70138-31-7

Basic information

• Product Name: 3,3,3-Trimethoxypropionitrile
• Synonyms: 3,3,3-Trimethoxypropionitrile;3,3,3-trimethoxypropanenitrile
• CAS NO: 70138-31-7
• Molecular Formula: C₆H₁₁NO₃
• Molecular Weight: 145.16
• Mol File: 70138-31-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 227°C at 760 mmHg
• Flash Point: 91.2°C
• Appearance: /
• Density: 1.036
• Vapor Pressure: 0.0796mmHg at 25°C
• Refractive Index: 1.413
• Storage Temp.: Hygroscopic, Refrigerator, Under inert atmosphere
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: 3,3,3-Trimethoxypropionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3,3-Trimethoxypropionitrile(70138-31-7)
• EPA Substance Registry System: 3,3,3-Trimethoxypropionitrile(70138-31-7)

Safety Data

• Hazardous Substances Data: 70138-31-7(Hazardous Substances Data)

Usage

Uses

3,3,3-Trimethoxypropanenitrile is an intermdiate in the synthesis of related compounds of malono- and succinonitriles.

InChI:InChI=1/C6H11NO3/c1-8-6(9-2,10-3)4-5-7/h4H2,1-3H3

Upstream product

• 7436-85-3 3,3-dichloro-acrylonitrile 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 
• 53557-70-3 methyl 2-cyanoacetimidate hydrochloride 
• 7647-01-0 hydrogenchloride 
• 15732-02-2 1-cyano-2,2-bis(methoxy)ethylene 

Downstream Products

• 15732-02-2 1-cyano-2,2-bis(methoxy)ethylene 
• 105-34-0 methyl 2-cyanoacetate 
• 108-59-8 malonic acid dimethyl ester 
• 110884-53-2 5-methoxy-1H-pyrazol-3-amine hydrochloride 
• 155495-57-1 methyl 2-cyano-N-(3-methanesulfonamido)-phenylacetimidate 
• 155495-55-9 methyl-2-cyano-N-phenylacetimidate 
• 93692-43-4 1-anilino-1,2-dicyanoethylene 
• 372-09-8 cyanoacetic acid 

Relevant articles and documents

PYRAZOLYL-AMINO-SUBSTITUTED PYRAZINES AND THEIR USE FOR THE TREATMENT OF CANCER

The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These novel compounds provide a treatment for myeloproliferative disorders and cancer.

Practical preparation of (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetic acid: A side-chain of the fourth generation of cephem antibiotics

A Z-isomer (4) of 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid, which is the common acyl moiety of clinically useful cephem antibiotics, has been prepared from the aminoisoxazoles through the skeletal rearrangement in several routes. Reaction of 3-amino-5-methoxyisoxazole (7) with alkoxycarbonyl isothiocyanates gave methyl 2-(5-alkoxycarbonylamino-1,2,4-thiadiazol-3-yl)acetates (8), which were converted into the target compound 4 through the reaction of the corresponding keto ester with O-methylhydroxylamime. Compound 4 was prepared similarly from 3-aminoisoxazole (10). Also, O-methylation of 2-hydroxyimino-2-(5-methoxycarbonylamino-1,2,4-thiazol-3-yl)acetate (15) with methyl iodide or dimethyl sulfate in the presence of barium oxide and barium hydroxide octahydrate was found to afford exclusively the desired Z-isomer (14a) of methyl 2-(5-methoxycarbonylamino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)aceta te, which was led to 4.