69709-34-8

Basic information

• Product Name: Benzene, 1-nitro-2-[(phenylsulfonyl)methyl]-
• CAS NO: 69709-34-8
• Molecular Formula: C13H11NO4S
• Molecular Weight: 277.301
• Mol File: 69709-34-8.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzene, 1-nitro-2-[(phenylsulfonyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-nitro-2-[(phenylsulfonyl)methyl]-(69709-34-8)
• EPA Substance Registry System: Benzene, 1-nitro-2-[(phenylsulfonyl)methyl]-(69709-34-8)

Safety Data

• Hazardous Substances Data: 69709-34-8(Hazardous Substances Data)

Upstream product

• 873-55-2 sodium benzenesulfonate 
• 612-23-7 2-nitrobenzyl chloride 
• 1212-08-4 S-Phenyl benzenethiosulfonate 
• 3958-60-9 2-nitrophenylmethyl bromide 
• 7205-98-3 chloromethyl phenyl sulfone 
• 98-95-3 nitrobenzene 
• 88-73-3 2-Chloronitrobenzene 
• 100-00-5 4-chlorobenzonitrile 
• 620-88-2 4-nitrophenyl phenyl ether 
• 3282-56-2 4-tert-butylnitrobenzene 
• 100-17-4 para-methoxynitrobenzene 
• 91718-67-1 (2-nitrobenzyl)(phenyl)sulfane 
• 65492-21-9 ((Iodomethyl)sulfonyl)benzene 
• 20808-12-2 fluoromethyl phenyl sulfone 

Downstream Products

• 790657-30-6 N,N-dimethyl-N-{2-[3-(phenylsulfonyl)-1H-indol-1-yl]ethyl}amine 
• 107266-93-3 N-(2-Benzenesulfonylmethyl-phenyl)-acetimidic acid methyl ester 
• 107267-01-6 2-methyl-3-(phenylsulfonyl)-1H-indole 
• 133437-43-1 3-(phenylsulfonyl)-1H-indole 
• 60986-51-8 2-[2-phenylethenyl]-1H-indole 
• 55968-16-6 2-(2-thienyl)indole 
• 948-65-2 2-phenyl-indole 
• 869301-75-7 N-[2-((1Z,3E)-1-Benzenesulfonyl-4-phenyl-buta-1,3-dienyl)-phenyl]-2,2,2-trifluoro-acetamide 
• 869301-74-6 N-[2-(1-benzenesulfonyl-2-thiophen-2-yl-vinyl)-phenyl]-2,2,2-trifluoro-acetamide 
• 869301-73-5 N-[2-(1-benzenesulfonyl-2-phenyl-vinyl)-phenyl]-2,2,2-trifluoro-acetamide 
• 869301-68-8 N-(2-benzenesulfonylmethyl-phenyl)-2,2,2-trifluoro-acetamide 
• 95539-67-6 2-[(phenylsulfonyl)methyl]aniline 

Relevant articles and documents

MANUFACTURING METHOD OF COMPOUND HAVING SULFONYL GROUP

The present invention relates to a method for manufacturing a compound having a sulfonyl group, which includes a step for reacting thiosulfonates in a solvent comprising nucleophilic bases with an electrophilic agent. Accordingly, the present invention can manufacture the compound having the sulfonyl group with a variety of structures with high efficiency and high yield through more simplified processes than conventional methods.COPYRIGHT KIPO 2018

3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT6 receptor modulators

Novel 3-(arylsulfonyl)-1-(azacyclyl)-1H-indoles 6 were synthesized as potential 5-HT6 receptor ligands, based on constraining a basic side chain as either a piperidine or a pyrrolidine. Many of these compounds had good 5-HT6 binding affinity with Ki values 50 = 60 nM, Emax = 70%) and antagonists (6y: IC50 = 17 nM, Imax = 86%) were identified in a 5-HT6 adenylyl cyclase assay.

Novel synthesis of 2-aryl and 2,3-disubstituted indoles by modified double elimination protocol

(Chemical Equation Presented) Syntheses of 2-aryl and 2,3-substituted indoles were realized by modified double elimination protocol. Under basic conditions, vinyl sulfones derived from the reaction of 2-aminobenzyl sulfone with benzaldehydes underwent cyclization and alkylation followed by elimination of sulfinic acid to afford 2,3-substituted indoles.