64718-13-4

Basic information

• Product Name: AcetaMide, N-(2-cyanophenyl)-2,2,2-trifluoro-
• Synonyms: AcetaMide, N-(2-cyanophenyl)-2,2,2-trifluoro-
• CAS NO: 64718-13-4
• Molecular Formula: C₉H₅F₃N₂O
• Molecular Weight: 214.1440096
• Mol File: 64718-13-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: AcetaMide, N-(2-cyanophenyl)-2,2,2-trifluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: AcetaMide, N-(2-cyanophenyl)-2,2,2-trifluoro-(64718-13-4)
• EPA Substance Registry System: AcetaMide, N-(2-cyanophenyl)-2,2,2-trifluoro-(64718-13-4)

Safety Data

• Hazardous Substances Data: 64718-13-4(Hazardous Substances Data)

Upstream product

• 354-32-5 trifluoracetyl chloride 
• 1885-29-6 anthranilic acid nitrile 
• 544-92-3 copper(I) cyanide 
• 143321-89-5 2,2,2-trifluoro-N-(2-iodophenyl)acetamide 
• 615-43-0 2-iodophenylamine 
• 62-53-3 aniline 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 107288-98-2 4-phenyl-2-(trifluoromethyl)quinazoline 
• 52353-35-2 4-chloro-2-trifluoromethyl quinazoline 
• 607-68-1 2,4-dichloroquinazoline 
• 1885-29-6 anthranilic acid nitrile 

Relevant articles and documents

Pd-Catalyzed tandem reaction of N-(2-cyanoaryl)benzamides with arylboronic acids: synthesis of quinazolines

The synthesis of 2,4-disubstituted quinazolines by a palladium-catalyzed reaction of arylboronic acids with N-(2-cyanoaryl)benzamides has been developed with moderate to excellent yields. The method shows good functional group tolerance. In particular, ha

Acetonitrile-mediated synthesis of 2,4-dichloroquinoline from 2-ethynylaniline and 2,4-dichloroquinazoline from anthranilonitrile

2,4-Dichloroquinolines and 2,4-dichloroquinazolines were synthesized from 2-ethynylanilines and anthranilonitriles, respectively, using diphosgene in acetonitrile and heating at 130 °C or 150 °C for 12 hours. This reaction was applied to the synthesis of 4,6-dichloropyrazolo[3,4-d]pyrimidine (dichloro-9H-isopurine). The postulated mechanism is also described. Georg Thieme Verlag Stuttgart.

SYNTHESE ET CARACTERISTIQUES SPECTRALES DE F-ALKYL-2-DIHYDRO-3,4 OXO-4 QUINAZOLINES

In this paper we report the preparation of a series of 4(3H) quinazolinones substituted in the 2 position by a linear perfluoroalkyl-chain with RF as Cn F2n+1 (n=1,3,5,7).These compounds are obtained in two steps, action of F-acid chlorides on 2-aminobenzonitrile which affords the corresponding F-amides followed by cyclization of this intermediate with alkaline hydrogen peroxide.We isolated a reaction intermediate in the cyclization of N-(2-cyanophenyl)F-octanamide.All compounds were identified by the usual spectroscopic methods (IR, NMR 1H, 19F, mass spectrometry).