6336-82-9

Usage

Uses

Used in Dye Manufacturing:
4-(Naphthalen-2-yl)phenol is used as a key component in the production of dyes, contributing to the development of colorants for various applications.
Used in Chemical Production:
4-(Naphthalen-2-yl)phenol is used as an intermediate in the synthesis of various chemicals, playing a crucial role in the chemical industry.

InChI:InChI=1/C16H12O/c17-16-9-7-13(8-10-16)15-6-5-12-3-1-2-4-14(12)11-15/h1-11,17H

Upstream product

• 91-20-3 naphthalene 
• 59115-45-6 2-(4-methoxyphenyl)naphthalene 
• 580-13-2 2-bromonaphthalene 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 628-13-7 pyridine hydrochloride 
• 106-41-2 4-bromo-phenol 
• 32316-92-0 naphthalene-2-boronic acid 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 540-38-5 p-Iodophenol 
• 930-68-7 cyclohexenone 

Downstream Products

• 933066-95-6 6-naphthalen-2-yl-2,2-diphenyl-2H-chromene 
• 612-94-2 2-phenylnaphthalene 
• 59115-49-0 2-(p-tolyl)naphthalene 

Relevant academic research and scientific papers

Synthesis of Fluorenes and Dibenzo[ g,p]chrysenes through an Oxidative Cascade

We have developed robust, operationally simple syntheses of fluorenes and of dibenzo[g,p]chrysenes through oxidative cascade processes. These structures that are commonly encountered in optoelectronic materials, dyes, and pharmaceutical products are acces

Pd-catalyzed protecting-group-free cross-couplings of iodophenols with atom-economic triarylbismuth reagents

An efficient protocol for the protecting-group-free synthesis of unsymmetrical hydroxybiaryls via the Pd-catalyzed cross-couplings of unprotected iodophenols with triarylbismuth reagents is described. The presented protocols exhibits good to high yields of hydroxybiaryls.

COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES

Disclosed herein are compounds and compositions for modulating glycolate oxidase, useful for treating oxalate-related diseases, such as hyperoxaluria, where modulating glycolate oxidase is expected to be therapeutic to a patent in need thereof. Methods of modulating glycolate oxidase activity in a human or animal subject is also provided.

An acetatopalladium(II) complex with 1-benzyl-N-(3,5-di-tert-butylsalicylidene)piperidin-4-amine: Synthesis, structure and catalytic applications in Suzuki–Miyaura coupling of arylboronic acids with hydroxyaryl halides

The Schiff base 1-benzyl-N-(3,5-di-tert-butylsalicylidene)piperidin-4-amine (HL) and its acetatopalladium(II) complex having the formula [Pd(L)(OAc)] were synthesized. Both HL and [Pd(L)(OAc)] were characterized using elemental analysis and various spectroscopic (infrared, UV–visible, 1H NMR and 13C NMR) and mass spectrometric measurements. The molecular structure of the complex was determined using X-ray crystallographic analysis. In the complex, the pincer-like NNO-donor L? and the monodenate OAc? provide a distorted square-planar N2O2 coordination environment around the metal centre. The physicochemical properties and the spectroscopic features of [Pd(L)(OAc)] are consistent with its molecular structure. The complex was found to be an effective catalyst for the Suzuki–Miyaura cross-coupling reactions of hydroxyaryl halides with arylboronic acids in predominantly aqueous media. The reactions afforded hydroxybiaryl products in good to excellent yields with a wide substrate scope.

Structure-activity relationship of synthetic 2-phenylnaphthalenes with hydroxyl groups that inhibit proliferation and induce apoptosis of MCF-7 cancer cells

In this study, six 2-phenylnaphthalenes with hydroxyl groups were synthesized in high yields by the demethylation of the corresponding methoxy-2-phenylnaphthalenes, and one 2-phenylnaphthalene with an amino group was obtained by hydrogenation. All of the

An alternative approach to para-C-H arylation of phenol: Palladium-catalyzed tandem γ-arylation/aromatization of 2-cyclohexen-1-one derivatives

An efficient approach to prepare para-aryl phenols has been developed by using a Pd-catalyzed tandem γ-arylation/aromatization of 2-cyclohexen-1-one derivatives with aryl bromides. This approach provides various p-aryl phenols from the phenol surrogates, 2-cyclohexen-1-one derivatives, in a single reaction step on the basis of C-H arylation.

The 1,3-diaminobenzene-derived aminophosphine palladium pincer complex {C6H3[NHP(piperidinyl)2]2Pd(Cl)} - A highly active Suzuki-Miyaura catalyst with excellent functional group tolerance

The rapidly prepared 1,3-diaminobenzenederived aminophosphine pincer complex {C6H3 [NHP(piperidinyl)2] 2Pd(Cl)} (1) is an effective Suzuki catalyst with excellent functional group tolerance. Side-product formations, such as homocoupling, debromation or protodeboration have only rarely been detected and if so, were in all cases below the 5% level. The presented reaction protocol is universally applicable. Experimental observations indicate that palladium nanoparticles are the catalytically active form of 1.

Photochromism of arylchromenes: Remarkable modification of absorption properties and lifetimes of o-quinonoid intermediates

(Chemical Equation Presented) A significant π-conjugation in 6- and 7-arylchromenes manifests dramatically in the absorption properties of their photogenerated o-quinonoid intermediates. This in conjunction with facile synthesis via Suzuki coupling may render a myriad of photochromic arylchromenes with wide-ranging spectrokinetic properties readily accessible.

ERβ ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERβ selectivity

The 2-phenylnaphthalene scaffold was explored as a simplified version of genistein in order to identify ER selective ligands. With the aid of docking studies, positions 1, 4, and 8 of the 2-phenylnaphthalene template were predicted to be the most potentially influential positions to enhance ER selectivity using two different binding orientations. Both orientations have the phenol moiety mimicking the A-ring of genistein. Several compounds predicted to adopt orientations similar to that of genistein when bound to ERβ were observed to have slightly higher ER affinity and selectivity than genistein. The second orientation we exploited, which was different from that of genistein when bound to ERβ, resulted in the discovery of several compounds that had superior ER selectivity and affinity versus genistein. X-ray structures of two ER selective compounds (i.e., 15 and 47) confirmed the alternate binding mode and suggested that substituents at positions 1 and 8 were responsible for inducing selectivity. One compound (i.e., 47, WAY-202196) was further examined and found to be effective in two models of inflammation, suggesting that targeting ER may be therapeutically useful in treating certain chronic inflammatory diseases.

Substituted phenyl naphthalenes as estrogenic agents

This invention provides estrogen receptor modulators of formula I, having the structure 1wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10, are as defined in the specification, or a pharmaceutically acceptable salt thereof.