63707-35-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
5-nitro-2-phenoxybenzonitrile is used as a chemical intermediate for the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and functional groups make it a valuable component in the development of new drugs and pesticides, contributing to the advancement of these industries.
Used in Research and Development:
In the field of research and development, 5-nitro-2-phenoxybenzonitrile serves as a key compound for studying the properties and reactions of nitrobenzene derivatives. Its potential applications in the synthesis of new compounds and its reactivity with other chemical entities make it an important subject of investigation for scientists and researchers.
Used in Safety and Environmental Studies:
Due to its potential respiratory sensitizing properties and toxicity to aquatic life, 5-nitro-2-phenoxybenzonitrile is used in safety and environmental studies to understand its impact on human health and the ecosystem. These studies help in developing guidelines and regulations for the safe handling, storage, and disposal of 5-nitro-2-phenoxybenzonitrile, as well as in assessing its environmental risks.
Used in Material Science:
5-nitro-2-phenoxybenzonitrile may also find applications in material science, particularly in the development of new materials with specific properties. Its unique structure and functional groups can be utilized to create novel materials with potential applications in various industries, such as electronics, coatings, and adhesives.

InChI:InChI=1/C13H8N2O3/c14-9-10-8-11(15(16)17)6-7-13(10)18-12-4-2-1-3-5-12/h1-8H

Upstream product

• 16588-02-6 4-chloro-3-cyanonitrobenzene 
• 108-95-2 phenol 
• 16588-15-1 2-chloro-5-nitro-benzamide 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 17417-09-3 2-fluoro-5-nitrobenzonitrile 
• 15267-98-8 sodium 4-aminophenolate 
• 100-00-5 4-chlorobenzonitrile 
• 873-32-5 2-Chlorobenzonitrile 

Downstream Products

• 288252-04-0 5-amino-2-phenoxy-benzonitrile 
• 731803-59-1 N-(2-Cycano-4-nitrophenyl)-n-butylamin 

Relevant academic research and scientific papers

AGRICULTURAL CHEMICALS

The present invention relates to picolinic acid derivatives that are useful in treating fungal diseases ofplants.

Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a promising therapeutic target for atherosclerosis, Alzheimer's disease, and diabetic macular edema. Here we report the identification of novel sulfonamide scaffold Lp-PLA2 inhibitors derived from a relatively weak fragment. Similarity searching on this fragment followed by molecular docking leads to the discovery of a micromolar inhibitor with a 300-fold potency improvement. Subsequently, by the application of a structure-guided design strategy, a successful hit-to-lead optimization was achieved and a number of Lp-PLA2 inhibitors with single-digit nanomolar potency were obtained. After preliminary evaluation of the properties of drug-likeness in vitro and in vivo, compound 37 stands out from this congeneric series of inhibitors for good inhibitory activity and favorable oral bioavailability in male Sprague-Dawley rats, providing a quality candidate for further development. The present study thus clearly demonstrates the power and advantage of integrally employing fragment screening, crystal structures determination, virtual screening, and medicinal chemistry in an efficient lead discovery project, providing a good example for structure-based drug design.

Synthesis and anti-CVB 3 evaluation of substituted 5-nitro-2-phenoxybenzonitriles

The synthesis and SAR of a series of 60 substituted 2-phenoxy-5-nitrobenzonitriles (analogues of MDL-860) as inhibitors of enterovirus replication (in particular of coxsackievirus B3 (CVB 3)) are reported. Several of the analogues inhibited CVB 3 and othe

AMIDE COMPOUNDS AND MEDICINAL USE THEREOF

The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.

Process for preparing nitrodiphenyl (thio) ethers

Nitrodiphenyl(thio) ethers in which the nitro group is in the ortho- or para-position with respect to the ether oxygen or ether sulphur can be prepared from halonitrobenzones in which the nitro group is in the ortho- or para-position with respect to the halogen and, alkali metal (thio)phenolates in liquid ammonia, the reaction being carried out under pressure and at a temperature from -30° C. to +140° C. and the ammonia being separated off after the reaction is completed.

Antipicornavirus activity of substituted phenoxybenzenes and phenoxypyridines

Phenoxybenzenes and phenoxypyridines were prepared and tested for the effect of substituents on antipicornavirus activity. The most active compound, 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (8), demonstrated broad-spectrum antipicornavirus activity. Co