64125-33-3

Usage

Uses

Used in Neurological Applications:
Isopongaflavone is used as a therapeutic agent for the treatment of neurological diseases such as Alzheimer's, stroke, paralysis, and dementia. Its presence in Fordiae Cauliflorae Radix contributes to the plant's traditional use in Chinese medicine for addressing these conditions.
Used in Traditional Chinese Medicine:
Isopongaflavone is used as a key component in traditional Chinese medicine formulations, where it plays a role in the treatment of various neurological disorders. Its natural occurrence in Fordiae Cauliflorae Radix makes it a valuable resource for developing herbal remedies and treatments.

Upstream product

• 93-89-0 benzoic acid ethyl ester 
• 25983-76-0 isoevodionol 
• 107-86-8 3,3-dimethyl acrylaldehyde 
• 3602-54-8 4,6-dihydroxy-2-methoxyacetophenone 
• 32550-59-7 6-Acetyl-5-hydroxy-7-methoxy-3,4-dihydro-2,2-dimethyl-2H<1>benzopyran 
• 34187-25-2 candidine 
• 77-78-1 dimethyl sulfate 
• 135940-08-8 5-Methoxy-8,8-dimethyl-2-phenyl-9,10-dihydro-8H-pyrano[2,3-f]chromen-4-one 
• 480-40-0 5,7-dihydroxy-2-phenyl-chromen-4-one 
• 31525-67-4 dimethylacetal of 3-methyl-3-hydroxybutyraldehyde 

Relevant academic research and scientific papers

New synthetic approaches to naturally occurring and unnatural pyranoflavones

Total synthesis of biologically interesting natural and unnatural pyranoflavones has been accomplished starting from readily available 2,4-dihydroxyacetophenone or 2,4-dihydroxy-6-methoxyacetophenone in three steps, i.e., benzopyran formation, condensatio

Synthesis of isopongaflavone

The synthesis of isopongaflavone1 9, a constituent of the seeds of Tephrosia bracteolata, is described. Phloroacetophenone 1 on treatment with chlorobutyne affords 2,6-dihydroxy-6′,6′-dimethyIpyrano[2′,3′: 4,3]acetophenone 2 which on methoxymethylation yields 2,6-di(methoxymethoxy)-6′, 6′-dimethylpyrano[2′,3′: 4,3]acetophenone 5. Alkaline condensation of 5 and benzaldehyde gives 2′, 6′-di(methoxymethoxy)-6″,6″-dimethylpyrano[2″, 3″ : 4′, 3′] chalcone 6. DDQ treatment of 2′, 6′-dihydroxy-6″,6″-dimethylpyrano[2″, 3″ : 4′, 3′] chalcone 7, obtained by the demethoxymethylation of 6, furnishes 5-hydroxy-6″,6″-dimethylpyrano[2″, 3″ : 4, 3]flavone 8 which on O-methylation gives 5-methoxy-6″,6″-dimethylpyrano[2″, 3″ : 4, 3]flavone 9.

A Facile Synthesis of Isopongaflavone, Atalantoflavone Dimethylether, Racemoflavone Dimethylether and their Analogues

A convenient route to pyranoflavones (natural and synthetic) from acetyl hydroxy chroman via the corresponding analogues by the use of Claisen condensation in the key step is reported.Keywords: 2-Aryl-8,8-dimethyl-6,7-dihydro-4H,8H-benzodipy