700-78-7

Usage

Synthesis Reference(s)

Tetrahedron, 62, p. 12351, 2006 DOI: 10.1016/j.tet.2006.09.103

InChI:InChI=1/C8H5ClN2/c9-7-1-2-8-6(3-7)4-10-5-11-8/h1-5H

Upstream product

• 101421-72-1 6-amino-quinazoline 
• 90537-73-8 N,N'-(5-chloro-2-nitro-benzylidene)-bis-formamide 
• 108047-39-8 2-(aminomethyl)-4-chloroaniline 
• 122-51-0 orthoformic acid triethyl ester 
• 64-19-7 acetic acid 
• 100-97-0 hexamethylenetetramine 
• 2621-80-9 ethyl p-chlorophenylcarbamate 
• 106-47-8 4-chloro-aniline 
• 67567-44-6 (5-chloro-2-nitrophenyl)-methylamine 
• 6628-86-0 5-chloro-2-nitrobenzaldehyde 
• 127-19-5 N,N-dimethyl acetamide 
• 20028-53-9 2-amino-5-chlorobenzaldehyde 
• 110-18-9 N,N,N,N,-tetramethylethylenediamine 

Downstream Products

• 932368-51-9 6-ethenylquinazoline 
• 439811-22-0 quinazoline-6-carbaldehyde 

Relevant academic research and scientific papers

I2-catalyzed aerobic oxidative C(sp3)-H amination/C-N cleavage of tertiary amine: Synthesis of quinazolines and quinazolinones

An iodine-catalyzed oxidative C(sp3)-H amination/C-N cleavage of tertiary amines couducted under an oxygen atmosphere has been developed and affords a route to quinazolines and quinazolinones in good to excellent yields via a domino ring annulation. The method is metal-free, peroxide-free, and operationally simple to implement with a wide scope of substrates and represents a new avenue for multiple C-N bond formations.

Selective iodine-catalyzed intermolecular oxidative amination of C(sp 3)-H bonds with ortho-carbonyl-substituted anilines to give quinazolines

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