65405-67-6

Usage

Preparation

By formylation of the corresponding olefin.

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 123-38-6 propionaldehyde 
• 100-66-3 methoxybenzene 
• 78-84-2 isobutyraldehyde 
• 25679-28-1 cis-Anethole 
• 68-12-2 N,N-dimethyl-formamide 
• 14674-38-5 N-(4-methoxybenzylidene)-p-toluenesulfonamide 
• 107-18-6 allyl alcohol 
• 139711-00-5 1-(4-methoxyphenyl)-2-methyl-2-propen-1-ol 
• 139710-95-5 1-(p-methoxyphenyl)-1,2-dibromo-2-methylpropane 
• 877-99-6 1-methoxy-4-(2-methyl-1-propenyl)benzene 
• 139711-01-6 (Z)-3-(4-Methoxy-phenyl)-2-methyl-prop-2-en-1-ol 
• 4180-23-8 E-1-(4'-methoxyphenyl)prop-1-ene 

Downstream Products

• 105157-59-3 3t-(4-methoxy-phenyl)-2-methyl-acrylaldehyde-oxime 
• 1589518-75-1 N-(6-methoxy-2-methyl-1H-inden-1-yl)-4-methylbenzenesulfonamide 
• 1564277-31-1 N-(2-(4-methoxyphenyl)-3-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-1(2H)-yl)benzamide 
• 1564277-26-4 2-(4-methoxyphenyl)-3-methyl-1-(phenylamino)-1,2,7,8-tetrahydroquinolin-5(6H)-one 
• 1491166-58-5 C₂₃H₂₂O₃ 
• 1491166-55-2 C₁₇H₁₈O₃ 
• 1449584-19-3 2-(4-methoxyphenyl)-3-methyl-7,7-diphenyl-7,8-dihydropyrano[4,3-b]pyran-5(2H)-one 
• 1491165-78-6 C₂₄H₂₄O₆ 
• 1491165-71-9 C₂₂H₁₉FO₄ 

Relevant academic research and scientific papers

Synthesis method of cinnamyl aldehyde compound

The invention discloses a synthesis method of a cinnamyl aldehyde compound. The cinnamyl aldehyde compound is synthesized through the crossed dehydrogenation coupling reaction with fatty aldehyde andsbstituted sromatic hydrocarbon as the initial raw materials and palladium chloride and amino acid as the catalysts. Compared with a traditional cinnamyl aldehyde compound synthesis method, the methodis simple in operation, mild in reaction condition, low in applied reagent price, high in efficiency and high in atom utilization rate.

Preparation method for cinnamaldehyde and derivatives thereof

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method for cinnamaldehyde and derivatives thereof. The preparation method includes taking styrene or derivatives thereof as a substrate, reacting the substrate with a formamide solvent, iodoform and alkali at a certain temperature and under the protection of argon, and completing carbonylation to generate target products, namely the cinnamaldehyde and the derivatives thereof. The preparation method of the cinnamaldehyde and the derivatives thereof has the advantages of low cost and easyavailability of raw materials, no metal catalysis, environmental friendliness, high reaction yield and the like, thereby having a good industrial application prospect.

Poly(phosphoric acid) (PPA)-Promoted 5- exo -Cyclization of Iminium Ions Generated in Situ: A Facile Access to Functionalized Indene Derivatives

A metal-free Bronsted acid promoted two-component reaction between cinnamaldehydes and sulfonamides is described. This cascade process provides a simple and atom-economical alternative synthesis of a range of functionalized indenes from easily available starting materials. The resulting N -indenylsulfonamides were readily converted into the corresponding indenylenamines or indanones.

Pd/Al2O3-catalysed redox isomerisation of allyl alcohol: Application in aldol condensation and oxidative heterocyclization reactions

The application of the Pd/Al2O3 catalyst in allyl alcohol isomerization and subsequent aldol condensation and heterocyclization reactions is described. The activity of Pd/Al2O3 in these transformations is suggested to be due to the participation of the Lewis acidic sites of the support in the activation of the alcohol towards oxidative dehydrogenation by the metal and subsequent hydride transfer. The resulting enol(ate)/aldehyde could undergo further reactions promoted by the acid-base properties of the support. In the aldol condensation reactions of the isomerization product, electron poor aromatic aldehydes and heteroaromatic aldehydes showed the highest activity, while aromatic aldehydes bearing electron donating substituents reacted after transformation to the corresponding N-tosyl imines. 1,2-Disubstituted aromatics gave heterocyclic products in one-pot multistep reaction sequences.

Use of n-substituted (3,6-dihydro)-2h-1,2-oxazine derivatives as selective mglur1 antagonists

STR1Use of a compound of formula (I) in which, R 1, R 2 and R 3 are independently hydrogen, (C 1 -C 6)alkyl, (C 2 -C 6)alkenyl, C 3 -C 10)cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted aryl(C 1 -C 6)alkyl, unsubstituted or substituted aryl(C 2 -C 6)alkenyl, halo, carboxy, (C 1 -C 6)alkoxycarbonyl or --(CH 2) m --OH wherein m is 1, 2 or 3; - - - indicates a single or a double bond; X and each independently hydrogen, or X and Y together represent a bridge of the formula --CH 2) m --, where n is 1 or 2; A 1 and A 2 are each independently an unsubstituted or substituted aryl; Z is --CO--, --SO 2 -- or --CH 2 ; provided that, when Z is --CO--, A 1 is not 3,4,5-trimethoxyphenyl; or a pharmaceutically-acceptable salt or ester thereof, for the manufacture of a medicament for the treatment of a condition indicating the administration of a selective mGluR1 antagonist.

Neighbouring group participation in the solvolysis of a class of heterocyclic and acyclic trans-dibromides and bromohydrins

Solvolysis of heterocyclic trans-dibromides and bromohydrins 1a-e affords the ring contracted aldehydes 10a-c and the benzthiophen derivative 11.The acyclic dibromide 2a similarly provides the expected aldehyde 13.Probable pathways for the formation of the products have been presented.