70150-60-6

Basic information

• Product Name: 2-Butenoic acid, 4-(phenylmethoxy)-, ethyl ester, (2E)-
• CAS NO: 70150-60-6
• Molecular Formula: C13H16O3
• Molecular Weight: 220.268
• Mol File: 70150-60-6.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 2-Butenoic acid, 4-(phenylmethoxy)-, ethyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 4-(phenylmethoxy)-, ethyl ester, (2E)-(70150-60-6)
• EPA Substance Registry System: 2-Butenoic acid, 4-(phenylmethoxy)-, ethyl ester, (2E)-(70150-60-6)

Safety Data

• Hazardous Substances Data: 70150-60-6(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 100-51-6 benzyl alcohol 
• 32122-09-1 ethyl benzyloxyacetate 
• 69010-01-1 (2R*,3S*)-1,4-bis(benzyloxy)butane-2,3-diol 
• 68972-96-3 (Z)-1,4-dibenzyloxy-2-butene 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 60656-87-3 benzyloxyacetoaldehyde 
• 20194-18-7 sodium phenyl-methanolate 
• 71516-48-8 2-((benzyloxy)methyl)-1,3-dioxolane 
• 4341-76-8 Ethyl 2-butynoate 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 622-08-2 2-Benzyloxyethanol 

Downstream Products

• 1092696-26-8 (E)-((4-(benzyloxy)but-2-en-1-yl)oxy)(tert-butyl)diphenylsilane 
• 1176702-27-4 (S,E)-3-(4-(benzyloxy)but-2-enoyl)-4-phenyloxazolidin-2-one 

Relevant articles and documents

POLYMYXIN ANALOGS USEFUL AS ANTIBIOTIC POTENTIATORS

The disclosure provides compounds of the formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt of either of the foregoing. The variables A, R1, and R2 are defined in the disclosure. The disclosure further includes pharmaceutical compositions comprising a compound of formula I together with at least one pharmaceutically acceptable carrier. The disclosure also includes a method of sensitizing bacteria to an antibacterial agent, comprising administering to a patient infected with the bacteria, simultaneously or sequentially, a therapeutically effective amount of the antibacterial agent and a compound of formula (I).

Total synthesis of (-)-bicubebin A, B, (+)-bicubebin C and structural reassignment of (-)-cis-cubebin

The first total synthesis of (-)-bicubebin A, and two previously unreported dilignans, (-)-bicubebin B and (+)-bicubebin C has been achieved through the dimerization of (-)-cubebin, confirming the structure and absolute stereochemistry of (-)-bicubebin A. Analysis of the data for (-)-bicubebin B showed it matched that of reported compound (-)-cis-cubebin. The NMR data of the subsequently synthesized proposed structure of cis-cubebin confirmed that its original proposed structure was incorrect.

Syn-effect' in the diastereoselective alkylation of 3-[(E)-α,β-unsaturated-γ-substituted]-N-acyloxazolidinones

Synthetic methods for the formation of alkenes usually produce the E-alkene because it is more stable. However, in isomerization reaction (double bond migration) that takes place in α, β-unsaturated carbonyl compounds, when these carbonyl compounds are exposed to strong bases, furnish Z-alkenes highly stereoselective depending on the γ-substituent in the α, β-unsaturated carbonyl. This stereoselectivity can be attributed to the known Syn-effect. The synthetic value of this methodology is the achievement of chiral alcohol bearing an electron rich Z-alkene, as well as substituted, which was accomplished via removal of the oxazolidinone moiety under treatment with NaBH4, THF-H2O.