63321-50-6

Basic information

• Product Name: 4-nitrophenyl N-butylcarbamate
• Synonyms: 4-nitrophenyl N-butylcarbamate
• CAS NO: 63321-50-6
• Molecular Formula: C₁₁H₁₄N₂O₄
• Molecular Weight: 238.24
• Mol File: 63321-50-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 355.5°C at 760 mmHg
• Flash Point: 168.8°C
• Appearance: /
• Density: 1.207g/cm³
• Vapor Pressure: 3.11E-05mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: 4-nitrophenyl N-butylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-nitrophenyl N-butylcarbamate(63321-50-6)
• EPA Substance Registry System: 4-nitrophenyl N-butylcarbamate(63321-50-6)

Safety Data

• Hazardous Substances Data: 63321-50-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H14N2O4/c1-2-3-8-12-11(14)17-10-6-4-9(5-7-10)13(15)16/h4-7H,2-3,8H2,1H3,(H,12,14)

Upstream product

• 7693-46-1 4-Nitrophenyl chloroformate 
• 109-73-9 N-butylamine 
• 100-02-7 4-nitro-phenol 
• 111-36-4 n-butyl isocyanide 

Downstream Products

• 100-02-7 4-nitro-phenol 
• 124-38-9 carbon dioxide 
• 109-73-9 N-butylamine 
• 108-95-2 phenol 

Relevant articles and documents

The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors

A series of para-substituted phenolic N-alkyl carbamates were evaluated for their FAAH and MGL inhibitory activities. The compounds were generally selective for FAAH, with IC50 values in the nM range, whereas inhibition of MGL required concentrations three orders of magnitude higher. The most potent compounds, dodecylcarbamic acid 4-(4,5-dihydrothiazol-2-yl)phenyl (12) and 4-(1,2,3-thiadiazol-4-yl)phenyl (26) esters, inhibited FAAH and MGL with IC50 values at the low-nanomolar (IC50s; 0.0063 and 0.012 μM) and the low-micromolar ranges (IC50s; 2.1 and 1.0 μM), respectively. Compound 26 also inhibited both FAAH-dependent AEA uptake and AEA hydrolysis (IC50; 0.082 μM) by intact RBL2H3 cells, and could also reduce 2-AG hydrolysis by these cells at concentrations ≥0.030 μM.

Structure-reactivity relationships as probes for the inhibition mechanism of cholesterol esterase by aryl carbamates. I. Steady-state kinetics

For substituted phenyl-N-butyl carbamates (1) and 4-nitrophenyl-N-substituted carbamates (2), linear relationships between values of NH proton chemical shift (δNH), pKa, and logk[OH] and Hammett substituent constant (σ) or Taft subst

Linear free energy relationships of the inhibition of pancreatic cholesterol esterase by 4-nitrophenyl-N-alkylcarbamate

4-Nitrophenyl-N-alkylcarbamates (1) as active site-directed irreversible inhibitors of pancreatic cholesterol esterase are investigated for values of the dissociation constant (K(i)), the carbamylation constant (k2), and the bimolecular rate co