68719-57-3

Basic information

• Product Name: 5-methyl-4-((4-nitrophenyl)thio)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
• CAS NO: 68719-57-3
• Molecular Weight: 327.364
• Mol File: 68719-57-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-methyl-4-((4-nitrophenyl)thio)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-4-((4-nitrophenyl)thio)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one(68719-57-3)
• EPA Substance Registry System: 5-methyl-4-((4-nitrophenyl)thio)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one(68719-57-3)

Safety Data

• Hazardous Substances Data: 68719-57-3(Hazardous Substances Data)

Upstream product

• 19735-89-8 3-methyl-1-phenylpyrazolin-5(4H)-one 
• 100-32-3 di(p-nitrophenyl) disulfide 
• 1849-36-1 para-nitrobenzenethiol 
• 59-88-1 phenylhydrazine hydrochloride 
• 636-98-6 p-nitrobenzene iodide 
• 89-25-8 edaravone 
• 70925-55-2 2-oxo-1-ethoxycarbonylpropyl 4-nitrophenyl sulfide 
• 100-63-0 phenylhydrazine 
• 68719-56-2 4-bromo-5-methyl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 13113-79-6 sodium 4-nitrobenzenethiolate 

Relevant articles and documents

One-flask synthesis of pyrazolone thioethers involving catalyzed and uncatalyzed thioetherification pathways of pyrazolones

A one-flask thioetherification of pyrazolones has been demonstrated by transforming several pyrazolones to their corresponding 4-mercaptopyrazolone derivatives and employing them towards cross-coupling with various aromatic and heteroaromatic iodides by applying Pd(OAc)2/xantphos as the catalytic system. The coupling ability of these thiol intermediates with 2,3-dichloropyrazine through an aromatic SN2 pathway has also been established. This methodology provides the use of inexpensive starting materials along with a short reaction time.