790657-30-6

Upstream product

• 124-40-3 dimethyl amine 
• 133437-43-1 3-(phenylsulfonyl)-1H-indole 
• 108-98-5 thiophenol 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 69709-34-8 2-(phenylsulfonylmethyl)-1-nitrobenzene 
• 95539-67-6 2-[(phenylsulfonyl)methyl]aniline 
• 7205-98-3 chloromethyl phenyl sulfone 
• 54491-43-9 3-phenylthioindole 
• 120-72-9 indole 
• 98-95-3 nitrobenzene 

Relevant academic research and scientific papers

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-indoles as novel 5-HT6 receptor ligands

Novel 1-(2-aminoethyl)-3-(arylsulfonyl)-1H-indoles were prepared. Binding assays indicated they are 5-HT6 receptor ligands, among which N,N-dimethyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8t and N-methyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8u showed high affinity for 5-HT6 receptors with Ki = 3.7 and 5.7 nM, respectively. Novel 1-(2-aminoethyl)-3-(arylsulfonyl)-1H-indoles were prepared. Binding assays indicated they are 5-HT6 receptor ligands, among which N,N-dimethyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8t and N-methyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8u showed high affinity for 5-HT6 receptors with Ki = 3.7 and 5.7 nM, respectively.

1-(AMINOALKYL)-3-SULFONYLINDOLE AND-INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS

The present invention provides compounds of formula I and the use thereof for the treatment of central nervous system disorders related to or affected by the 5-HT6 receptor.