6623-93-4

Basic information

• Product Name: 4-(1-METHYL-1-PHENYL-ETHYL)-ANISOLE
• Synonyms: 4-(1-METHYL-1-PHENYL-ETHYL)-ANISOLE;1-Methoxy-4-(2-phenylpropan-2-yl)benzene
• CAS NO: 6623-93-4
• Molecular Formula: C₁₆H₁₈O
• Molecular Weight: 226.31352
• Mol File: 6623-93-4.mol

Chemical Properties

• Boiling Point: 323.5°C at 760 mmHg
• Flash Point: 127.3°C
• Appearance: /
• Density: 0.998g/cm³
• Vapor Pressure: 0.000492mmHg at 25°C
• Refractive Index: 1.539
• CAS DataBase Reference: 4-(1-METHYL-1-PHENYL-ETHYL)-ANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1-METHYL-1-PHENYL-ETHYL)-ANISOLE(6623-93-4)
• EPA Substance Registry System: 4-(1-METHYL-1-PHENYL-ETHYL)-ANISOLE(6623-93-4)

Safety Data

• Hazardous Substances Data: 6623-93-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-(1-METHYL-1-PHENYL-ETHYL)-ANISOLE is used as a therapeutic agent for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is utilized for its ability to increase the activity of certain neurotransmitters in the brain, leading to enhanced focus and attention in individuals with these conditions.
Used in Medical Treatment:
4-(1-METHYL-1-PHENYL-ETHYL)-ANISOLE is used as a medication to manage the symptoms of ADHD and narcolepsy, providing relief to patients by improving cognitive function and reducing excessive sleepiness. Its effectiveness in these areas is attributed to its action on neurotransmitters, which facilitates better attention and alertness.
Used in Neurotransmitter Regulation:
4-(1-METHYL-1-PHENYL-ETHYL)-ANISOLE is used as a neuromodulator to regulate the levels of specific neurotransmitters in the brain. This regulation is crucial for individuals with ADHD and narcolepsy, as it helps in maintaining an appropriate balance of these chemicals, which is essential for cognitive function and alertness.
Used in Patient Monitoring:
Due to its potential for abuse and dependence, 4-(1-METHYL-1-PHENYL-ETHYL)-ANISOLE is used in the context of patient monitoring to ensure that its use is closely supervised by healthcare professionals. This monitoring helps in mitigating the risks associated with its use and ensures that the benefits of the medication are maximized while minimizing potential side effects.

InChI:InChI=1/C16H18O/c1-16(2,13-7-5-4-6-8-13)14-9-11-15(17-3)12-10-14/h4-12H,1-3H3

Upstream product

• 934-53-2 cumenyl chloride 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 599-64-4 p-cumylphenol 
• 77-78-1 dimethyl sulfate 
• 617-94-7 1-methyl-1-phenylethyl alcohol 
• 100-66-3 methoxybenzene 
• 5720-07-0 4-methoxyphenylboronic acid 
• 98-83-9 isopropenylbenzene 
• 74-88-4 methyl iodide 
• 4333-75-9 1-(4-methoxyphenyl)-1-phenylethene 
• 80-15-9 Cumene hydroperoxide 

Downstream Products

• 599-64-4 p-cumylphenol 
• 70757-61-8 [4-(1-methyl-1-phenyl-ethyl)-phenoxy]-acetic acid 

Relevant articles and documents

Ligand-Enabled Nickel-Catalyzed Redox-Relay Migratory Hydroarylation of Alkenes with Arylborons

A redox-relay migratory hydroarylation of isomeric mixtures of olefins with arylboronic acids catalyzed by nickel complexes bearing diamine ligands is described. A range of structurally diverse 1,1-diarylalkanes, including those containing a 1,1-diarylated quaternary carbon, were obtained in excellent yields and with high regioselectivity. Preliminary experimental evidence supports the proposed non-dissociated chainwalking of aryl-nickel(II)-hydride species along the alkyl chain of alkenes before selective reductive elimination at a benzylic position. A catalyst loading as low as 0.5 mol % proved to be sufficient in large-scale synthesis while retaining high reactivity, highlighting the practical value of this transformation.

A transition metal complex compound, and the compound of the catalyst and a catalyst for large amt. pentavelent carried out in the presence of an olefin multimer manufacturing method

PROBLEM TO BE SOLVED: To provide a transition metal complex compound, an olefin multimerization catalyst having excellent activity and containing the same and a method for producing an olefin multimer carried out in the presence of the catalyst.SOLUTION: This transition metal complex compound is one having a phenoxyimine ligand and this olefin multimerization catalyst contains following component (A) and component (B). (A) is the transition metal compound and (B) is a compound selected from the group consisting of an organic metal compound (B-1), an organic aluminumoxy compound (B-2) and a compound (B-3) forming an ion pair by reacting with the transition metal compound (A).

A transition metal complex compound, and the compound of the catalyst and a catalyst for large amt. pentavelent carried out in the presence of an olefin multimer manufacturing method

PROBLEM TO BE SOLVED: To provide a transition metal complex compound, to provide an olefin polymerizing catalyst, containing the compound, and having excellent activity, and to provide a method for producing the olefin polymer which is carried out in the presence of the catalyst.SOLUTION: There is provided the transition metal complex compound of compound 3, e.g. of chemical formula; and the olefin polymerizing catalyst including following components (A) and (B): (A) the transition metal compound; and (B) at least one compound selected from the group consisting of (B-1) an organometallic compound, (B-2) an organoaluminumoxy compound, and (B-3) a compound reactive with the transition metal compound (A), and forming an ion pair.

Gold-catalyzed hydroarylation of alkenes with dialkylanilines

Anti-Bredt di(amino)carbene supported gold(I) chloride complexes are readily prepared in two steps from the corresponding isocyanide complexes. In the presence of KB(C6F5)4as chloride scavenger, they promote the unprecedented hydroarylation reaction of alkenes with N,N-dialkylanilines with high para-selectivity. The latter are challenging arenes for Friedel-Craft reactions, due to their high basicity.

Cationic Iron(III) porphyrin catalyzed dehydrative friedel-crafts reaction of alcohols with arenes

Alcohols react with arenes in the presence of cationic iron(III) porphyrin catalyst. The reaction involves the formation of the C-C bond via dehydration, which is formal Lewis acid catalyzed Friedel-Crafts reaction. Georg Thieme Verlag Stuttgart, New York.

H-β-zeolite-catalysed hydroarylation of styrenes

The hydroarylation of styrenes with various arene(heteroarene) compounds using H-β-zeolite as a green and recyclable heterogeneous catalyst under mild reaction conditions has been developed. The catalyst showed versatility and high selectivity (up to 100a€‰%) of desired 1,1-diarylalkanes in cyclohexane as solvent under the conditions studied. The catalyst could be reactivated by simple treatment with mineral acid at room temperature for better catalytic activity. Hydroarylation of styrenes with variousarene(heteroarene) compounds using H-β-zeolite as a green, heterogeneous and reusable catalyst under mild conditions is reported.

Calcium-catalyzed hydroarylation of alkenes at room temperature

Calcium-catalyst gaining ground: A variety of electron-poor electron-rich and trisubstituted styrene derivatives were reacted to give the desired diarylalkanes within less than an hour at room temperature in the presence of 2.5 mol % of Ca(NTf2)2/Bu4NPF6 (see scheme). Additionally the highly reactive calcium catalyst was successfully applied for the hydroarylation of dienes and even trisubstituted olefins.

Efficient and general continuous-flow hydroarylation and hydroalkylation of styrenes

A simple and efficient continuous-flow hydroarylation of arenes and heteroarenes using various styrenes in conjunction with a heterogeneous catalyst has been developed. Additionally, this method has been successfully extended to the hydroalkylation of styrenes by employing 1,3-dicarbonyl compounds as the nucleophile. Multigram quantities of diarylmethanes have been prepared using this new flow method. Copyright

Versatile friedel-crafts-type alkylation of benzene derivatives using a molybdenum complex/ortho-chloranil catalytic system

A variety of molybdenum complexes catalyze Friedel-Crafts-type alkylation reactions of benzene derivatives with alkenes and alcohols in the presence of an organic oxidant, o-chloranil. The utilization of [Mo(CO)6] and two equivalents of o-chloranil catalytically furnished the hydroarylation product of norbornene with p-xylene at 80°C, whereas [Cr(CO)6] and [W(CO)6] failed to catalyze the same reaction, thus indicating the importance of the molybdenum source. The best results were obtained when a molybdenum(II) complex [CpMoCl(CO)3] (Cp = cyclopentadienyl) was used as a precatalyst. The hydroarylation reactions also took place with styrenes, cyclohexenes, and 1 -hexene as olefin substrates. The electrophilic-substitution mechanism was proposed on the basis of the ortho/para selectivities and the Markovnikov selectivities observed for the hydroarylation products. Our hypothesis was further corroborated by the fact that in the presence of the [CpMoCl(CO)3]/o-chloranil catalytic system, secondary, benzylic, or allylic alcohols participated in the alkylation of benzenes with similar selectivities.

A novel InCl3/SiO2-catalyzed hydroarylation of arenes with styrenes under solvent-free conditions

A novel InCl3/SiO2-catalyzed hydroarylation of various styrenes with arenes has been developed. The reaction can be carried out under solvent-free conditions to afford a series of 1,1-diarylalkanes in high yields and with good regioselectivities. The catalyst can be reused six times without obvious loss of catalytic activity. Georg Thieme Verlag Stuttgart.