6794-69-0

Usage

Uses

Used in Organic Synthesis:
4-Phenyl-1,3-dihydro-imidazol-2-one is used as a building block in organic synthesis for the creation of various complex organic molecules. Its unique structure allows for versatile chemical reactions, making it a valuable component in the synthesis of a wide range of compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-Phenyl-1,3-dihydro-imidazol-2-one serves as a starting material for the synthesis of bioactive compounds and pharmaceuticals. Its structural features contribute to the development of new drugs with potential therapeutic applications.
Used in Neuropharmacology:
4-Phenyl-1,3-dihydro-imidazol-2-one is used as a GABA receptor agonist in neuropharmacological research. Its interaction with GABA receptors suggests potential applications in the treatment of neurological disorders, including anxiety and other conditions related to the central nervous system.
Used in Neuroprotective Studies:
4-Phenyl-1,3-dihydro-imidazol-2-one has been investigated for its neuroprotective effects, indicating potential use in the development of therapies aimed at protecting neurons from damage or degeneration, which could be beneficial in the treatment of neurodegenerative diseases.
Used in the Treatment of Anxiety and Neurological Disorders:
4-Phenyl-1,3-dihydro-imidazol-2-one has been studied for its potential application in the treatment of anxiety and other neurological disorders due to its interaction with GABA receptors and its neuroprotective properties, offering a promising avenue for therapeutic intervention in these conditions.

Upstream product

• 89-24-7 5-phenylimidazolidine-2,4-dione 
• 88419-01-6 3-(2-oxo-2-phenylethyl)thiazolidine-2,4-dione 
• 100-97-0 hexamethylenetetramine 
• 70-11-1 α-bromoacetophenone 
• 100-42-5 styrene 
• 1154744-44-1 C₁₇H₂₄N₂O 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 57-13-6 urea 
• 88419-13-0 2,4-dioxo-3-thiazolidinylmethyl phenyl ketone azine 
• 5918-93-4 1,3-dihydroimidazolone 
• 591-50-4 iodobenzene 
• 97567-79-8 2-amino-4-t-butyloxazole 
• 5468-37-1 2-aminoacetophenone hydrochloride 
• 593-75-9 methyl isocyanate 

Downstream Products

• 27129-49-3 4-phenylimidazolidin-2-one 
• 1078715-71-5 5-phenyl-4-phenylazo-3-imidazolin-2-one 
• 1026342-77-7 3-(3-Ethoxycarbonyl-propyl)-2-oxo-4-phenyl-2,3-dihydro-imidazole-1-carboxylic acid ethyl ester 
• 161468-68-4 2-Oxo-4-phenyl-1H-imidazole-1,3(2H)-dicarboxylic acid 1-ethyl-3-(1,1-dimethylethyl) ester 
• 1026573-85-2 3-Benzyl-2-oxo-5-phenyl-2,3-dihydro-imidazole-1-carboxylic acid tert-butyl ester 
• 1025919-95-2 3-Benzyl-2-oxo-4-phenyl-2,3-dihydro-imidazole-1-carboxylic acid ethyl ester 
• 1027302-96-0 3-Methoxycarbonylmethyl-2-oxo-4-phenyl-2,3-dihydro-imidazole-1-carboxylic acid ethyl ester 
• 1026743-92-9 2-Oxo-4-phenyl-3-propyl-2,3-dihydro-imidazole-1-carboxylic acid ethyl ester 
• 161468-69-5 2,3-Dihydro-2-oxo-5-phenyl-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester 
• 83229-99-6 1-benzyl-5-phenyl-4-imidazolin-2-one 
• 93782-04-8 1,3-Dihydro-4-phenyl-1-(phenylmethyl)-2H-imidazol-2-one 
• 84039-96-3 1-benzoyl-3-formylurea 
• 161468-67-3 Ethyl 2,3-dihydro-2-oxo-4-phenyl-1H-imidazole-1-carboxylate 

Relevant academic research and scientific papers

CYCLIC N-CARBOXAMIDE COMPOUNDS USEFUL AS HERBICIDES

Disclosed are compounds of Formula (1), including all stereoisomers, N-oxides, and salts thereof, (Formula (1)) wherein G, J, Q1, R4, Y2, Q2, R5 and Y1 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (1) and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.

CuI-catalyzed sequential diamination and dehydrogenation of terminal olefins: A facile approach to imidazolinones

Diamination of olefins presents a powerful strategy to access vicinal diamines. During the last decade, metal-catalyzed diamination of olefins has received considerable attention. This study describes an efficient sequential diamination and dehydrogenatio

Phenacyl esters of acetic acid derivatives and their application for the synthesis of 2-oxo-4-phenyl-5-(phenylhydrazono)-2,5-dihydro-furan-3-derivatives

(Chemical Equation Presented) Coupling of various substituted phenacyl acetates 1 and diazonium salts 3 was studied. If the phenacyl acetates were substituted by an electronaceptor group such as CN or COOEt 3-substituted phenyl-5-(phenyl-hydrazono)-5H-fur

Palladium-catalyzed direct functionalization of imidazolinone: Synthesis of dibromophakellstatin

The direct C-H functionalization of imidazolinone is achieved with Pd(OAc)2/NaOAc in DMSO. Dibromophakellstatin can be synthesized in five steps with 40% overall yield using this new C-H activation method. Copyright

ARYLSULFONYLIMIDAZOLONE DERIVATIVES AS AN ANTITUMOR AGENT

The present invention relates to a novel arylsulfonylimidazolone derivative represented by the following formula (I) which shows a superior antineoplastic activity in contrast to the known sulfonylurea antitumor agents as well as little side effect: and its pharmaceutically acceptable salt and stereoisomer, in which +E,uns - -+EE , R1, and R2 are as defined in the specification.

Synthesis and anticonvulsant activity of some new 4-aryl-4-imidazoline-2-one derivatives

In this study, some new 4-aryl-4-imidazoline-2-one deriratives have been prepared by the reaction of potassium cyanate with some aminoethanone hydrochlorides. The structure of these compounds have been confirmed by UV, IR, 1H-NMR and elementary analysis. Their anticonvulsant activities were determined by maximal electroshock (MTS) and subcutaneous metrazol (scMet) tests according to the ADD (Antiepileptic Drug Development) programme Phase I. Neurotoxicity of the compounds was evaluated by rotarod test. While 2 of the compounds showed protection against ScMet induced seizures at 30 and 300 mg/kg dose levels, 3 of the compounds showed neurotoxicity.

SYNTHESIS OF 4-IMIDAZOLIN-2-ONES

The reaction of α-bromoketones with CO(NH2)2 and AcONH4 in aqueous acetic acid gave substituted 4-imidazolin-2-ones.

Formation of Thioamide Derivatives from Reactions of Isothiocyanates with Oxazol-2-amines

4-Substituted oxazol-2-amines react with isothiocyanates to give products having a thioamide function at C5.The reaction is considered to be an electrophilic process in competition with the usual reaction of the amino group with the isothiocyanate.The nature of the isothiocyanate and the type of substituent at C4 affect the amount of the thioamide product formed.Some chemical properties of the thioamides are also investigated.

RECYCLIZATION REACTIONS. RECYCLIZATIONS OF 3-ACYLMETHYL-2,4-THIAZOLIDINEDIONES BY THE ACTION OF NUCLEOPHILES

Four directions were established and investigated in the recyclization of 3-acylmethyl-2,4-thiazolidinediones with the participation of the side chain at the cyclic nitrogen atom and the formation of substituted 2-imidazolones or 2-oxazolones (under the influence of ammonia or hydroxides respectively), 2,5-diarylpyrazines (under the influence of methylamine), 6-monosubstituted or 2,6-disubstituted 4,5-dihydro-1,2,4-triazin-3-ones, and 5-substituted 1-amino-2-imidazolones (under the influence of hydrazine and phenylhydrazine).The directions of recyclization with hydrazines are determined by the stereochemical configuration of the intermediate hydrazones; the E-hydrazones of 3-acylmethyl-2,4-thiazolidenediones are converted into 4,5-dihydro-1,2,4-triazin-3-ones, while the Z izomers are converted into 1-amino-2-imidazolones.