68301-11-1Relevant articles and documents
Synthesis of multi-substituted 1,2,4-triazoles utilising the ambiphilic reactivity of hydrazones
Matsuzaki, Haruo,Takeda, Norihiko,Yasui, Motohiro,Okazaki, Mayuko,Suzuki, Seishin,Ueda, Masafumi
supporting information, p. 12187 - 12190 (2021/11/30)
The synthesis of N-alkyl-1H-1,2,4-triazoles from N,N-dialkylhydrazones and nitriles via formal [3+2] cycloaddition including the C-chlorination/nucleophilic addition/cyclisation/dealkylation sequence was developed. This sequential reaction utilising the in situ generation of hydrazonoyl chloride based on the ambiphilic reactivity of hydrazones afforded a variety of multi-substituted N-alkyl-triazoles in high yields. The synthetic utility of multi-substituted triazoles was also demonstrated by further transformations.
Regiospecific syntheses of the monomethylated 3-phenyldihydro-1,2,4-triazin-6(1H)-ones
Collins, David J.,Hughes, Timothy C.,Johnson, Wynona M.
, p. 463 - 468 (2007/10/03)
Unambiguous syntheses of four unreported monomethylated derivatives of 3-phenyldiliydro-1,2,4-triazin-6(1H)-ones, namely, the 1-methyl (2), 2-methyl (3), 4-methyl (4) and the imidic O-methyl derivative (5), are described. Regioselectivity was achieved for
N-Methyl-N-(phenylsulfonyl)benzohydrazonoyl Chloride as a Potential Intermediate for Nitrogen-heterocycles. Preparation of 1-Methyl-3-phenyl-1H-1,2,4-triazoles and -pyrazoles
Ito, Suketaka,Tanaka, Yumo,Kakehi, Akikazu,Fukuyama, Toshihiko,Osawa, Nobuo,Sayo, Noboru
, p. 545 - 548 (2007/10/02)
3,5-Disubstituted 1-methyl-1H-1,2,4-triazoles and -pyrazoles were obtained in good to moderate yields by the reaction of N-methyl-N-(phenylsulfonyl)benzohydrazonoyl chloride with nitriles and with acetylenes in the presence of aluminum chloride.The triazo
