63650-24-8

Upstream product

• 3307-39-9 2-(4-chlorophenoxy)propionic acid 
• 18671-89-1 cyclopropyl 4-(2-chlorophenoxy)butanoate 
• 78-89-7 2-chloro-1-propanol 
• 106-48-9 4-chloro-phenol 
• 4878-20-0 2-(4-Chlorophenoxy)propionic acid chloride 
• 4169-04-4 2-phenoxy-1-propanol 
• 95262-84-3 2-(4-chlorophenoxy)propanoic acid methyl ester 
• 75-56-9 methyloxirane 

Downstream Products

• 69183-35-3 {4-[2-(4-Chloro-phenoxy)-propoxy]-phenyl}-acetic acid methyl ester 
• 175442-03-2 2-(4-chlorophenoxy)propionaldehyde 
• 3307-39-9 2-(4-chlorophenoxy)propionic acid 
• 98919-13-2 2-(2,4-dichlorophenoxy)propan-1-ol 
• 120-36-5 2-(2,4-dichlorophenoxy)propionic acid 
• 82703-23-9 O-[2-(4-chlorophenoxy)propyl]hydroxylamine 
• 63650-13-5 2-(4-chlorophenoxy)-1-propanol O-methanesulfonate 
• 69183-42-2 {4-[2-(4-Chloro-phenoxy)-propoxy]-phenyl}-(4-trifluoromethyl-phenoxy)-acetic acid 
• 69183-39-7 (4-tert-Butyl-phenoxy)-{4-[2-(4-chloro-phenoxy)-propoxy]-phenyl}-acetic acid 
• 69183-41-1 (4-Chloro-phenoxy)-{4-[2-(4-chloro-phenoxy)-propoxy]-phenyl}-acetic acid 
• 69183-69-3 {4-[2-(4-Chloro-phenoxy)-propoxy]-phenyl}-acetic acid 

Relevant academic research and scientific papers

Cyclohexane-1,3-diketone compound as well as synthesis method and application thereof

The invention provides a cyclohexane-1,3-diketone compound of which the structural formula is shown in the specification, wherein the group R1 in the structural formula I is -CH3, -CH2CH3, -(CH2)2CH3,-CH(CH3)2, -(CH2)3CH3, -CH(CH3)C2H5, -CH2CH(CH3)2 or -C

A method for preparing chloro-benzene oxygen carboxylic acid (by machine translation)

The invention provides a method for preparing carboxylic acid chloro-benzene oxygen, comprising the following steps: S1) phenoxy fatty alcohol in the catalyst B A and under the action of the catalyst, and the chlorinating agent to 2 bit and/or 4 bit selective chlorination reaction, to obtain chloro-benzene oxygen fatty alcohol; said catalyst A is Lewis acid; said catalyst B is C5 - 22 of the thioether, thiazole, isothiazole, thiophene or their halogenated derivatives; S2) [...] fatty alcohol and water, under the action of a catalyst, and an oxidizing agent for the selective catalytic oxidation reaction, get chloro-benzene oxygen carboxylic acid. The invention through the re-design of the process route, the catalyst and the chlorinating agent fine screening, effectively reduces the energy consumption, the selectivity of the dichloride to improve at the same time avoiding the losses of the active ingredient, the resulting chloro-benzene oxygen carboxylic acid content can be up to 98.5% or more, the total yield can be up to 99% or more. (by machine translation)

Highly Enantioselective Hydrogenation of Amides via Dynamic Kinetic Resolution Under Low Pressure and Room Temperature

High-throughput screening and lab-scale optimization were combined to develop the catalytic system trans-RuCl2((S,S)-skewphos)((R,R)-dpen), 2-PrONa, and 2-PrOH. This system hydrogenates functionalized α-phenoxy and related amides at room temperature under 4 atm H2 pressure to give chiral alcohols with up to 99% yield and in greater than 99% enantiomeric excess via dynamic kinetic resolution.

An efficient catalyst for ring opening of epoxides with phenol and thiophenol under solvent-free conditions

An efficient and rapid procedure for ring opening reaction of various epoxides with phenol and thiophenol derivatives was developed. The procedure can be obtained at room temperature under solvent-free condition in presence of (C4H12N2)2[BiCl6] Cl·H2O (1 mol %). This catalyst can be reused several times without significant loss of activity.

Resolution of 2-aryloxy-1-propanols via lipase-catalyzed enantioselective acylation in organic media

2-Aryloxy-1-propanols, primary alcohols with an oxygen atom at the stereocenter, were resolved with good to high enantioselectivity by acylation with vinyl butanoate mediated by Pseudomonas sp. lipase in di-iso-propyl ether. Potential factors affecting the enantioselectivity of the enzymatic acylation were examined: solvents, acyl donors and temperature. Using this enantioselective acylation procedure, enantiomerically pure (R)-2-(4-chlorophenoxy)-1-propanol was prepared on a gram scale.

Reduced flexibility analogs of analgesic and cognition enhancing α-tropanyl esters

A series of semirigid analogs of compounds 1 and 2, two potent analgesics and cognition enhancers, have been synthesized and tested for antinociceptive activity (hot plate test) and for muscarinic affinity (binding in rat cerebral cortex). They were found to be in a general less potent than the reference compounds; only one of them (22) shows a good affinity for the muscarinic receptor and an antinociceptive efficacy comparable with those of the reference compounds. At a dose of 30 mg/kg 22 is also able to reverse the amnesic effect of dicyclomine. Since the analgesic effect of these compounds is affected by the 5-HT4 antagonist SDZ 205557, the possible role of this receptor is discussed.