93200-07-8

Upstream product

• 93199-88-3 ^tBOC-Gly-ΔPhe-(S)-Leu-NH2 
• 142955-50-8 N-(tert-butoxycarbonyl)-glycine N-carboxyanhydride 
• 4530-20-5 BOC-glycine 
• 124194-31-6 Boc-Gly-Δ^ZPhe azlactone 
• 108432-33-3 (S)-2-[(Z)-2-(2-tert-Butoxycarbonylamino-acetylamino)-3-phenyl-acryloylamino]-4-methyl-pentanoic acid 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 64152-77-8 N-(tert-butyloxycarbonyl)glycyl-L-phenylalanyl-L-leucine methyl ester 
• 74257-73-1 tert-butyl ((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 10466-61-2 (2S)-amino-4-methylpentanamide hydrochloride 
• 81638-86-0 (S)-2-((S)-2-amino-3-phenylpropanamido)-4-methylpentanamide hydrochloride 
• 147781-99-5 Boc-Gly-DL-Phe(β-OH)-OH 
• 42267-16-3 (d,l)-phenylserine ethyl ester hydrochloride 
• 89093-60-7 2-(2-tert-Butoxycarbonylamino-acetylamino)-3-hydroxy-3-phenyl-propionic acid ethyl ester 
• 90761-06-1 ^tBOC-Gly-ΔPhe-(S)-Leu-OMe 

Downstream Products

• 1313481-74-1 Boc-Tyr(tBu)-Gly-Gly-Phe-Leu-NH₂ 
• 82948-92-3 [des-tyr¹]-leucine enkephalinamide 
• 81638-87-1 hydrochloride of amide of glycylglycyl-L-phenylalanyl-L-leucine 
• 75286-46-3 amide of N-t-butyloxycarbonylglycylglycyl-L-phenylalanyl-L-leucine 

Relevant academic research and scientific papers

Environmentally Conscious In-Water Peptide Synthesis Using Boc Strategy

Seeking a more environmentally balanced method of peptide synthesis, we are focusing on developing organic solvent-free synthetic methods using water, an environmentally friendly solvent. In current peptide synthesis, the most common building blocks are Boc- and Fmoc-protected amino acids, which are highly soluble in organic solvents. We previously reported a technique for solid-phase peptide synthesis in water that utilizes Fmoc-amino acids converted to water-dispersible nanoparticles. The Boc strategy is well-known to be suitable for the industrial chemistry and green chemistry, because only gases are generated without any other by-products in the deprotection step of Boc group. Here we summarize in-water both liquid and solid-phase method using Boc-amino acids based on MW-assisted coupling reaction of nanosized reactants, nanoparticles and nanomicelles.

Modulating β-arrestin 2 recruitment at the δ- And μ-opioid receptors using peptidomimetic ligands

μ-Opioid receptor agonists provide potent and effective acute analgesia; however, their therapeutic window narrows considerably upon repeated administration, such as required for treating chronic pain. In contrast, bifunctional μ/δ opioid agonists, such a

Peptide synthesis 'in water' by a solution-phase method using water-dispersible nanoparticle Boc-amino acid

Regulatory pressure has compelled the chemical manufacturing industry to reduce the use of organic solvents in synthetic chemistry, and there is currently a strong focus on replacing these solvents with water. Here, we describe an efficient in-water solution-phase peptide synthesis method using Boc-amino acids. It is based on a coupling reaction utilizing suspended water-dispersible nanoparticle reactants. Using this method, peptides were obtained in good yield and with high purity.

Rapid, one-pot synthesis of urethane-protected tripeptides

Urethane-protected tripeptides are synthesized in solution, without isolation of purification of intermediates, using urethane-protected N-carboxyanhydrides as coupling reagents and hydrogenation for removal of N-protection.

SYNTHESIS OF CHIRAL OLIGOPEPTIDES BY MEANS OF CATALYTIC ASYMMETRIC HYDROGENATION OF DEHYDROPEPTIDES

Asymmetric hydrogenation of Ac-ΔTyr(Ac)-(S)-Ala-Gly-OMe (6), Ac-ΔTyr(Ac)-(R)-Ala-Gly-(S)-Phe-OMe (7), Ac-ΔPhe-NH-CH(R)-CH2-OCH2Ph (10), HCO-ΔPhe-(S)-Leu-OMe (16), X-AA-ΔPhe-AA'-OMe ( 5: X=tBOC, CBZ, CF3CO; AA, AA'= α-amino acid ), and t