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(2Z)-3-(3,4-dimethylphenyl)-2-[(3,4-dimethylphenyl)imino]-5-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-1,3-thiazolidin-4-one, also known as darglitazone, is a thiazolidine derivative with potential antidiabetic activity. It is a synthetic compound that acts as an agonist at the peroxisome proliferator-activated receptor gamma (PPAR-γ) in adipose tissue and muscle, promoting insulin sensitivity and glucose uptake. Its chemical structure contains a thiazolidine ring, a phenyl group, and a hydroxy-dimethoxyphenylmethylidene group, which are all important for its biological activity.

6453-93-6

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Basic information
1. Product Name: (2Z)-3-(3,4-dimethylphenyl)-2-[(3,4-dimethylphenyl)imino]-5-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-1,3-thiazolidin-4-one
2. Synonyms:
3. CAS NO:6453-93-6
4. Molecular Formula: C₂₁H₁₄O
5. Molecular Weight: 488.5979
6. EINECS: N/A
7. Product Categories: N/A
Chemical Properties
1. Melting Point: N/A
2. Boiling Point: 685.1°C at 760 mmHg
3. Flash Point: 368.1°C
4. Appearance: N/A
5. Density: 1.21g/cm³
6. Vapor Pressure: 2.14E-19mmHg at 25°C
7. Refractive Index: 1.612
8. Storage Temp.: N/A
9. Solubility: N/A
10. CAS DataBase Reference: (2Z)-3-(3,4-dimethylphenyl)-2-[(3,4-dimethylphenyl)imino]-5-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-1,3-thiazolidin-4-one(CAS DataBase Reference)
11. NIST Chemistry Reference: (2Z)-3-(3,4-dimethylphenyl)-2-[(3,4-dimethylphenyl)imino]-5-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-1,3-thiazolidin-4-one(6453-93-6)
12. EPA Substance Registry System: (2Z)-3-(3,4-dimethylphenyl)-2-[(3,4-dimethylphenyl)imino]-5-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-1,3-thiazolidin-4-one(6453-93-6)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 6453-93-6(Hazardous Substances Data)

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6453-93-6 Usage

Uses

Used in Pharmaceutical Industry:
Darglitazone is used as an antidiabetic agent for the treatment of type 2 diabetes and related metabolic disorders. It modulates the activity of peroxisome proliferator-activated receptor gamma (PPAR-γ), enhancing insulin sensitivity and glucose uptake in adipose tissue and muscle, thereby improving blood sugar control and reducing insulin resistance.
Used in Drug Development:
Darglitazone is being studied for its potential as a therapeutic agent in the development of new drugs for the treatment of type 2 diabetes and related metabolic disorders. Its unique chemical structure and mechanism of action make it a promising candidate for further research and development in the pharmaceutical industry.

Check Digit Verification of cas no

The CAS Registry Mumber 6453-93-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,4,5 and 3 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6453-93:
(6*6)+(5*4)+(4*5)+(3*3)+(2*9)+(1*3)=106
106 % 10 = 6
So 6453-93-6 is a valid CAS Registry Number.

6453-93-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name	phenanthren-1-yl(phenyl)methanone

1.2 Other means of identification

Product number	-
Other names	Methanone, 1-phenanthrenylphenyl-

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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