68388-09-0

Basic information

• Product Name: 2,5-Pyrrolidinedione, 1-[(4-chlorobenzoyl)oxy]-
• CAS NO: 68388-09-0
• Molecular Formula: C11H8ClNO4
• Molecular Weight: 253.642
• Mol File: 68388-09-0.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: 2,5-Pyrrolidinedione, 1-[(4-chlorobenzoyl)oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Pyrrolidinedione, 1-[(4-chlorobenzoyl)oxy]-(68388-09-0)
• EPA Substance Registry System: 2,5-Pyrrolidinedione, 1-[(4-chlorobenzoyl)oxy]-(68388-09-0)

Safety Data

• Hazardous Substances Data: 68388-09-0(Hazardous Substances Data)

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 74-11-3 para-chlorobenzoic acid 
• 637-87-6 1-Chloro-4-iodobenzene 
• 201230-82-2 carbon monoxide 
• 873-76-7 para-Chlorobenzyl alcohol 
• 104-88-1 4-chlorobenzaldehyde 
• 17592-54-0 2,5-dioxopyrrolidin-1-yl formate 
• 74124-79-1 di(succinimido) carbonate 

Downstream Products

• 142947-63-5 N,N'-bis<6-(4-chlorobenzamido)hexanoyl>cystamine 
• 913816-02-1 9-(4-(4'-chlorobenzoylamino)hexyl)-9-azabicyclo[3.3.1]nonan-3α-yl 2-methoxy-5-methylphenylcarbamate 
• 95597-10-7 2-(4-chlorobenzoylamino)-3-(1-methyloxindol-3-yl)propionic acid 
• 7461-34-9 N-benzyl-p-chlorobenzamide 
• 14062-80-7 N,N-dimethyl-4-chlorobenzamide 
• 6833-15-4 4-chlorobenzanilide 
• 19202-05-2 N-(4-chlorobenzoyl)pyrrolidine 
• 71320-77-9 moclobemide 
• 1613-88-3 4-chloro-N-hydroxybenzamide 
• 19202-04-1 N-(4-chlorobenzoyl)morpholine 
• 97783-51-2 N,N'-bis<6-<(4-chlorobenzyl)amino>hex-1-yl>cystamine 

Relevant articles and documents

Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme

Indoleamine 2,3-dioxygenase 1 (IDO1), a heme-containing enzyme that mediates the rate-limiting step in the metabolism of l-tryptophan to kynurenine, has been widely explored as a potential immunotherapeutic target in oncology. We developed a class of inhi

N -Heterocyclic carbene (NHC) catalyzed amidation of aldehydes with amines via the tandem N -hydroxysuccinimide ester formation

A facile method for the amidation of aldehydes by a cascade approach was developed. This methodology, reported for the first time, uses a N-heterocyclic carbene (NHC) as the catalyst, and N-hydroxysuccinimide (NHS) mediated synthesis of amides utilising TBHP as the oxidant. Various substituted aldehydes reacted smoothly with NHS giving the corresponding active esters in moderate to good yields, which facilely converted into amides in one pot. In addition, the drug moclobemide was synthesized to represent the practical utility of the developed methodology. This journal is

COMPOUNDS USEFUL AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN DIOXYGENASE

Compounds of formula (VII), which are useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase, are provided. Also provided are pharmaceutical compositions, kits comprising said compounds, and methods and uses pertaining to said compounds.