78914-94-0

Basic information

• Product Name: 1-METHOXY-4-TRIFLUOROMETHYLSULFANYL-BENZENE
• Synonyms: 4-(THIOTRIFLUOROMETHYL)ANISOLE;1-METHOXY-4-TRIFLUOROMETHYLSULFANYL-BENZENE;4-Methoxyphenyl trifluoromethyl sulphide;4-methoxyphenyl trifluoromethylsulfide
• CAS NO: 78914-94-0
• Molecular Formula: C₈H₇F₃OS
• Molecular Weight: 208.2
• Mol File: 78914-94-0.mol
• Article Data: 50

Chemical Properties

• Boiling Point: 162.7 °C at 760 mmHg
• Flash Point: 52.2 °C
• Appearance: /
• Density: 1.3 g/cm³
• CAS DataBase Reference: 1-METHOXY-4-TRIFLUOROMETHYLSULFANYL-BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHOXY-4-TRIFLUOROMETHYLSULFANYL-BENZENE(78914-94-0)
• EPA Substance Registry System: 1-METHOXY-4-TRIFLUOROMETHYLSULFANYL-BENZENE(78914-94-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 78914-94-0(Hazardous Substances Data)

Usage

General Description

1-Methoxy-4-trifluoromethylsulfanyl-benzene, also known as TFMOMe, is a chemical compound with the molecular formula C8H7F3OS. It is a colorless liquid at room temperature and is primarily used as an intermediate in the production of pharmaceuticals and agrochemicals. TFMOMe is also used as a building block in organic synthesis, particularly in the field of medicinal chemistry. It is considered to be a hazardous substance and precautions should be taken when handling and using it. TFMOMe has a strong odor and is flammable, making it important for it to be stored and handled with care.

Upstream product

• 421-17-0 Trifluoromethylsulfenyl chloride 
• 100-66-3 methoxybenzene 
• 696-63-9 4-Methoxybenzenethiol 
• 2926-29-6 Langlois reagent 
• 372-64-5 Bis(trifluoromethyl)disulfid 
• 104-94-9 4-methoxy-aniline 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 719-98-2 N-((trifluoromethyl)thio)isoindoline-1,3-dione 
• 5720-07-0 4-methoxyphenylboronic acid 
• 696-62-8 para-iodoanisole 
• 1413732-47-4 (2,2'-bipyride-kN₁,kN₁')(1,1,1-trifluoromethanethiolato-kS)-copper 
• 66476-44-6 N-methyl-N-phenyl-S-(trifluoromethyl)thiohydroxylamine 
• 699-19-4 4-methoxyphenylmagnesium chloride 

Downstream Products

• 32916-20-4 1-methoxy-4-((trifluoromethyl)sulfinyl)benzene 
• 613-37-6 4-methoxylbiphenyl 
• 75070-85-8 rhodium hydrido (PEt₃)3 complex 
• 194222-69-0 (2,6-Dinitro-4-trifluoromethanesulfonyl-phenyl)-trifluoromethanesulfonyl-acetic acid ethyl ester 
• 19822-34-5 2,6-dinitro-4-trifluoromethylsulfonylchlorobenzene 
• 19822-29-8 2,6-dinitro-4-((trifluoromethyl)sulfonyl)anisole 
• 15183-74-1 1-methoxy-4-((trifluoromethyl)sulfonyl)benzene 

Relevant articles and documents

Electrochemical Trifluoromethylation of Thiophenols with Sodium Trifluoromethanesulfinate

We developed an electrochemical trifluoromethylation of thiophenols without the use of metal catalysts and oxidants. This reaction features mild reaction conditions, readily available substrate, as well as moderate to good yields. In addition, this protocol can be easily scaled up with moderate efficiency.

Trifluoromethyl Sulfoxides: Reagents for Metal-Free C?H Trifluoromethylthiolation

Trifluoromethyl sulfoxides are a new class of trifluoromethylthiolating reagent. The sulfoxides engage in metal-free C?H trifluoromethylthiolation with a range of (hetero)arenes. The method is also applicable to the functionalization of important compound classes, such as ligand derivatives and polyaromatics, and in the late-stage trifluoromethylthiolation of medicines and agrochemicals. The isolation and characterization of a sulfonium salt intermediate supports an interrupted Pummerer reaction mechanism.

A process for converting substituted phenyl diazonium salts into [(trifluoromethyl)thio]benzene

The invention discloses a synthetic method of [(trifluoromethyl)thio]benzene compounds, particularly a method for converting substituted phenyl diazonium salts into [(trifluoromethyl)thio]benzene. Themethod comprises the following steps: under white light