64479-84-1Relevant articles and documents
Transaminase-Mediated Amine Borrowing via Shuttle Biocatalysis
O'Reilly, Elaine,O'Sullivan, Rachel,Ryan, James,Taday, Freya
supporting information, (2022/01/04)
Shuttle catalysis has emerged as a useful methodology for the reversible transfer of small functional groups, such as CO and HCN, and goes far beyond transfer hydrogenation chemistry. While a biocatalytic hydrogen-borrowing methodology is well established, the biocatalytic borrowing of alternative functional groups has not yet been realized. Herein, we present a new concept of amine borrowing via biocatalytic shuttle catalysis, which has no counterpart in chemo-shuttle catalysis and allows efficient intermolecular amine shuttling to generate reactive intermediates in situ. By coupling this dynamic exchange with an irreversible downstream step to displace the reaction equilibrium in the forward direction, high conversion to target products can be achieved. We showcase the potential of this amine-borrowing methodology using a biocatalytic equivalent of both the Knorr-pyrrole synthesis and Pictet-Spengler reaction.
Crystal form of L-lysinate of benzopiperidine derivative and preparation method thereof
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Paragraph 0076; 0080-0082, (2020/07/15)
The invention provides a crystal form of a L-lysinate of a benzopiperidine derivative and a preparation method of the crystal form. Specifically, the invention provides a crystal form II of L-lysinateof (E)-3-(4-((1R, 3R)-2-(4-cyclopropyl phenyl)-6-(1-ethyl-1H-pyrazol-4-yl)-3-methyl-1, 2, 3, 4-tetrahydroisoquinoline-1-yl) phenyl) acrylate and a preparation method of the crystal form II. The crystal form II of the compound shown in the formula (I) has good stability and can be better applied to clinical treatment.
Compositions and methods for determining the presence of amphetamines in a sample suspected of containing amphetamine and/or methamphetamine
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, (2008/06/13)
The instant invention is directed toward an immunoassay which can determine the presence of amphetamines in a sample suspected of containing amphetamine and/or methamphetamine by employing at least two conjugates, each comprised of a functionally similar label bound to an amphetamine analog and a methamphetamine analog respectively and an antibody to amphetamine and an antibody to methamphetamine wherein at least one of the antibodies is a monoclonal antibody.