66374-10-5

Basic information

• Product Name: 2-[(Z)-2-phenylethenyl]benzoic acid
• CAS NO: 66374-10-5
• Molecular Formula: C₁₅H₁₂O₂
• Molecular Weight: 224.2546
• Mol File: 66374-10-5.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 397.2°C at 760 mmHg
• Flash Point: 182.6°C
• Density: 1.211g/cm³
• Vapor Pressure: 5.06E-07mmHg at 25°C
• Refractive Index: 1.687
• CAS DataBase Reference: 2-[(Z)-2-phenylethenyl]benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(Z)-2-phenylethenyl]benzoic acid(66374-10-5)
• EPA Substance Registry System: 2-[(Z)-2-phenylethenyl]benzoic acid(66374-10-5)

Safety Data

• Hazardous Substances Data: 66374-10-5(Hazardous Substances Data)

Usage

General Description

2-[(Z)-2-phenylethenyl]benzoic acid is a chemical compound that consists of a benzene ring with a carboxylic acid functional group and a phenyl group attached to it by a 2-phenylethenyl bond. 2-[(Z)-2-phenylethenyl]benzoic acid has potential applications in pharmaceuticals, as it can act as a ligand for targeting specific receptors and proteins in the body. It also has potential uses in the production of organic and medicinal chemistry products. However, it is important to note that this compound may have certain risks associated with its use, and proper safety precautions and handling should be considered when working with it.

Upstream product

• 60494-73-7 (2-methoxycarbonylbenzyl)triphenylphosphonium bromide 
• 100-52-7 benzaldehyde 
• 15160-49-3 3t-(2-bromo-phenyl)-2-phenyl-acrylic acid 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 88-65-3 2-bromobenzoic-acid 
• 100-42-5 styrene 
• 6091-64-1 2-bromobenzoic acid ethyl ester 
• 88-67-5 2-Iodobenzoic acid 
• 7677-24-9 trimethylsilyl cyanide 
• 62-53-3 aniline 
• 119-67-5 o-carboxybenzaldehyde 
• 14783-89-2 ortho-carboxybenzenediazonium tetrafluoroborate 
• 7011-98-5 3-benzyl-3H-isobenzofuran-1-one 

Downstream Products

• 2674-44-4 3-phenyl-isochroman-1-one 
• 4890-85-1 o-phenethylbenzoic acid 
• 106477-49-0 (+/-)-erythro-α,α'-dibromo-bibenzyl-2-carboxylic acid 
• 92496-76-9 erythro (3RS,8SR)-3-isobenzofuran-1(3H)-one 
• 92496-76-9 threo (3RS,8RS)-3-isobenzofuran-1(3H)-one 
• 64283-88-1 (3RS,4RS)-4-hydroxy-3-phenyl-isochroman-1-one 
• 100954-88-9 (+/-)-cis-4-chloro-3-phenyl-isochroman-1-one 
• 5079-90-3 (E)-2-styrylbenzoic acid 
• 118-90-1 ortho-methylbenzoic acid 
• 65-85-0 benzoic acid 
• 100954-90-3 (RS)-3-((SR)-α-chloro-benzyl)-phthalide 
• 100954-90-3 (RS)-3-((RS)-α-chloro-benzyl)-phthalide 
• 40523-32-8 3-(phenylmethylene)isoindol-1-one 
• 33608-93-4 (E)-2,3-dihydro-3-phenylmethylene-1H-isoindol-1-one 

Relevant articles and documents

Synthesis and characterization of mesoporous organosilica supported palladium (SBA-Pr-NCQ-Pd) as an efficient nanocatalyst in the Mizoroki–Heck coupling reaction

In the present study, the modification of a mesoporous organosilica nanocomposite SBA-15 (Santa Barbara Amorphous 15) was carried out in two steps, first through the surface functionalization of SBA-Pr-NH2 with 2-chloroquinoline-3-carbaldehyde to form SBA-Pr-NCQ, and then through a post-modification process with palladium ions. The target nanocompound structure of SBA-Pr-NCQ-Pd was characterized by different techniques (thermogravimetric analysis, X-ray diffraction, scanning electron microscopy, Energy-dispersive X-ray spectroscopy (EDX), and Fourier transform infrared spectroscopy). The catalytic performance of the porous inorganic–organic hybrid nanocomposite (SBA-Pr-NCQ-Pd) in one of the most important carbon–carbon bond-forming processes, the Mizoroki–Heck coupling reaction of aryl halides and methacrylate in water/ethanol media, was examined. Compared to previous reports, this protocol afforded some advantages, such as high yields of products, short reaction times, catalyst stability without leaching, simple methodology, easy workup, and greener conditions. Also, the nanocatalyst can be easily separated from the reaction mixture and reused several times without a significant decrease in activity and promises economic as well as environmental benefits.

Intramolecular Hydroamidation of ortho-Vinyl Benzamides Promoted by Potassium tert-Butoxide/N,N-Dimethylformamide

An intramolecular hydroamidation of ortho-vinyl benzamides had been developed. The reaction was promoted efficiently by potassium tert-butoxide and N,N-dimethylformamide without the need for strong oxidants or transition-metal catalysts. A series of dihyd

Synthesis of Secondary Unsaturated Lactams via an Aza-Heck Reaction

The preparation of unsaturated secondary lactams via the palladium-catalyzed cyclization of O-phenyl hydroxamates onto a pendent alkene is reported. This method provides rapid access to a broad range of lactams that are widely useful building blocks in alkaloid synthesis. Mechanistic studies support an aza-Heck-type pathway.