6850-63-1

Usage

Uses

Used in Pharmaceutical Industry:
2,6-Dimethylcyclohexylamine serves as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Dye Industry:
In the dye industry, 2,6-Dimethylcyclohexylamine is used as an intermediate for the production of dyes. Its chemical properties make it suitable for creating a range of colorants used in different applications, including textiles and plastics.
Used in Metalworking Fluids:
2,6-Dimethylcyclohexylamine functions as a corrosion inhibitor in metalworking fluids. It helps to prevent the corrosion of metal surfaces during manufacturing processes, thereby extending the life of machinery and improving the quality of the final product.
Used in Rubber Chemicals Production:
As a chemical intermediate, 2,6-Dimethylcyclohexylamine is involved in the production of rubber chemicals. It plays a role in enhancing the properties of rubber, such as its durability and resistance to wear.
Used in Surfactants Production:
In the production of surfactants, 2,6-Dimethylcyclohexylamine is utilized as a chemical intermediate. Surfactants are essential in various industries, including cosmetics, detergents, and industrial cleaning products, due to their ability to reduce surface tension and stabilize mixtures.

InChI:InChI=1/C8H17N/c1-6-4-3-5-7(2)8(6)9/h6-8H,3-5,9H2,1-2H3

Upstream product

• 7647-01-0 hydrogenchloride 
• 19187-65-6 N-(2,6-dimethylcyclohexylidene)hydroxylamine 
• 64-19-7 acetic acid 
• 64-17-5 ethanol 
• 87-62-7 2,6-dimethylaniline 
• 576-26-1 2.6-dimethylphenol 
• 7440-05-3 palladium 
• 6850-63-1 cis,trans-2,6-dimethylcyclohexylamine 
• 19187-65-6 trans-2,6-dimethylcyclohexanone oxime 
• 24213-44-3 cis,cis-2,6-dimethylcyclohexylamine 
• 2816-57-1 2,6-dimethylcyclohexanone 

Downstream Products

• 87-62-7 2,6-dimethylaniline 
• 6850-63-1 (+)-2r,6t-dimethyl-cyclohexylamine 
• 233756-71-3 cis-2,trans-6-Dimethylcyclohexanol 
• 766-43-8 trans-2,6-dimethylcyclohexanone 
• 42846-29-7 (1r*,2R*,6S*)-2,6-dimethylcyclohexanol 
• 24213-43-2 (+/-)-2-benzamino-1r.3t-dimethyl-cyclohexane 
• 42846-29-7 trans,trans-2,6-dimethylcyclohexanol 

Relevant academic research and scientific papers

SULPHONYL UREA DERIVATIVES AS NLRP3 INFLAMMASOME MODULATORS

The present disclosure relates to compounds of Formula (I): (I) and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

Highly selective amination of o-and p-alkyl phenols over Pd/Al 2O3-BaO

A series of Pd-based catalysts were prepared and examined for the amination of 2,6-dimethylphenol in a fixedbed reactor. The best results were obtained for Pd/Al2O3-BaO with a conversion of 99.89% and a selectivity of 91.16%. These catalysts were characterized using BET, XRD, XPS, TEM and NH3-TPD. Doped BaO not only improved the dispersion of the Pd particles but also decreased the acidity of the catalyst, which remarkably enhanced the selectivity and stability of the catalyst. The generality of Pd/Al 2O3-BaO for this kind of reaction was demonstrated by catalytic aminations of o- and p-alkyl phenols.

N-substituted diphosphinoamines: Toward rational ligand design for the efficient tetramerization of ethylene

Bis(diphenylphosphino)amine (PNP) ligands with different alkyl and cycloalkyl substituents attached to the N atom of the ligand backbone were synthesised and tested together with chromium as ethylene tetramerization catalysts. On activation with a methylaluminoxane-based activator, the catalysts displayed good activity and selectivity toward 1-octene and 1-hexene, with the best ligand systems containing cyclopentyl or cyclohexyl moieties. In addition, it was established that substitution at the 2 position of the cyclohexyl skeleton and, more importantly, an increase in steric bulk at that point, led to a drastic reduction of side product formation (i.e., methyl- and methylenecyclopentane). Interestingly, additional methyl substitution in the 6 position of the cyclohexyl ring changed the selectivity of the catalyst from predominantly tetramerization to a 1:1 mixture of 1-hexene and 1-octene. Structurally similar ligands, such as cyclohexylmethyl and cyclohexylethyl PNP, were also tested and were also found to yield efficient tetramerization catalysts. It was concluded that structural fine tuning of the N-alkyl moiety of the PNP ligand is essential for obtaining efficient tetramerization catalysts, with the best systems achieving combined selectivities as high as 88% (1-octene and 1-hexene) with exceptionally high activities exceeding 2,000,000 g/(g-Cr h).

Stereochemistry of hydrodenitrogenation: The mechanism of elimination of the amino group from cyclohexylamines over sulfided Ni-Mo/γ-Al2O3 catalysts

HDS and HDN are among the most significant catalytic processes in the petroleum industry, because during these processes sulfur and nitrogen are removed in the form of H2S and ammonia from oil fractions. The HDN of cyclohexylamine and of the diastereomers of 2-methylcyclohexylamine and 2,6-dimethylcyclohexylamine was studied at 200°-350°C and 50 bar over a sulfided Ni-Mo/γ-Al2O3 catalyst. The rate of HDN of alkyl-substituted cyclohexylamines over sulfided Ni-Mo catalysts depended on the number of β hydrogen atoms and on their stereochemical relation to the amino group. Isomerization of olefinic products and the amines prevented meaningful mechanistic studies at 350°C. The cis diastereomers reacted faster than the trans diastereomers, because they allowed for an anti geometric relationship in the chair conformation between the amino group and a hydrogen atom on a β carbon atom. The syn elimination occurred to a considerable extent at higher temperatures in molecules that were unable to undergo anti elimination. The activation energy of anti elimination was lower than that of syn elimination, and the activation energy of anti elimination involving a hydrogen atom attached to a tertiary β carbon atom was lower than that involving a hydrogen atom attached to secondary β carbon atom.

Chloroacetic acid cyclohexylamides, their preparation, their use for controlling weeds and agents for this use

Novel chloroacetic acid cyclohexylamides of the formula I STR1 where R1, R2 and R3 have the meanings given in the description, their preparation and their use as herbicides.

Branched amides of L-aspartyl-D-amino acid dipeptides

Amides of L-aspartyl-D-amino acid dipeptides of the formula STR1 and physiologically acceptable cationic and acid addition salts thereof wherein Ra is CH2 OH or CH2 OCH3 ; R is a branched member selected from the group consisting of fenchyl, diisopropylcarbinyl, d-methyl-t-butylcarbinyl, d-ethyl-t-butylcarbinyl, di-t-butylcarbinyl, 2-methylthio-2,4-dimethylpentan-3-yl, STR2 where at least one of R3, R4, R5, R6 is alkyl having from one to four carbon atoms and the remainder are hydrogen or alkyl having from one to four carbon atoms, X is O, S, SO, SO2, C=O or CHOH; m is zero or 1-4, n and p are each zero, 1, 2 or 3 where the sum of n+p is not greater than 3 and the sum of the carbon atoms in R3, R4, R5 and R6 is not greater than six, and when both of R3 and R4 or R5 and R6 are alkyl they are methyl or ethyl, STR3 where one of R7, R8, R9 is alkyl having from one to four carbon atoms and the remainder are hydrogen or alkyl having from one to four carbon atoms and the sum of the carbon atoms in R7, R8 and R9 is not greater than six, m and q are the same or different and each have the values previously defined for m; STR4 where each of R12 and R13 are methyl or ethyl, or R12 is hydrogen and R13 is alkyl having from one to four carbon atoms, Z is O or NH and t is 1 or 2, STR5 where W is 1-4, R14 and R16 are each alkyl having from one to four carbon atoms, R15 is H, OH, methyl or ethyl and the sum of the carbon atoms in R14, R15 and R16 is not greater than six and when both of R14 and R15 are alkyl they are methyl or ethyl, and STR6 where R17 and R19 are alkyl having from one to four carbon atoms, R18 and R20 are H or alkyl having one to two carbon atoms, A is OH and B is H, OH or CH3 and taken together A and B are STR7 where the sum of the carbon atoms in R17, R18, R19 and R20 is not greater than six and when both of R17 and R18 or R19 and R20 are alkyl they are methyl or ethyl; said amides are potent sweeteners having advantages over the prior art, edible compositions containing them, methods for their use in edible compositions and novel amide intermediates useful in their production.

Preparation of aromatic amines

Aromatic amines (anilines) are obtained directly or via the corresponding cycloaliphatic amines by an aminating/hydrogenating reaction of phenols with ammonia and hydrogen over a supported palladium catalyst which also contains elements from group 1b, 2b or 7b of the periodic table as well as iron, cobalt or nickel, as such or in the form of their compounds, and, preferably, an inorganic base, said catalysts also having dehydrogenating properties.