708-58-7

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Fluoro-2-nitrophenyl)acetonitrile is used as a key intermediate for the synthesis of various pharmaceutical products. Its unique structure allows for the development of new drugs with potential therapeutic applications, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(4-Fluoro-2-nitrophenyl)acetonitrile is employed as a precursor in the production of agrochemicals. Its incorporation into these products can enhance their effectiveness in agricultural applications, such as pest control and crop protection.
Used in Organic Synthesis:
2-(4-Fluoro-2-nitrophenyl)acetonitrile is utilized as a versatile building block in organic synthesis. Its reactivity and structural features make it suitable for the preparation of a wide array of organic compounds, including dyes and pigments, which find applications in various industries such as textiles, plastics, and inks.
Used in Research and Development:
2-(4-Fluoro-2-nitrophenyl)acetonitrile is also used in research and development settings to explore its potential applications and properties. Scientists and researchers leverage 2-(4-Fluoro-2-nitrophenyl)acetonitrile to investigate new chemical reactions and pathways, contributing to the broader understanding of organic chemistry and its practical applications.

Upstream product

• 728-00-7 4-Fluor-2-nitro-α-cyan-phenylessigsaeure-aethylester 
• 61540-35-0 S-(Dimethylthiocarbamoyl)thioglycolonitrile 
• 402-67-5 3-fluoro-1-nitrobenzene 
• 3598-14-9 phenoxyacetonitrile 
• 107-14-2 chloroacetonitrile 
• 540-36-3 para-difluorobenzene 
• 364-74-9 1,4-difluoro-2-nitrobenzene 
• 67567-46-8 2‐(bromomethyl)‐4‐methoxy‐1‐nitrobenzene 
• 5367-32-8 5-methoxy-2-nitrotoluene 
• 7677-24-9 trimethylsilyl cyanide 
• 76437-44-0 1-(bromomethyl)-4-fluoro-2-nitrobenzene 

Relevant academic research and scientific papers

Mn(III)-Mediated Radical Cyclization of o-Alkenyl Aromatic Isocyanides with Boronic Acids: Access to N-Unprotected 2-Aryl-3-cyanoindoles

The synthesis of N-unprotected 2-aryl-3-cyanoindoles was realized via the Mn(III)-mediated radical cascade cyclization of o-alkenyl aromatic isocyanides with boronic acids. A possible mechanism involving a sequential intermolecular radical addition, intramolecular cyclization, and cleavage of the C-C bond under mild reaction conditions is proposed. Mechanism studies show that H2O or O2 might provide the oxygen source for the elimination of benzaldehyde.

Trifluoromethylation/Difluoromethylation-Initiated Radical Cyclization of o-Alkenyl Aromatic Isocyanides for Direct Construction of 4-Cyano-2-Trifluoromethyl/Difluoromethyl-Containing Quinolines

In this study, a radical-triggered cyclization of o-alkenyl aromatic isocyanides prepared from accessible starting materials is developed. The reaction provides a general and efficient method for the synthesis of 4-CN-2-CF3/CF2H-cont

Synthesis of pyrazolo[1,5- c] quinazoline derivatives through the copper-catalyzed domino reaction of o -alkenyl aromatic isocyanides with diazo compounds

A novel copper-catalyzed domino reaction between o-alkenyl aromatic isocyanides and diazo compounds has been developed under mild reaction conditions. Various o-alkenyl aromatic isocyanides were prepared from readily available reactants. The reaction prov

Palladium-Catalyzed Dual Annulation: A Method for the Synthesis of Norneocryptolepine

A novel procedure for the Pd-catalyzed dual annulation reaction to synthesize the norneocryptolepine derivatives involving the concerted construction of two central heterocycles is reported. The further methylation of the norneocryptolepine to afford its alkaloid analog neocryptolepine implies that synthesis of various neocryptolepine derivatives is feasible. The oxidative addition of Pd(0) is indicated as the key step to activate the intramolecular addition of nitrile according to the mechanism study.

Specific ortho-Cyanomethylation of Nitroarenes via the Vicarious Nucleophilic Substitution of Hydrogen

The vicarious nucleophilic substitution of hydrogen in nitroarenes with acetonitrile derivatives XCH2CN in t-BuOK/THF base/solvent system proceeds exclusively ortho to the nitro group.Strong influence of substituents Z in 3-Z-nitrobenzene derivatives on the orientation has been observed.