6329-54-0

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 121-45-9 phosphorous acid trimethyl ester 
• 10570-48-6 dimethyl 4-methoxybenzoylphosphonate 
• 100-07-2 4-methoxy-benzoyl chloride 
• 2033-24-1 cycl-isopropylidene malonate 
• 96-36-6 methyl phosphite 
• 36198-87-5 dimethyl trimethylsilyl phosphite 
• 868-85-9 Dimethyl phosphite 

Downstream Products

• 1000281-15-1 chloro-acetic acid (dimethoxy-phosphoryl)-(4-methoxy-phenyl)-methyl ester 
• 125172-85-2 P-[2-(4-methylphenyl)ethynyl] dimethyl phosphonate 
• 1352612-27-1 (dimethoxyphosphoryl)(4-methoxyphenyl)methyl cinnamate 
• 1332458-73-7 (dimethoxyphosphoryl)(4-methoxyphenyl)methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)benzoate 
• 63694-17-7 (4-methoxyphenyl)(hydroxy)methylphosphonic acid 
• 1208065-70-6 dimethyl [(2-methoxyphenyl)(6-oxo-6λ5-dibenzo[d,f][1,3,2]dioxaphosphepin-6-yl)ethyl]phosphonate 
• 79296-53-0 [Hydroxy-(4-methoxy-phenyl)-methyl]-phosphonic acid monomethyl ester 
• 694489-32-2 (2,4-dichloro-phenoxy)-acetic acid (dimethoxy-phosphoryl)-(4-methoxy-phenyl)-methyl ester 
• 79296-53-0 [Hydroxy-(4-methoxy-phenyl)-methyl]-phosphonic acid monomethyl ester 
• 1207757-83-2 O,O-dimethyl-2,6-pyridinyldi(formyloxy-4-methoxybenzylphosphonate) 

Relevant academic research and scientific papers

Biocatalytic Promiscuity of Lipases in Carbon-Phosphorus Bond Formation

A promiscuous lipase-catalyzed carbon-phosphorus bond formation is presented. The developed enzymatic Pudovik-Abramov reaction of various aromatic and aliphatic aldehydes with dialkyl phosphonates provides biologically and pharmacologically relevant α-hyd

Selective P?C(sp3) Bond Cleavage and Radical Alkynylation of α-Phosphorus Alcohols by Photoredox Catalysis

Herein the first P?C(sp3) bond cleavage and radical alkynylation of α-phosphorus alcohols to construct phosphonoalkynes is reported. The phosphorus radical is generated upon P?C bond cleavage reaction via the alkoxyl radical through photoredox catalysis with cyclic iodine(III) reagents. Various arylphosphinoyl-, alkylphosphinoyl-, phosphonate-, and phosphonic amide alcohols serve as radical phosphorus precursors to construct phosphonoalkynes for the first time.

Ultrasound assisted green synthesis of α-hydroxyphosphonates under solvent-free conditions

Abstract: A simple, efficient and environmentally benign method for the synthesis of α-hydroxyphosphonates by reaction of an aldehyde or a ketone, and trialkylphosphite is effectively accomplished under ultrasound irradiation and solvent-free and catalyst

Synthesis and insecticidal activities of O,O-dialkyl-2-[3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonyloxy] (aryl) methylphosphonates

A series of novel O,O-Dialkyl-2-[3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonyloxy](aryl) methy-lphosphonates I-1–14 were designed and synthesized. The structures of all the title compounds were confirmed by 1H-NMR, 13C-NMR, 31P-NMR, IR and elemental analysis. Their insecticidal activities against Mythimna separata and Plutella xylostella were evaluated. The results of bioassays indicated that the title compounds exhibited 20–80% larvicidal activity against Mythimna separata at 1000?mg/L.

Phospha-Michael Addition to in Situ Prepared 5-Arylmethylidene Meldrum's Acids

Knoevenagel condensation reaction of an aldehyde and Meldrum's acid produces a 5-arylmethylidene Meldrum's acid, which undergoes Michael addition of a trialkyl phosphite under solvent-free conditions to afford the title compounds in good yields.

Magnetic Fe3O4 nanoparticle-supported phosphotungstic acid as a recyclable catalyst for the kabachnik-fields reaction of isatins, imines, and aldehydes under solvent-free conditions

Magnetic-nanoparticle-supported phosphotungstic acid has been used to efficiently catalyze the hydrophosphonylation reaction of isatins, imines, and aldehydes using dimethyl and diethyl phosphite as a nucleophile to give the corresponding α-hydroxy and α-amino phosphonates in excellent yields for a wide range of substrates. The reaction conditions were simple, green, and efficient. The catalyst was recycled up to five times with retention of its activity. Based on the NMR spectroscopy studies, a probable catalytic cycle was proposed.

Synthesis, characterization and catalytic properties of magnetic nanoparticle supported guanidine in base catalyzed synthesis of α-hydroxyphosphonates and α-acetoxyphosphonates

Magnetic nanoparticle Fe3O4-immobilized guanidine (MNPs-Guanidine) as a novel magnetically interphase nanocatalyst was synthesized and characterized. MNPs-Guanidine catalyzed the synthesis of α-hydroxyphosphonates from aldehydes and

Synthesis and herbicidal activity of O,O-dimethyl-(3-phenacryloyloxy) alkyl phosphonates

In an attempt to discover novel compounds with high biological activity and low toxicity, a series of new O,O-dimethyl-(3-phenacryloyloxy) alkyl phosphonates 4a-m have been designed and synthesized by the reaction of 3-phenacryloyl chloride with α-hydroxyalkyl phosphonate. All new compounds were characterized by elemental analysis, IR, and 1H NMR spectroscopy as well as by mass spectrometry. The results of preliminary bioassay indicate that some of the target compounds have excellent inhibitory activities on Triticum aestivum (wheat) and Brassica napus L. (rape). Copyright Taylor and Francis Group, LLC.

MgCl2/Et3N base system as a new catalyst for the synthesis of α-hydroxyphosphonate

An efficient and simple synthesis of α-hydroxyphosphonates via reaction of aldehydes and ketones with dimethylphosphite in the presence of MgCl2/Et3N base system is reported. The use of readily available and easy to handle reagent MgCl2/Et3N makes this method simple, convenient, and practical. Copyright

Synthesis and herbicidal activity of novel dialkoxyphosphoryl aryl methyl 2-(4,6-dimethoxypyrimidin-2-yloxy) benzoate derivatives

A series of dialkoxyphosphoryl aryl methyl 2-(4,6-dimethoxy-pyrimidin-2- yloxy) benzoate derivatives was designed and synthesized. All new compounds were identified by elemental analysis, infrared (IR), 1H-NMR, and mass spectrometry (MS). Their herbicidal