6623-66-1

Usage

Uses

Used in Medicinal Chemistry:
6-NITRO-3,4-BENZOCOUMARIN is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and biological activities make it a promising candidate for the development of new drugs.
Used in Drug Development:
6-NITRO-3,4-BENZOCOUMARIN is used as a lead compound in drug discovery and development. Its antimicrobial and anticancer properties are being investigated for potential therapeutic applications.
Used in Antimicrobial Applications:
6-NITRO-3,4-BENZOCOUMARIN is used as an antimicrobial agent for its ability to inhibit the growth of various microorganisms, making it a potential candidate for the development of new antibiotics.
Used in Anticancer Applications:
6-NITRO-3,4-BENZOCOUMARIN is used as an anticancer agent for its potential to target and inhibit the growth of cancer cells. Further research is being conducted to explore its mechanism of action and efficacy in treating various types of cancer.
Used in Pharmaceutical Industry:
6-NITRO-3,4-BENZOCOUMARIN is used in the pharmaceutical industry for its potential to contribute to the development of new drugs with improved therapeutic properties and reduced side effects.
Further research into the properties and potential uses of 6-NITRO-3,4-BENZOCOUMARIN is ongoing to fully understand its capabilities and maximize its potential in various applications.

InChI:InChI=1/C22H20BrN3S/c23-21-10-9-16(27-21)15-24-26-13-11-25(12-14-26)22-19-7-3-1-5-17(19)18-6-2-4-8-20(18)22/h1-10,15,22H,11-14H2

Upstream product

• 2005-10-9 6H-benzo[c]chromen-6-one 
• 85-01-8 phenanthrene 
• 947-84-2 2-Biphenylcarboxylic acid 
• 13331-27-6 m-nitrobenzene boronic acid 
• 37174-74-6 3'-nitro-[1,1'-biphenyl]-2-carboxylic acid 
• 83527-96-2 methyl 3’-nitro-[1,1’-biphenyl]-2-carboxylate 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 100-02-7 4-nitro-phenol 
• 65-85-0 benzoic acid 
• 1195761-05-7 ethyl 3'-nitrobiphenyl-2-carboxylate 
• 1829-28-3 ethyl 2-iodobenzoate 
• 132605-35-7 C₁₁H₁₃N₃S 

Downstream Products

• 83527-99-5 2-amino-6H-benzo[c]chromen-6-one 

Relevant academic research and scientific papers

Facile preparation of 3,4-benzocoumarins from 2-arylbenzoic acids with NCS and NAI

– Treatment of 2-arylbenzoic acids with N-chlorosuccinimide (NCS) and NaI at 70 °C under fluorescent lighting condition gave the corresponding 3,4-benzocoumarins in good yields under transition-metal-free condition. It was found that the reactivity of NCS

Cerium photocatalyzed dehydrogenative lactonization of 2-arylbenzoic acids

The first cerium photocatalyzed dehydrogenative lactonization of 2-arylbenzoic acids has been developed. This operationally simple protocol allows rapid access to synthetically useful coumarins on gram scale by employing CeCl3 as a photocatalyst and O2 as a terminal oxidant. Overall, this delivers an economical and environmentally amiable entry to diversely substituted coumarins, important structural motifs in bioactive molecules.

Palladium-Catalyzed Direct Annulation of Benzoic Acids with Phenols to Synthesize Dibenzopyranones

Direct annulation of benzoic acids with phenols via palladium-catalyzed oxidative coupling is reported. Readily available and inexpensive starting materials were used in this novel method to synthesize highly valuable and useful dibenzopyranone scaffolds.

General and practical carboxyl-group-directed remote C-H oxygenation reactions of arenes

Two methods for remote aromatic C-H oxygenation reactions, have been developed. Method1, the Cu-catalyzed oxygenation reaction, is highly efficient for cyclization of electron-neutral and electron-rich biaryl carboxylic acids into 3,4-benzocoumarins. Method2, the K2S2O 8-mediated oxygenation reaction, is more general and practical for cyclization of substrates with electron-donating and -withdrawing groups (see scheme). Copyright

Reactions of gas-phase phenanthrene under simulated atmospheric conditions

Rate constants for the gas-phase reactions of phenanthrene with OH radicals, NO3 radicals, and O3 have been determined at 296 ± 2 K and atmospheric pressure of air. The rate constants obtained (in cm3 molecule- 1 s-1 units) were (1.27 ± 0.23) x 10-11 for the OH radical reaction, (1.2 ± 0.4) x 10-13 for the NO3 radical reaction under atmospheric conditions, and (4.0 ± 1.0) x 10-19 for the O3 reaction. These rate constants indicate that the OH radical and NO3 radical reactions will be the dominant atmospheric loss processes for phenanthrene and that the overall atmospheric lifetime of gas-phase phenanthrene will be ≤1 day. Mutagenicity bioassays and chemical analyses of the products of the NO3 radical reaction and NO(x)-air photooxidation of phenanthrene were also conducted.

S(RN)1C-arylation of phenols by azosulfides: A novel synthesis of dibenzo[b,d]pyran-6-ones

The ortho-arylation of phenols by (2-cyanoaryl)azo t-butyl (or phenyl) sulfides in S(RN)1 conditions, followed by a silica-gel-catalysed lactonisation of the resulting 2-cyano-2'-hydroxybiphenyls, leads to dibenzo[b,d]pyran-6-ones.