DL-ISOSERINE

Base Information

• Chemical Name: DL-ISOSERINE
• CAS No.: 632-12-2
• Molecular Formula: C3H7NO3
• Molecular Weight: 105.093
• Hs Code.: 2922509090
• Mol file: 632-12-2.mol

Synonyms:3-Amino-2-hydroxy-propansulfonsaeure;3-amino-2-hydroxy-propane-1-sulfonic acid;3-amino-2-hydroxy-1-propanesulfonic acid;3-amino-2-hydroxypropionic acid;3-Amino-2-hydroxy-propan-1-sulfonsaeure;1-Propanesulfonic acid,3-amino-2-hydroxy;3-aminolactic acid;L-3-amino-2-hydroxypropanesulfonic acid;Hydroxyhomotaurine;

Chemical Property of DL-ISOSERINE

Chemical Property:

• Vapor Pressure: 1.43E-07mmHg at 25°C
• Melting Point: 235oC (dec.)(lit.)
• Refractive Index: 1.4368 (estimate)
• Boiling Point: 197.09°C (rough estimate)
• PSA: 83.55000
• Density: 1.3895 (rough estimate)
• LogP: -0.90910
• Storage Temp.: -15°C
• Water Solubility.: 15.3g/L(20 oC)

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-ISOSERINE

There total 16 articles about DL-ISOSERINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

formamide (77287-34-4,77287-35-5,60100-09-6) + 3-amino propanoic acid (107-95-9) → (RS)-isoserine (632-12-2) + isoasparagine (498-25-9) + glycine (56-40-6,18875-39-3,25718-94-9)

Guidance literature:

With sulfuric acid; In water; at 0 - 10 ℃; for 3h; contact glow discharge electrolysis;

DOI:10.1246/cl.1997.393

Reference yield:

haloirciniamide A → (S)-2,3-diaminopropionic acid (515-94-6,1915-96-4,4033-39-0,6018-54-8) + L-isoserine (565-71-9,632-11-1,632-12-2,632-13-3) + (2R)-aspartic acid (1783-96-6,25608-40-6,27881-03-4,32505-46-7,52526-39-3)

Guidance literature:

haloirciniamide A; With hydrogenchloride; In water; at 110 ℃; for 15h;

With sodium hydrogencarbonate; N-(2,4-dinitro-5-fluorophenyl)-L-alaninamide; In water; acetone; at 40 ℃; for 1h;

DOI:10.3390/MD18080396

Reference yield:

2,3-dibromopropionic acid (600-05-5) → 2,3-diaminopropanoic acid (515-94-6) + (RS)-isoserine (632-12-2)

Guidance literature:

With ammonium carbonate; ammonia; at 120 ℃; inactive α-oxy-β-amino-propionic acid;

upstream raw materials:

2,3-dibromopropionic acid

propylamine

formic acid

ethanolamine

Downstream raw materials:

glyceric acid

acetaldehyde

N-benzoyl-DL-isoserine

(3S)-α-<(p-benzyloxy)phenyl>-N-(diphenylmethyl)-3-hydroxy-2-oxo-1-azedineacetamide

Refernces

• 1、 Fukuhara, Kazuya,Takada, Kentaro,Watanabe, Ryuichi,Suzuki, Toshiyuki,Okada, Shigeru,Matsunaga, Shigeki. "Colony-wise Analysis of a Theonella swinhoei Marine Sponge with a Yellow Interior Permitted the Isolation of Theonellamide i". . p. 2595 - 2599. Retrieved 2018/12/13.
• 2、 Garcia, Jessica M.,Curzon, Stephanie S.,Watts, Katharine R.,Konopelski, Joseph P.. "Total synthesis of nominal (11S)- and (11R)-cyclocinamide A". supporting information; experimental part. p. 2054 - 2057. Retrieved 2012/06/29.