64360-24-3

Upstream product

• 4173-74-4 1-Phenyl-3-methyl-4-acetyl-5-pyrazolon 
• 141-78-6 ethyl acetate 
• 54107-17-4 3-(2-phenylhydrazonoethyl)-4-hydroxy-6-methylpyrone-2-one 
• 87100-61-6 3-methyl-4-(acetacetyl)-1-phenyl-2-pyrazolin-5-one 
• 87100-61-6 1-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)butane-1,3-dione 
• 89-25-8 edaravone 
• 37703-59-6 1-phenyl-3-methyl-4-acetylpyrazol-5-one 
• 771-03-9 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one 
• 54107-17-4 4-hydroxy-6-methyl-3-[(1E)-1-(2-phenylhydrazinylidene)ethyl]-2H-pyran-2-one 
• 100-63-0 phenylhydrazine 

Relevant academic research and scientific papers

Synthesis, Anti-Inflammatory Activity, and COX-1/2 Inhibition Profile of Some Novel Non-Acidic Polysubstituted Pyrazoles and Pyrano[2,3-c]pyrazoles

The synthesis and evaluation of the anti-inflammatory activity of some structure hybrids comprising basically the 5-hydroxy-3-methyl-1-phenyl-4-substituted-1H-pyrazole scaffold directly linked to a variety of heterocycles and functionalities, or annulated

Synthesis of some pyrano[2,3-c]pyrazoles

Synthetic methods have been developed to prepare pyrano[2,3-c]pyrazoles with various substituents at ring positions 1, 3, and 6. The 1H- and 13C-NMR properties of these products and their precursors are presented and discussed.

Pyranopyrazoles III synthesis of 1H-pyrano[2,3-c]pyrazol-4-ones [1]

Various derivatives of title ring system were synthesized by Claisen condensation of 4 acetyl-5-hydroxypyrazoles with appropriate esters, followed by acid-catalyzed ring closure.

Synthesis of bipyrazoles and pyrazoloisoxazoles from 3-acetyl-4- hydroxy-6-methyl-2H-pyran-2-one

Phenylhydrazine or hydrazine react with 3-acetyl-4-hydroxy-6-methyl-2H- pyran-2-one (1) to give 4-acetoacetyl-3-methylpyrazolin-5-ones 4. The synthesis of bipyrazoles and pyrazoloisoxazoles from 4 are reported.

Synthesis and A1 and A(2A) adenosine binding activity of some pyrano[2,3-c]pyrazol-4-ones

A series of pyrano[2,3-c]pyrazol-4-ones was synthesized and evaluated for bovine brain adenosine A1 and A(2A) receptor binding affinity. Substituents at positions 5 and/or 6 were varied in order to define the structure-activity relationships in

Novel synthesis of 6-ethoxy-6-methyl-5,6-dihydropyranopyrazol-4-ones

The Claisen reaction of 4-acetyl-5-methoxypyrazole derivatives (2a-c) with ethyl acetate in the presence of pulverized sodium afforded 6-ethoxy-6-methyl-5,6-dihydropyranopyrazol-4-ones (4a-c) instead of the expected 1H-pyranopyrazol-4-ones (

Synthesis of Pyranopyrazol-4(1H)-ones and -4(2H)-ones from Dehydroacetic Acid. Homo- and Heteronuclear Selective NOE Measurements for Unambiguous Structure Assignment

Cyclization of dehydroacetic acid N-substituted hydrazones furnished 1-substituted 3,6-dimethylpyranopyrazol-4(1H)-ones, together with varying amounts of N,N'-disubstituted 5-hydroxy-3-methyl-4-(3-methyl-1H-pyrazol-5-yl)-1H-pyrazoles.The same pyranopyrazolones were obtained regioselectively without side reactions from N-alkylhydrazines and 4-chloro-3-(1-chlorovinyl)-6-methyl-2H-pyran-2-one, ("Dehydroacetchlorid"), while N-arylhydrazines gave the 2-aryl-3,6-dimethylpyranopyrazol-4(2H)-ones.NMR NOE methods, including long-range selective heteronuclear 13C NOE enhancement measurements, allowed unambiguous between -4(1H)-ones and -4(2H)-ones.

Synthesis of 4-(Acylacetyl)-1-phenyl-2-pyrazolin-5-ones from 3-Acyl-2H-pyran-2,4(3H)-diones. Their Synthetic Applications to Functionalized 4-Oxopyranopyrazole Derivatives.

The phenylhydrazones of 3-acyl-2H-pyran-2,4(3H)-diones (2), in refluxing acetic acid, underwent rearrangement to 4-(acylacetyl)-1-phenyl-2-pyrazolin-5-ones (6), from which some functionalized 4-oxopyranopyrazole derivatives were synthesized.This fi