700-78-7

Basic information

• Product Name: 6-chloroquinazoline
• Synonyms: 6-chloroquinazoline
• CAS NO: 700-78-7
• Molecular Formula: C8H5ClN2
• Molecular Weight: 164.5917
• Product Categories: CHIRAL CHEMICALS
• Mol File: 700-78-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 142-143 °C
• Boiling Point: 281 °C at 760 mmHg
• Flash Point: 150.6 °C
• Appearance: /
• Density: 1.349 g/cm³
• Vapor Pressure: 0.00624mmHg at 25°C
• Refractive Index: 1.662
• Storage Temp.: 2-8°C
• PKA: 3.61±0.26(Predicted)
• CAS DataBase Reference: 6-chloroquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloroquinazoline(700-78-7)
• EPA Substance Registry System: 6-chloroquinazoline(700-78-7)

Safety Data

• Hazardous Substances Data: 700-78-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron, 62, p. 12351, 2006 DOI: 10.1016/j.tet.2006.09.103

InChI:InChI=1/C8H5ClN2/c9-7-1-2-8-6(3-7)4-10-5-11-8/h1-5H

Upstream product

• 101421-72-1 6-amino-quinazoline 
• 90537-73-8 N,N'-(5-chloro-2-nitro-benzylidene)-bis-formamide 
• 64-19-7 acetic acid 
• 100-97-0 hexamethylenetetramine 
• 2621-80-9 ethyl p-chlorophenylcarbamate 
• 6628-86-0 5-chloro-2-nitrobenzaldehyde 
• 110-18-9 N,N,N,N,-tetramethylethylenediamine 
• 20028-53-9 2-amino-5-chlorobenzaldehyde 
• 127-19-5 N,N-dimethyl acetamide 
• 67567-44-6 (5-chloro-2-nitrophenyl)-methylamine 
• 106-47-8 4-chloro-aniline 
• 108047-39-8 2-(aminomethyl)-4-chloroaniline 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 932368-51-9 6-ethenylquinazoline 
• 439811-22-0 quinazoline-6-carbaldehyde 

Relevant articles and documents

I2-catalyzed aerobic oxidative C(sp3)-H amination/C-N cleavage of tertiary amine: Synthesis of quinazolines and quinazolinones

An iodine-catalyzed oxidative C(sp3)-H amination/C-N cleavage of tertiary amines couducted under an oxygen atmosphere has been developed and affords a route to quinazolines and quinazolinones in good to excellent yields via a domino ring annulation. The method is metal-free, peroxide-free, and operationally simple to implement with a wide scope of substrates and represents a new avenue for multiple C-N bond formations.

NOVEL CHEMICAL COMPOUNDS

This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with the imbalance or inappropriate activity of hYAK3 proteins.

A microwave improvement in the synthesis of the quinazoline scaffold

A rapid and efficient microwave-assisted protocol is described that greatly improves a recent synthetic method developed for quinazoline synthesis. The synthetic protocol is based on the use of cycles of microwave irradiation. The optimization process is reported and the experimental results are compared with those of the conventional synthetic route.