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N-Methyl-N-(trifluoromethylthio)aniline is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

66476-44-6

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66476-44-6 Usage

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N-Methyl-N-(trifluoromethylthio)aniline is a useful research chemical.

Check Digit Verification of cas no

The CAS Registry Mumber 66476-44-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,4,7 and 6 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 66476-44:
(7*6)+(6*6)+(5*4)+(4*7)+(3*6)+(2*4)+(1*4)=156
156 % 10 = 6
So 66476-44-6 is a valid CAS Registry Number.

66476-44-6 Well-known Company Product Price

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  • TCI America

  • (M2595)  N-Methyl-N-(trifluoromethylthio)aniline  >98.0%(GC)

  • 66476-44-6

  • 200mg

  • 790.00CNY

  • Detail
  • TCI America

  • (M2595)  N-Methyl-N-(trifluoromethylthio)aniline  >98.0%(GC)

  • 66476-44-6

  • 1g

  • 2,750.00CNY

  • Detail

66476-44-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N-methyl-N-phenyl-S-(trifluoromethyl)thiohydroxylamine

1.2 Other means of identification

Product number -
Other names trifluoromethanesulfenamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:66476-44-6 SDS

66476-44-6Relevant academic research and scientific papers

Palladium-Catalyzed Trifluoromethylthiolation of Chelation-Assisted C–H Bonds

Kesavan, Arunachalam,Chaitanya, Manthena,Anbarasan, Pazhamalai

supporting information, p. 3276 - 3279 (2018/07/13)

An efficient palladium-catalyzed trifluoromethylthiolation of chelation-assisted C–H bonds has been accomplished by employing a readily accessible trifluoromethylthiolating reagent. The reaction tolerates various directing groups and functional groups and allows the access to diverse trifluoromethylthiolated arenes in good yield. A plausible mechanism was proposed based on preliminary mechanistic investigations.

For the production of sulfur-hydrogen reagent, synthetic method and its application

-

Paragraph 0106-0108, (2017/09/26)

The invention discloses a trifluoromethylthio reagent as well as a synthetic method and application thereof and provides a compound I and a preparation method of the compound I. The preparation method comprises the step: reacting a compound 1a with trifluoromethylthio silver, so as to obtain the compound 1, wherein the reaction is as shown in the specification. The invention further provides application of the compound 1 as the trifluoromethylthio reagent. The compound 1 can react with amine compounds, thiol or phenolic compounds to generate the compound containing trifluoromethylthio. The trifluoromethylthio reagent 1 has the beneficial effects of high efficiency, conversion rate and yield, mild reaction conditions, low production cost and wide applicable range and is applicable to industrial production.

Multigram Scale Syntheses of First and Second Generation of Trifluoromethanesulfenamide Reagents

Glenadel, Quentin,Alazet, Sébastien,Baert, Fran?ois,Billard, Thierry

, p. 960 - 964 (2016/06/13)

Trifluoromethanesulfenamide reagents constitute a family of very efficient reagents to trifluoromethylthiolate various molecules. Optimized syntheses have been developed to easily obtain, in a reproducible manner, large quantities of these reagents, with good overall yields. Up to 84 g have already been obtained, at a reasonable cost.

2-Diazo-1-phenyl-2-((trifluoromethyl)sulfonyl)ethan-1-one: Another Utility for Electrophilic Trifluoromethylthiolation Reactions

Huang, Zhongyan,Okuyama, Kenta,Wang, Chen,Tokunaga, Etsuko,Li, Xiaorui,Shibata, Norio

, p. 188 - 191 (2016/07/11)

2-Diazo-1-phenyl-2-((trifluoromethyl)sulfonyl)ethan-1-one (diazo-triflone) (2) is not only a building block but also a reagent. In this study, diazo-triflone, which was originally used for the synthesis of β-lactam triflones as a trifluoromethanesulfonyl

N-Trifluoromethylthio-dibenzenesulfonimide: A Shelf-Stable, Broadly Applicable Electrophilic Trifluoromethylthiolating Reagent

Zhang, Panpan,Li, Man,Xue, Xiao-Song,Xu, Chunfa,Zhao, Qunchao,Liu, Yafei,Wang, Haoyang,Guo, Yinlong,Lu, Long,Shen, Qilong

, p. 7486 - 7509 (2016/09/09)

The super electrophilicity of a shelf-stable, easily prepared trifluoromethylthiolating reagent N-trifluoromethylthio-dibenzenesulfonimide 7 was demonstrated. Consistent with the theoretical prediction, 7 exhibits reactivity remarkably higher than that of other known electrophilic trifluoromethylthiolating reagents. In the absence of any additive, 7 reacted with a wide range of electron-rich arenes and activated heteroarenes under mild conditions. Likewise, reactions of 7 with styrene derivatives can be fine-tuned by simply changing the reaction solvents to generate trifluoromethylthiolated styrenes or oxo-trifluoromethylthio or amino-trifluoromethylthio difunctionalized compounds in high yields.

Selective and scalable synthesis of trifluoromethanesulfenamides and fluorinated unsymmetrical disulfides using a shelf-stable electrophilic SCF3 reagent

Pluta, Roman,Rueping, Magnus

supporting information, p. 17315 - 17318 (2015/02/19)

The chemoselective trifluoromethylthiolation of nitrogen nucleophiles and thiols using N-(trifluorome-thylthio)phthalimide under mild, metal-free conditions is described. A series of trifluoromethanesulfenamides and unsymmetrical disulfides is prepared from the corresponding aliphatic and aromatic amines and thiols in good yields. The reactions are operationally simple and tolerate a wide variety of functional groups. Trifluoromethanesulfenamides and disulfides belong to interesting classes of organic molecules which possess remarkable properties for medicinal and agrochemical applications.

N-trifluoromethylthiosaccharin: An easily accessible, shelf-stable, broadly applicable trifluoromethylthiolating reagent

Xu, Chunfa,Ma, Bingqing,Shen, Qilong

supporting information, p. 9316 - 9320,5 (2014/10/15)

A new, electrophilic trifluoromethylthiolating reagent, N-trifluoromethylthiosaccharin, was developed and can be synthesized in two steps from saccharin within 30minutes. N-trifluoromethylthiosaccharin is a powerful trifluoromethylthiolating reagent and allows the trifluoromethylthiolation of a variety of nucleophiles such as alcohols, amines, thiols, electron-rich arenes, aldehydes, ketones, acyclic β-ketoesters, and alkynes under mild reaction conditions. 'Sacch'ed out: A new, electrophilic trifluoromethylthiolating reagent, N-trifluoromethylthiosaccharin (1) can be synthesized in two steps from saccharin within 30minutes. The reagent 1 allows the trifluoromethylthiolation of a variety of nucleophiles such as alcohols, amines, thiols, electron-rich arenes, aldehydes, ketones, acyclic β-ketoesters, and alkynes under mild reaction conditions.

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