6736-97-6

Upstream product

• 10416-59-8 N,O-bis-(trimethylsilyl)-acetamide 
• 50-99-7 D-glucose 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 1176306-07-2 1-O-3,4-(dihydroxyphenyl)ethyl-β-D-apiofuranosyl-(1->2)-β-D-xylopyranosyl-(1->3)-4-O-caffeoyl-β-D-glucopyranoside 
• 18156-74-6 1-(Trimethylsilyl)imidazole 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 34272-03-2 propargyl β-D-glucopyranoside 
• 151168-60-4 prop-2-ynyl-α-D-glucopyranoside 

Relevant academic research and scientific papers

Further 2R-Benzylmalate derivatives from the undergrounds parts of Arundina graminifolia (Orchidaceae)

Nine new glucosyloxybenzyl 2R-benzylmalate derivatives, named arundinosides R–Z (1-9) were isolated from the underground parts of Arundina graminifolia. The structures of the new compounds were elucidated by in-depth spectroscopic data analysis including

Identification of potential inflammatory inhibitors from Aster tataricus

Aster tataricus L.f. is a traditional Eastern Asian herbal medicine used for the relief of cough-related illnesses. In this study, 32 known compounds and two novel monoterpene glycosides were isolated from the roots of A. tataricus. With the aid of reported data, elucidation of the root-extract components was carried out using a multitude of spectroscopic techniques. All isolates were investigated for their ability to inhibit nitric oxide (NO) secretion in lipopolysaccharide-activated RAW264.7 cells. Compound 7 remarkably suppressed NO production with an IC50 value of 8.5 μM. In addition, compound 7 exhibited significant inhibitory activity against the production of inflammatory cytokines (prostaglandin E2, interleukin-6, and interleukin-1 beta) and the expression of inflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2) via inhibition of nuclear factor-kappa B activation. Moreover, compound 7 effectively prevented the downstream activation of the mitogen-activated protein kinase signaling pathway by inhibiting phosphorylation of c-Jun N-terminal kinases, extracellular signal-regulated kinases, and p38. These results outline compound 7 as a potential inhibitor for the broad treatment of inflammatory diseases, such as atopic dermatitis, asthma, and various allergies.

Novel quercetin glucosides from Helminthostachys zeylanica root and acceleratory activity of melanin biosynthesis

Two novel quercetin glucosides, namely 4′-O-β-d-glucopyranosyl- quercetin-3-O-β-d-glucopyranosyl-(1→4)-β-d-glucopyranoside (compound 1) and 4′-O-β-d-glucopyranosyl-(1→2)-β-d- glucopyranosyl-quercetin-3-O-β-d-glucopyranosyl-(1→4) -β-d-glucopyranoside (compound 2), were isolated from Helminthostachys zeylanica root 50 % EtOH extract. Structural analysis of isolated compounds was achieved mainly by 600 MHz and 800 MHz NMR, UPLC-TOFMS and GC-MS. Of the two quercetin glucosides, compound 1 showed a high melanogenic acceleratory effect, 2.7 times higher than control, at 10 μM concentration in murine B16 melanoma cells, with no cytotoxic effect.

Real-time evaluation of binding mechanisms in multivalent interactions: A surface plasmon resonance kinetic approach

Multivalency is a key, ubiquitous phenomenon in nature characterized by a complex combination of binding mechanisms, with special relevance in carbohydrate-lectin recognition. Herein we introduce an original surface plasmon resonance kinetic approach to analyze multivalent interactions that has been validated with dendrimers as monodisperse multivalent analytes binding to lectin clusters. The method, based on the analysis of early association and late dissociation phases of the sensorgrams provides robust information of the glycoconjugate binding efficiency and real-time structural data of the binding events under the complex scenario of the glyco-cluster effect. Notably, it reveals the dynamic nature of the interaction and offers experimental evidence on the contribution of binding mechanisms.

Triterpenoid saponins from Gynostemma pentaphyllum

Four new dammarane-type triterpene saponins, 1-4, were isolated from the aerial parts of Gynostemma pentaphyllum (Thunb.) Makino. Their structural elucidations were accomplished mainly on the basis of spectroscopic methods, such as IR, HR-TOF-MS, and NMR. Compounds 1-4 showed moderate cytotoxic activities against cancer cell lines HL-60, Colon205, and Du145 in vitro.

Phenylethanoid glycosides from Lantana fucata with in vitro anti-inflammatory activity

A phytochemical analysis of Lantana fucata dried leaves led to the isolation of three new phenylethanoid glycosides, fucatosides A-C, along with parvifloroside A and six known methoxyflavones. Their structures were established by NMR and ESIMS experiments

A new neo-clerodane diterpene and its glycoside from Aster souliei

Two new neo-clerodane type diterpenoids namely, soulidiol and soulidioside have been isolated from Aster souliei and their structures have been elucidated to be 18, 19-dihydroxy-5α, 10β-neocleroda-3, 13(14)-dien-16, 15-butenolide 1 and its 18-O-D-glucopyranosyl, 19-hydroxy-5α, 10β, neo-cleroda-3, 13(14)-dien-16, 15-butenolide 2.

Tannins and Related Compounds. LXIII. Isolation and Characterization of Mongolicains A and B, novel Tannins from Quercus and Castanopsis Species

Continuing chemical examinations on tannins have led to the isolation of two new tannins, mongolicains A (3) and B (4), from five Quercus and one Castanopsis species.The structures of 3 and 4 have been characterized on the basis of chemical and spectroscopic data as novel flavanoellagitannins, in which hydrolyzable tannin and flavan-3-ol moieties are connected through a carbon-carbon linkage.Their structural features suggest that 3 and 4 are biosynthetically formed by oxidation of accompanying acutissimins A (1) and B (2).Keywords - Quercus sp.; Castanopsis sp.; Fagaceae; mongolicain A; mongolicain B; flavanoellagitannin; C-glycosidic tannin; flavan-3-ol; oxidative metabolite; 1H-13C long-range shift correlation spectrum