6850-63-1Relevant articles and documents
SULPHONYL UREA DERIVATIVES AS NLRP3 INFLAMMASOME MODULATORS
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Paragraph 01072, (2019/07/13)
The present disclosure relates to compounds of Formula (I): (I) and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.
N-substituted diphosphinoamines: Toward rational ligand design for the efficient tetramerization of ethylene
Kuhlmann, Sven,Blann, Kevin,Bollmann, Annette,Dixon, John T.,Killian, Esna,Maumela, Munaka C.,Maumela, Hulisani,Morgan, David H.,Pretorius, Marie,Taccardi, Nicola,Wasserscheid, Peter
, p. 279 - 284 (2007/10/03)
Bis(diphenylphosphino)amine (PNP) ligands with different alkyl and cycloalkyl substituents attached to the N atom of the ligand backbone were synthesised and tested together with chromium as ethylene tetramerization catalysts. On activation with a methylaluminoxane-based activator, the catalysts displayed good activity and selectivity toward 1-octene and 1-hexene, with the best ligand systems containing cyclopentyl or cyclohexyl moieties. In addition, it was established that substitution at the 2 position of the cyclohexyl skeleton and, more importantly, an increase in steric bulk at that point, led to a drastic reduction of side product formation (i.e., methyl- and methylenecyclopentane). Interestingly, additional methyl substitution in the 6 position of the cyclohexyl ring changed the selectivity of the catalyst from predominantly tetramerization to a 1:1 mixture of 1-hexene and 1-octene. Structurally similar ligands, such as cyclohexylmethyl and cyclohexylethyl PNP, were also tested and were also found to yield efficient tetramerization catalysts. It was concluded that structural fine tuning of the N-alkyl moiety of the PNP ligand is essential for obtaining efficient tetramerization catalysts, with the best systems achieving combined selectivities as high as 88% (1-octene and 1-hexene) with exceptionally high activities exceeding 2,000,000 g/(g-Cr h).
Chloroacetic acid cyclohexylamides, their preparation, their use for controlling weeds and agents for this use
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, (2008/06/13)
Novel chloroacetic acid cyclohexylamides of the formula I STR1 where R1, R2 and R3 have the meanings given in the description, their preparation and their use as herbicides.
