70138-31-7

Usage

Uses

Used in Chemical Synthesis:
3,3,3-Trimethoxypropionitrile is used as an intermediate in the chemical synthesis of malonoand succinonitriles. Its unique structure allows for the creation of a wide range of compounds with diverse applications across different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3,3,3-Trimethoxypropionitrile is used as a key building block for the synthesis of various drug molecules. Its versatility in chemical reactions enables the development of new therapeutic agents with potential applications in treating various diseases and medical conditions.
Used in Agrochemical Industry:
3,3,3-Trimethoxypropionitrile is also utilized in the agrochemical industry for the synthesis of compounds with pesticidal, herbicidal, and fungicidal properties. Its role as an intermediate allows for the development of more effective and targeted agrochemicals to protect crops and enhance agricultural productivity.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 3,3,3-Trimethoxypropionitrile is employed as an intermediate for the synthesis of various colorants and pigments. Its unique chemical structure contributes to the development of new dyes and pigments with improved properties, such as enhanced color strength, stability, and resistance to fading.
Overall, 3,3,3-Trimethoxypropionitrile is a versatile intermediate with a wide range of applications across different industries, including pharmaceuticals, agrochemicals, and dyes and pigments. Its unique structure and reactivity make it a valuable compound for the synthesis of various products with diverse uses and benefits.

InChI:InChI=1/C6H11NO3/c1-8-6(9-2,10-3)4-5-7/h4H2,1-3H3

Upstream product

• 53557-70-3 methyl 2-cyanoacetimidate hydrochloride 
• 67-56-1 methanol 
• 7647-01-0 hydrogenchloride 
• 15732-02-2 1-cyano-2,2-bis(methoxy)ethylene 
• 7436-85-3 3,3-dichloro-acrylonitrile 
• 124-41-4 sodium methylate 

Downstream Products

• 15732-02-2 1-cyano-2,2-bis(methoxy)ethylene 
• 372-09-8 cyanoacetic acid 
• 105-34-0 methyl 2-cyanoacetate 
• 108-59-8 malonic acid dimethyl ester 
• 155495-55-9 methyl-2-cyano-N-phenylacetimidate 
• 93692-43-4 1-anilino-1,2-dicyanoethylene 
• 155495-57-1 methyl 2-cyano-N-(3-methanesulfonamido)-phenylacetimidate 
• 110884-53-2 5-methoxy-1H-pyrazol-3-amine hydrochloride 

Relevant academic research and scientific papers

PYRAZOLYL-AMINO-SUBSTITUTED PYRAZINES AND THEIR USE FOR THE TREATMENT OF CANCER

The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These novel compounds provide a treatment for myeloproliferative disorders and cancer.

Process for preparing 1,2,4-thiadiazole derivatives

An improved process for the production of 5-amino-1,2,4-thiadiazol-3-yl-(2-(lower)-alkoxyimino)acetic acids starting from 5-substituted- or unsubstituted-3-amino-isoxazole compounds is disclosed herein. The title compounds are useful as acylating agents for the production of 7-acylaminocephalosporins.

Practical preparation of (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetic acid: A side-chain of the fourth generation of cephem antibiotics

A Z-isomer (4) of 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid, which is the common acyl moiety of clinically useful cephem antibiotics, has been prepared from the aminoisoxazoles through the skeletal rearrangement in several routes. Reaction of 3-amino-5-methoxyisoxazole (7) with alkoxycarbonyl isothiocyanates gave methyl 2-(5-alkoxycarbonylamino-1,2,4-thiadiazol-3-yl)acetates (8), which were converted into the target compound 4 through the reaction of the corresponding keto ester with O-methylhydroxylamime. Compound 4 was prepared similarly from 3-aminoisoxazole (10). Also, O-methylation of 2-hydroxyimino-2-(5-methoxycarbonylamino-1,2,4-thiazol-3-yl)acetate (15) with methyl iodide or dimethyl sulfate in the presence of barium oxide and barium hydroxide octahydrate was found to afford exclusively the desired Z-isomer (14a) of methyl 2-(5-methoxycarbonylamino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)aceta te, which was led to 4.

Synthesis and evaluation of antiinflammatory activities of a series of corticosteroid 17α-esters containing a functional group

A series of 21-desoxy-21-chlorocorticosteroids that contain a functionalized ester group at 17α has been prepared and examined to separate their systemic activity from topical antiinflammatory activity. Introduction of the functionalized ester group at 17α was carried out by an acid-catalyzed formation of cyclic ortho esters with 17α,21-hydroxyl groups of corticosteroids and subsequent acid-catalyzed hydrolysis. As for the functional group, chloro, methoxy, acetoxy, cyano, cyclopropyl, or alkoxycarbonyl group was introduced at the terminal carbon atom of the 17α-alkanoate group. The topical antiinflammatory activity and systemic activity of these compounds were examined and found to be signficantly dependent on the functionalities in the 17α-esters. Among these derivatives, a series of 17α-(alkoxycarbonyl)alkanoates (17α-OCO(CH2)(n)COOR) showed an excellent separation of the systemic activity from topical activity. The effects of the number of methylene groups (n) and of the alkyl groups of the ester (R) on either topical or systemic activity of the corticosteroid derivatives were also investigated.