700-79-8

Basic information

• Product Name: Quinazoline, 2-methyl- (6CI,7CI,8CI,9CI)
• Synonyms: Quinazoline, 2-methyl- (6CI,7CI,8CI,9CI);2-Methylquinazoline;2-Methylquinazoline ,≥96%
• CAS NO: 700-79-8
• Molecular Formula: C₉H₈N₂
• Molecular Weight: 144.17
• Product Categories: PYRIMIDINE
• Mol File: 700-79-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 37-38℃
• Boiling Point: 61℃ (20 Torr)
• Appearance: /
• Density: 1.141±0.06 g/cm3(Predicted)
• PKA: 4.30±0.39(Predicted)
• CAS DataBase Reference: Quinazoline, 2-methyl- (6CI,7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Quinazoline, 2-methyl- (6CI,7CI,8CI,9CI)(700-79-8)
• EPA Substance Registry System: Quinazoline, 2-methyl- (6CI,7CI,8CI,9CI)(700-79-8)

Safety Data

• Hazardous Substances Data: 700-79-8(Hazardous Substances Data)

Usage

General Description

Quinazoline, 2-methyl- (6CI,7CI,8CI,9CI) is a chemical compound that belongs to the quinazoline family. It is characterized by a quinazoline ring with a methyl group attached to the 2-position. Quinazoline, 2-methyl- (6CI,7CI,8CI,9CI) has potential applications in the pharmaceutical industry, as quinazoline derivatives have been studied for their various biological activities, including anticancer, antiviral, and antifungal properties. The 2-methyl substitution may alter the compound's biological and pharmacological properties, making it a subject of interest for further research and development. Additionally, it is important to carefully handle and store this compound in compliance with safety regulations and guidelines.

Upstream product

• 612-62-4 2-Chloroquinoline 
• 75-05-8 acetonitrile 
• 104-87-0 4-methyl-benzaldehyde 
• 116944-06-0 3-benzoyl-3,4-dihydro-2-methyl-4-quinazolinecarbonitrile 
• 100-52-7 benzaldehyde 
• 6484-28-2 2-methyl-4(3H)-quinazolinethione 

Downstream Products

• 116944-06-0 3-benzoyl-3,4-dihydro-2-methyl-4-quinazolinecarbonitrile 
• 116944-12-8 4-(2-acetamidophenyl)-5-amino-2-phenyloxazole 
• 1620483-84-2 (E)-2-(4-piperidin-1-ylstyryl)quinazoline 
• 1620483-83-1 (E)-2-(4-diphenylaminostyryl)quinazoline 
• 1620483-75-1 (E)-2-(4-dimethylaminostyryl)quinazoline 
• 3440-47-9 (E)-2-styrylquinazoline 
• 568630-14-8 quinazoline-2-carboxylic acid 
• 1769-24-0 2-methyl-4-quinazolone 
• 101444-30-8 (E)-2-(4-methoxystyryl)quinazoline 

Relevant articles and documents

Reactions of 3-Benzoyl-3,4-dihydro-2-methyl-4-quinazolinecarbonitrile (2-Methylquinazoline Reissert Compound) with Acid, Base, Sodium Hydride, and Electrophiles

Acid hydrolysis of 3-benzoyl-3,4-dihydro-2-methyl-4-quinazolinecarbonitrile (11, 2-methylquinazoline Reissert compound) resulted in the formation of the oxazole (13).Alkaline hydrolysis gave 2-methylquinazoline (12) and banzoic acid (8).The anion (D1), generated from 11 and NaH in dimethylformamide (DMF), underwent decomposition to give the ketone (14) and the cyanoquinazoline (15) together with by-products 12 and O-benzoylbenzoin (9).Compound 11 reacted with aromatic aldehydes (10a-c) in the presence of NaH to give the benzoates (16a-c) and by-products 12 and 15.Alkylation (or arylation) with alkyl (or aryl) halides (11a, b) afforded the corresponding 4-substituted derivatives (19a, b) and a by-product 14.The reactivities of 11 and 3-benzoyl-3,4-dihydro-4-quinazolinecarbonitrile (21, quinazoline Reissert compound) are compared. Keywords---Reissert compound; quinazoline; hydrolysis; Reissert compound anion; rearrengement; aromatization; electronic effect; electrophilic substitution

Photostimulated Reactions of 2-Bromopyridine and 2-Chloroquinoline with Nitrile-Stabilized Carbanions and Certain Other Nucleophiles

Potassiophenylacetonitrile (2) reacts with 2-bromopyridine (1) and 2-chloroquinoline (4) via the SRN1 mechanism when the reactants are exposed to near-UV light in liquid NH3.Potassioacetonitrile (6) reacts similarly with 1 and 4 upon photostimulation; however, the photo-SRN1 reaction with 1 is accompanied by SNAr2 amination which becomes the major reaction in the dark or in the presence of di-tert-butyl nitroxide.Substrate 4 undergoes competing SNAr2 amination with amide ion to form 2-aminoquinoline (10) and SN(ANRORC) reactions with both amide ion and carban ion 6 to form 3-methylquinazoline (11) and 2-methyl-3-cyanoquinoline (12), respectively.Formation of 12 becomes the major pathway in reactions between 4 and 6 carried out in the dark. 4-Picolylpotassium (14) reacts with 1, 4, and 4-bromopyridinium chloride (16) under photostimulation to form the appropriate dihetarylmethanes, along with the corresponding amino heterocycles.Amination of 1, 4, and 16 predominates when these reactions are carried out in the dark.Ammonium thiophenoxide (20) undergoes a slow photo-SRN1 reaction with 1 but fails to produce the expected 2-quinolyl phenyl sulfide with 4 after 2 h of irradiation.Potassium salts of acetylene, phenylacetylene, and phthalimide do not react with 1 or 4 after 2 h of exposure to near-UV light.