6436-58-4

Basic information

• Product Name: 4-Thiazolecarboxylic acid, 4,5-dihydro-2-methyl-, methyl ester
• Synonyms: 2-methyl-4,5-dihydro-thiazole-4-carboxylic acid methyl ester;2-Methyl-2-thiazolin-carbonsaeure-(4)-methylester;2-Methyl-Δ2-thiazolin-4-carbonsaeure-methylester;rac.-2-Methyl-2-thiazolin-4-carbonsaeure-methylester;2-Methyl-2-thiazolin-4-carbonsaeure-methylester;2-Methyl-Δ2-thiazolin-carbonsaeure-(4)-methylester
• CAS NO: 6436-58-4
• Molecular Formula: C6H9NO2S
• Molecular Weight: 159.209
• Mol File: 6436-58-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 22-24 °C
• Boiling Point: 65-69 °C(Press: 3 Torr)
• Density: 1.30±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 4-Thiazolecarboxylic acid, 4,5-dihydro-2-methyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Thiazolecarboxylic acid, 4,5-dihydro-2-methyl-, methyl ester(6436-58-4)
• EPA Substance Registry System: 4-Thiazolecarboxylic acid, 4,5-dihydro-2-methyl-, methyl ester(6436-58-4)

Safety Data

• Hazardous Substances Data: 6436-58-4(Hazardous Substances Data)

Upstream product

• 1084772-05-3 C₆H₁₁NO₃S 
• 190601-71-9 2-methyl-4,5-dihydrothiazole-4-carboxylic acid 
• 74-88-4 methyl iodide 
• 2485-62-3 L-Cysteine methyl ester 
• 1000-84-6 O-ethyl acetimidate 
• 2208-07-3 ethyl acetimidate hydrochloride 
• 18598-63-5 L-cysteine methyl ester hydrochloride 
• 116077-24-8 S-<2-Chlor-2-(methoxycarbonyl)ethyl>thioacetamid-hydrochlorid 
• 5714-80-7 cysteine methyl ester hydrochloride 
• 1393377-75-7 dimethyl (2R,2'R)-3,3'-disulfanediylbis(2-azidopropanoate) 
• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 

Downstream Products

• 52-89-1 l-cysteine hydrochloride 
• 6436-60-8 methyl 2-methyl-1,3-thiazole-4-carboxylate 

Relevant articles and documents

Method for preparing 2,4-disubstituted thiazoline compound from acyl chloride

The invention provides a novel method for preparing 2,4-disubstituted thiazoline at high yield by firstly reacting acyl chloride serving as a raw material and beta-azide disulfide and also provides a general formula I and application of a product, namely a 2,4-disubstituted thiazoline compound. By using the method, the defects of synthesis complexity, high byproduct yield and slightly low yield of the existing method are overcome, and the method has the advantages of high yield (up to 90% or above), high repeatability and suitability for preparation on a relatively large scale.

Concise synthesis of 2,4-disubstituted thiazoles from β-azido disulfides and carboxylic acids or anhydrides: Asymmetric synthesis of cystothiazole C

A novel and efficient method for the one-pot synthesis of 2,4-disubstituted thiazoles from carboxylic acids or anhydrides is presented. Based on this new method, the total synthesis of the bis-2,4-disubstituted bis(thiazoles) natural product cystothiazole C is also presented. This journal is

One-pot synthesis of 2,4-disubstituted thiazoline from β-azido disulfide and carboxylic acid

A concise and efficient one-pot four-step synthesis of 2,4-disubstituted thiazoline via a cascade disulfide bond cleavage/thiocarbonylation/Staudinger reduction/aza-Wittig reaction is established. Treatment of various carboxylic acids with β-azido disulfides under this one-pot procedure obtained the desired thiazolines in good to excellent isolated yields.