6622-08-8

Basic information

• Product Name: 1-(diphenylmethyl)pyrrolidine
• Synonyms: 1-(Diphenylmethyl)pyrrolidine; pyrrolidine, 1-(diphenylmethyl)-
• CAS NO: 6622-08-8
• Molecular Formula: C₁₇H₁₉N
• Molecular Weight: 237.3395
• Mol File: 6622-08-8.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 325.9°C at 760 mmHg
• Flash Point: 137.1°C
• Density: 1.069g/cm³
• Vapor Pressure: 0.000224mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 1-(diphenylmethyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(diphenylmethyl)pyrrolidine(6622-08-8)
• EPA Substance Registry System: 1-(diphenylmethyl)pyrrolidine(6622-08-8)

Safety Data

• Hazardous Substances Data: 6622-08-8(Hazardous Substances Data)

Usage

General Description

1-(diphenylmethyl)pyrrolidine, also known as D2PM, is a synthetic compound belonging to the class of pyrrolidine derivatives. It is a designer drug with psychoactive properties, acting as a potent and selective serotonin releasing agent. D2PM has been used as a recreational drug in some countries, leading to its regulation and classification as a controlled substance. It is known to produce stimulating and euphoric effects in users, and has been associated with adverse effects such as agitation, anxiety, and cardiovascular complications. Due to its potential for abuse and harm, D2PM is illegal in many jurisdictions and its production, distribution, and possession are strictly regulated.

Upstream product

• 29897-82-3 N-benzylpyrrolidine 
• 591-50-4 iodobenzene 
• 3760-54-1 1-pyrrolidinecarboxaldehyde 
• 100-58-3 phenylmagnesium bromide 
• 123-75-1 pyrrolidine 
• 108-86-1 bromobenzene 
• 100-52-7 benzaldehyde 
• 119-61-9 benzophenone 
• 3389-54-6 n-benzoylpyrrolidine 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 776-74-9 Bromodiphenylmethane 
• 120-94-5 1-Methylpyrrolidine 
• 591-51-5 phenyllithium 
• 694-00-8 pyrrolidine-1-d₁ 

Downstream Products

• 119-61-9 benzophenone 

Relevant articles and documents

Merging Electron Transfer with 1,2-Metalate Rearrangement: Deoxygenative Arylation of Aromatic Amides with Arylboronic Esters

Amides are essentially inert carboxyl derivatives in many types of chemical transformations. In particular, deoxygenative C?C bond formation of amides to synthetically important amines is a long-standing challenge for synthetic chemists due to the inertness of the resonance-stabilized amide C=O bond. Herein, it is disclosed that by merging electron-transfer-induced activation with 1,2-metalate rearrangement, a wide range of aromatic amides react smoothly with arylboron reagents, affording a series of biologically relevant diarylmethylamines as deoxygenative C?C bond cross-coupling products. With its simplicity and versatility, this reaction shows great promise in the synthesis of amines from amides, which may open up new avenues in retrosynthetic planning and find widespread use in academia and industry.

Hydrogen-free reductive amination using iron pentacarbonyl as a reducing agent

We developed solvent-free reductive amination without an external hydrogen source using iron pentacarbonyl as a reducing agent. Neither a catalyst nor any other additives were employed. Various types of substrates are suitable for the reaction, including

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