6621-97-2

Basic information

• Product Name: 3-hydroxy-2,3-diphenyl-2,3-dihydro-1H-isoindol-1-one
• CAS NO: 6621-97-2
• Molecular Formula: C₂₀H₁₅NO₂
• Molecular Weight: 301.3386
• Mol File: 6621-97-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 514.8°C at 760 mmHg
• Flash Point: 265.1°C
• Density: 1.31g/cm³
• Vapor Pressure: 2.02E-11mmHg at 25°C
• Refractive Index: 1.69
• CAS DataBase Reference: 3-hydroxy-2,3-diphenyl-2,3-dihydro-1H-isoindol-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-2,3-diphenyl-2,3-dihydro-1H-isoindol-1-one(6621-97-2)
• EPA Substance Registry System: 3-hydroxy-2,3-diphenyl-2,3-dihydro-1H-isoindol-1-one(6621-97-2)

Safety Data

• Hazardous Substances Data: 6621-97-2(Hazardous Substances Data)

Upstream product

• 520-03-6 N-phenylphthalimide 
• 108-86-1 bromobenzene 
• 36149-35-6 3-anilino-3-phenyl-3H-isobenzofuran-1-one 
• 487-42-3 N-Phenylphthalisoimid 
• 71-43-2 benzene 
• 110474-85-6 2-(2-chloro-1-phenyl-vinyl)-benzoic acid anilide 
• 18852-53-4 3-chloro-3-phenylphthalide 
• 62-53-3 aniline 
• 55810-66-7 2-(benzyl)benzoyl chloride 
• 90292-79-8 2-benzyl-N-phenylbenzamide 
• 6630-33-7 ortho-bromobenzaldehyde 
• 59142-47-1 (2-bromophenyl)phenylmethanol 
• 23450-18-2 2-benzyl-1-bromobenzene 
• 612-35-1 2-Benzylbenzoic acid 

Downstream Products

• 102242-28-4 3-benzyl-3-phenyl-3H-isobenzofuran-1-one 
• 132501-14-5 1,3-di-hydroxy-1,2,3-triphenylphtalimidine 
• 5004-45-5 4-phenyl-2H-phthalazin-1-one 
• 123217-56-1 2,3-diphenylisoindoline-1-thione 
• 5398-11-8 3-phenylphthalide 
• 79419-94-6 3-(1H-imidazol-1-yl)-2,3-diphenylisoindolin-1-one 

Relevant articles and documents

Copper-catalyzed aerobic double functionalization of benzylic C(sp3)-H bonds for the synthesis of 3-hydroxyisoindolinones

A copper-catalyzed aerobic 3-hydroxyisoindolinone synthesis was developed via the benzylic double C(sp3)-H functionalization of 2-alkylbenzamides. In this reaction, molecular oxygen was used as both an oxidant for C(sp3)-H functionalization and an oxygen source. Our method can be extended to diverse benzylic C(sp3)-H bonds and shows excellent functional group tolerance. This journal is

Lithium–Bromide Exchange versus Nucleophilic Addition of Schiff's base: Unprecedented Tandem Cyclisation Pathways

By exploring lithium–bromide exchange reactivity of aromatic Schiff's bases with tert-butyllithium (tBuLi), we have revealed unprecedented competitive intermolecular and intramolecular cascade annulation pathways, leading to valuable compounds, such as iso-indolinones and N-substituted anthracene derivatives. A series of reaction parameters were probed, including solvent, stoichiometry, sterics and organolithium reagent choice, in order to understand the influences that limit such ring-closing pathways. With two viable reactivity options for the organolithium on the imine; namely, nucleophilic addition or lithium–bromide exchange, a surprising competitive nature was observed, where nucleophilic addition dominated, even under cryogenic conditions. Considering the most commonly used solvents for lithium–bromide exchange, tetrahydrofuran (THF) and diethyl ether (Et2O), contrasting reactivity outcomes were revealed with nucleophilic addition promoted in THF, while Et2O yielded almost double the conversion of cyclic products than in THF.

Preparation of 3-Hydroxyindolin-1-ones and o-Acylbenzamides. A Study of Ring-Chain Tautomerism

3-Hydroxyisoindolinones (ring form) as well as their chain tautomers, o-acylbenzamides, were prepared from the reactions of 3-benzalphthalide 1, 3-halophthalides 3, and o-acylbenzoic acids 6 or their esters 7 with amines 2, and those of phthalimides 4 wit