64152-77-8Relevant academic research and scientific papers
Solar and Visible Light Assisted Peptide Coupling
Mishra, Abhaya K.,Parvari, Galit,Santra, Sourav K.,Bazylevich, Andrii,Dorfman, Ortal,Rahamim, Jonatan,Eichen, Yoav,Szpilman, Alex M.
, p. 12406 - 12412 (2021/04/05)
Amino acid and peptide couplings are widely used in fields related to pharma and materials. Still, current peptide synthesis continues to rely on the use of expensive, water sensitive, and waste-generating coupling reagents, which are often prepared in mu
Modulating β-arrestin 2 recruitment at the δ- And μ-opioid receptors using peptidomimetic ligands
Altman, Ryan A.,Blaine, Arryn T.,Cassell, Robert J.,Cummins, Benjamin R.,Johnson, David K.,Meqbil, Yazan J.,Mores, Kendall L.,Sharma, Krishna K.,Su, Hongyu,Van Rijn, Richard M.
supporting information, p. 1958 - 1967 (2021/12/16)
μ-Opioid receptor agonists provide potent and effective acute analgesia; however, their therapeutic window narrows considerably upon repeated administration, such as required for treating chronic pain. In contrast, bifunctional μ/δ opioid agonists, such a
5-(1H-benzotriazol-1-yloxy)-3,4-dihydro-1-methyl 2H-pyrrolium hexachloroantimonate (BDMP): A highly efficient immonium type peptide coupling reagent
Li, Peng,Xu, Jie Cheng
, p. 1163 - 1164 (2007/10/03)
HOBt-based immonium type coupling reagent, 5-(1H-benzotriazol-1-yloxy)-3,4-dihydro-1-methyl 2H-pyrrolium hexachloroantimonate (BDMP) has been designed, synthesized and utilized to synthesize oligopeptides and biologically active peptides both in solution
SYNTHESIS OF CHIRAL OLIGOPEPTIDES BY MEANS OF CATALYTIC ASYMMETRIC HYDROGENATION OF DEHYDROPEPTIDES
Ojima, Iwao,Yoda, Noriko,Yatabe, Momoko,Tanaka, Toshiyuki,Kogure, Tetsuo
, p. 1255 - 1268 (2007/10/02)
Asymmetric hydrogenation of Ac-ΔTyr(Ac)-(S)-Ala-Gly-OMe (6), Ac-ΔTyr(Ac)-(R)-Ala-Gly-(S)-Phe-OMe (7), Ac-ΔPhe-NH-CH(R)-CH2-OCH2Ph (10), HCO-ΔPhe-(S)-Leu-OMe (16), X-AA-ΔPhe-AA'-OMe ( 5: X=tBOC, CBZ, CF3CO; AA, AA'= α-amino acid ), and t
On the Double Bond Isostere of the Peptide Bond: Preparation of an Enkephalin Analogue
Hann, Michael M.,Sammes, Peter G.,Kennewell, Peter D.,Taylor, John B.
, p. 307 - 314 (2007/10/02)
Methodology for preparing dipeptide analogues in which a carbon -carbon double bond replaces the normal amide bond is described.Thus, the protected tyrosylglycine analogue, (S)-trans-5-t-butyloxycarbonylamino-6-(4-t-butoxyphenyl)hex-3-enoic acid has been synthesised and incorporated into the Leu-enkephalin analogue (3) by condensation with glycylphenylalanyl-leucine.The enkephalin analogue retained biological activity.The significance of this isosteric replacement of the amide group is discussed.
SYNTHESIS OF CHIRAL TRIPEPTIDES BY ASYMMETRIC HYDROGENATION OF DEHYDROPEPTIDES. REMARKABLE EFFECTS OF N-PROTECTING GROUPS ON STEREOSELECTIVITY AND REACTIVITY
Ojima, Iwao,Yoda, Noriko
, p. 3913 - 3916 (2007/10/02)
Dehydrotripeptides, X-CH(Ri)-ΔPhe-CH(Rk)COOMe (3: X = tBOC-NH, CBZ-NH, CF3CONH and N3), were employed for the asymmetric hydrogenation catalyzed by chiral rhodium complexes and it was found that tBOC-3 brought a
SYNTHESIS OF ENKEPHALIN ANALOGS VIA ASYMMETRIC HYDROGENATION OF DEHYDROPEPTIDE BUILDING BLOCKS
Ojima, Iwao,Yoda, Noriko,Yatabe, Momoko
, p. 3917 - 3920 (2007/10/02)
1, D-Ala2, Leu5-OMe>Enkephalin and 1, D-Ala2, Leu5-OMe>Enkephalin were succesfully synthesized by the coupling of dipeptide units and tripeptide units which were readily obt
Evidence of the Preferential Involvement of μ Receptors in Analgesia Using Enkephalins Highly Selective for Peripheral μ or δ Receptors
Gacel, Gilles,Fournie-Zaluski, Marie-Claude,Fellion, Etienne,Roques, Bernard P.
, p. 1119 - 1124 (2007/10/02)
In order to study the preferential involvement of μ or δ receptors in the analgesic effects of enkephalins, several peptides which selectively interact with these two kinds of receptors in peripheral organs were synthesized.The inhibitory potency on the e
