6311-65-5

Basic information

• Product Name: NSC43235
• Synonyms: NSC43235;N-(4-Methylphenyl)benzenesulfonamide;N-(p-Tolyl)benzenesulfonamide
• CAS NO: 6311-65-5
• Molecular Formula: C₁₃H₁₃NO₂S
• Molecular Weight: 247.3128
• Mol File: 6311-65-5.mol
• Article Data: 56

Chemical Properties

• Melting Point: 70 °C(Solv: ethanol (64-17-5))
• Boiling Point: 393.7°Cat760mmHg
• Flash Point: 191.9°C
• Appearance: /
• Density: 1.269g/cm³
• Vapor Pressure: 2.09E-06mmHg at 25°C
• Refractive Index: 1.621
• PKA: 8.99±0.10(Predicted)
• CAS DataBase Reference: NSC43235(CAS DataBase Reference)
• NIST Chemistry Reference: NSC43235(6311-65-5)
• EPA Substance Registry System: NSC43235(6311-65-5)

Safety Data

• Hazardous Substances Data: 6311-65-5(Hazardous Substances Data)

Usage

General Description

NSC43235 is a synthetic chemical compound that has been studied for its potential anti-cancer properties. It has been shown to inhibit the growth of tumor cells in various cancer types, including breast, lung, colon, and prostate cancers. NSC43235 is thought to work by targeting specific molecular pathways involved in cell growth and survival. Research suggests that it may have a role in suppressing the proliferation and metastasis of cancer cells, making it a potential candidate for the development of new cancer therapies. Further studies are needed to fully understand its mechanism of action and potential applications in the treatment of cancer.

InChI:InChI=1/C13H13NO2S/c1-11-7-9-12(10-8-11)14-17(15,16)13-5-3-2-4-6-13/h2-10,14H,1H3

Upstream product

• 938-10-3 phenylsulfonyl azide 
• 108-88-3 toluene 
• 2101-86-2 p-methylazidobenzene 
• 98-09-9 benzenesulfonyl chloride 
• 106-49-0 p-toluidine 
• 98-10-2 benzenesulfonamide 
• 624-31-7 4-tolyl iodide 
• 108-98-5 thiophenol 
• 99-99-0 1-methyl-4-nitrobenzene 
• 873-55-2 sodium benzenesulfonate 
• 145490-75-1 N-fluorobenzene sulfonamide 
• 603-33-8 triphenylbismuthane 
• 2905-25-1 o-bromobenzenesulfonyl chloride 
• 1183123-34-3 2-bromo-N-p-tolylbenzenesulfonamide 

Downstream Products

• 1013511-26-6 benzenesulfonic acid-(2-chloro-4-methyl-anilide) 
• 940396-28-1 4-nitro-N-(phenylsulfonyl)-N-p-tolylbenzamide 
• 667875-40-3 N-(biphenyl-2-yl)-2-(N-(toluoyl)phenylsulfonamido)acetamide 
• 1521925-27-8 N-[4-(bromomethyl)phenyl]benzenesulfonamide 
• 5398-09-4 4-tolyl benzenesulfonate 
• 102157-40-4 (5-benzenesulfonylamino-2-methyl-phenyl)-malonic acid diethyl ester 
• 109596-96-5 benzenesulfonic acid-[3-(1-acetyl-2-oxo-propyl)-4-methyl-anilide] 
• 109257-16-1 5-benzenesulfonylamino-2-methyl-benzonitrile 
• 117309-38-3 (Benzenesulfonyl-p-tolyl-amino)-acetic acid 
• 96248-12-3 N-nitroso-p-methyl-benzenesulfonanilide 
• 95793-71-8 4-Methyl-2-(phenylsulfonyl)benzolamin 

Relevant articles and documents

Copper-Catalyzed Aminoarylation of Alkenes via Aminyl Radical Addition and Aryl Migration

We describe a new strategy for aminoarylation of alkenes by copper-catalyzed smiles rearrangement using O-benzoylhydroxylamines as the amine reagent. This method affords various β-amino amide derivatives possessing a quaternary carbon center with wide functional group tolerance and high regioselectivity. The mechanistic studies indicate that the transformation can involve aminyl radical intermediates under acid-free condition.

Synthesis of magnetic chitosan supported metformin-Cu(II) complex as a recyclable catalyst for N-arylation of primary sulfonamides

The application of chitosan, which has received much attention as a natural polymer and effective support, has many advantages such as biodegradability and biocompatibility. In this study, the immobilization of a copper complex on the magnetic chitosan bearing metformin ligand has been developed through immobilizing structurally defined metformin with long tail of (3-chloropropyl)trimethoxysilane (TMOS). The synthesized Fe3O4-chitosan@metformin-Cu(II) complex (Fe3O4-CS@Met-Cu(II)) was used as an effective, reusable and magnetic catalyst in the N-arylation of different derivatives of primary sulfonamides with arylboronic acids in ethanol. The primary sulfonamides were prepared from the reaction of sulfonyl chlorides with sodium cyanate in water under ultrasonic irradiation. Utilizing a wide variety of substrates in EtOH as a green solvent, high yields of the primary and secondary sulfonamides, easy work-up along with the excellent recovery and reusability of the catalyst, make this process a simple, economic and environmentally benign method. The synthesized Fe3O4-CS@Met-Cu(II) was characterized using various techniques such as XRD (X-ray diffraction), EDS (energy-dispersive X-ray spectroscopy), elemental mapping, TEM (transmission electron microscopy), FESEM (field emission scanning electron microscopy), VSM (vibrating sample magnetometer), ICP-MS (inductively coupled plasma mass spectroscopy), TGA (thermogravimetric analysis) and FT-IR (Fourier-transform infrared spectroscopy) analyses. The catalyst can be recycled and reused 5 times with no considerable loss of catalytic activity.

Straightforward Sulfonamidation via Metabisulfite-Mediated Cross Coupling of Nitroarenes and Boronic Acids under Transition-Metal-Free Conditions?

A straightforward multicomponent sulfonamidation of nitroarenes, sodium metabisulfite and boronic acids was established under transition-metal-free conditions to access diverse sulfonamides from readily available and low-cost materials modularly. Inorganic salt sodium metabisulfite not only served as a sulfur dioxide source, but also played a key role for both activator and reductant during sulfonamidation. Notably, naturally occurring biomolecules and pharmaceuticals with multiple heteroatoms and sensitive functional groups were intensively investigated in this transformtion providing versatile sulfonamides collectively. Further mechanistic studies demonstrated that nitrosoarene is the key intermediate, and the activation of boronic acid is the rate-determining step in the transformation.