632-12-2Relevant articles and documents
Unique polyhalogenated peptides from the marine sponge Ircinia sp.
Fernández, Rogelio,Bayu, Asep,Hadi, Tri Aryono,Bueno, Santiago,Pérez, Marta,Cuevas, Carmen,Putra, Masteria Yunovilsa
, (2020/08/28)
Two new bromopyrrole peptides, haloirciniamide A (1) and seribunamide A (2), have been isolated from an Indonesian marine sponge of the genus Ircinia collected in the Thousand Islands (Indonesia). The planar structure of both compounds was assigned on the basis of extensive 1D and 2D NMR spectroscopy and mass spectrometry. The absolute configuration of the amino acid residues in 1 and 2 was determined by the application of Marfey's method. Compound 1 is the first dibromopyrrole cyclopeptide having a chlorohistidine ring, while compound 2 is a rare peptide possessing a tribromopyrrole ring. Both compounds failed to show significant cytotoxicity against four human tumor cell lines, and neither compound was able to inhibit the enzyme topoisomerase I or impair the interaction between programmed cell death protein PD1 and its ligand, PDL1.
Chemical evolution of simple amino acids to asparagine under discharge onto the primitive hydrosphere: Simulation experiments using contact glow discharge
Munegumi, Toratane
, p. 1208 - 1215 (2015/02/19)
Asparagine is an important amino acid for abiotic polypeptide synthesis. In simulation experiments, it was obtained in 3.0% yield (based on the amount of consumed alanine) from alanine (100 mM) and formamide (200 mM) by contact glow discharge (Harada discharge) onto aqueous solutions. The present results suggest that asparagine could be abiotically synthesized from simple amino acids under possible primitive earth conditions.
Abiotic asparagine formation from simple amino acids by contact glow discharge electrolysis
Munegumi, Toratane,Shimoyama, Akira,Harada, Kaoru
, p. 393 - 394 (2007/10/03)
Asparagine, one of the most important amino acids for prebiotic peptide formation in aqueous media, was formed using Contact Glow Discharge Electrolysis (CGDE) against aqueous solutions containing simple amino acids and carboxylic acid amides.