenylprop-2-enoate and methyl (E)-2-(2-phenylethenyl)benzoate resulting from the electrocyclic ring opening of benzocyclobutenone starting materials have been assigned.A combination of direct detection 2D NMR techniques, COSY, HETCOR, and FLOCK, provided the assignments of the 1H and 13C resonances. - Keywords: NMR 1H NMR 13C NMR Benzylidene derivatives