69333-48-8Relevant academic research and scientific papers
Divergent Ritter-type amination: Via photoredox catalytic four-component radical-polar crossover reactions
Chen, Zhao-Xu,Guo, Sheng-Qiang,Jiang, Yu-Zhen,Luo, Yong-Chun,Wang, Ai-Lian,Xu, Guo-Qiang,Xu, Peng-Fei,Yang, Hui-Qing
supporting information, p. 9571 - 9576 (2021/12/09)
A green and practical divergent Ritter-type amination via a photoredox catalytic four-component radical-polar crossover process was developed. This versatile protocol presents a modular and powerful strategy to access functionalized β-sulfonyl imides and imines under mild conditions from readily available and stable substrates with high atom-, step- and redox economy. We manipulated carboxylic acids and benzotriazoles to precisely attack the nitrilium ion instead of the carbocation, thus preventing many complicated side reactions of the photocatalytic reactions. Furthermore, the synthetic utility of this divergent Ritter reaction is further demonstrated by the late-stage modification of pharmaceutical and natural product derivatives. This journal is
NUCLEOPHILIC ADDITION TO STYRYL SULPHONES. PART I. A STUDY ON THE REGIOCHEMISTRY.
Benedetti, F.,Fabrissin, S.,Risaliti, A.
, p. 3887 - 3894 (2007/10/02)
Styryl sulphones undergo nucleophilic addition, with the nucleophile adding at the α- or the β-position, with respect to the sulphone group; β-attack is normally favoured over α-attack.Factors which can change the regioselectivity in favour of the addition of the nucleophile to the α-position are discussed for heteronucleophiles as well as carbon nucleophiles.
