708-58-7

Basic information

• Product Name: 2-(4-Fluoro-2-nitrophenyl)acetonitrile
• Synonyms: 2-(4-Fluoro-2-nitrophenyl)acetonitrile;(4-Fluoro-2-nitro-phenyl)-acetonitrile
• CAS NO: 708-58-7
• Molecular Formula: C₈H₅FN₂O₂
• Molecular Weight: 180.1359032
• Mol File: 708-58-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-Fluoro-2-nitrophenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Fluoro-2-nitrophenyl)acetonitrile(708-58-7)
• EPA Substance Registry System: 2-(4-Fluoro-2-nitrophenyl)acetonitrile(708-58-7)

Safety Data

• Hazardous Substances Data: 708-58-7(Hazardous Substances Data)

Usage

General Description

2-(4-Fluoro-2-nitrophenyl)acetonitrile is a chemical compound with the molecular formula C8H6FN2O2. It is a yellow solid that is commonly used in organic synthesis, particularly in the pharmaceutical industry. 2-(4-Fluoro-2-nitrophenyl)acetonitrile is known for its ability to act as a versatile building block in the preparation of various pharmaceutical and agrochemical products. It is also used as an intermediate in the synthesis of other organic compounds, including dyes and pigments. Additionally, 2-(4-Fluoro-2-nitrophenyl)acetonitrile is known for its moderate toxicity and should be handled and used with caution.

Upstream product

• 61540-35-0 S-(Dimethylthiocarbamoyl)thioglycolonitrile 
• 402-67-5 3-fluoro-1-nitrobenzene 
• 7677-24-9 trimethylsilyl cyanide 
• 76437-44-0 1-(bromomethyl)-4-fluoro-2-nitrobenzene 
• 5367-32-8 5-methoxy-2-nitrotoluene 
• 67567-46-8 2‐(bromomethyl)‐4‐methoxy‐1‐nitrobenzene 
• 364-74-9 1,4-difluoro-2-nitrobenzene 
• 540-36-3 para-difluorobenzene 
• 107-14-2 chloroacetonitrile 
• 3598-14-9 phenoxyacetonitrile 
• 728-00-7 4-Fluor-2-nitro-α-cyan-phenylessigsaeure-aethylester 

Relevant articles and documents

Mn(III)-Mediated Radical Cyclization of o-Alkenyl Aromatic Isocyanides with Boronic Acids: Access to N-Unprotected 2-Aryl-3-cyanoindoles

The synthesis of N-unprotected 2-aryl-3-cyanoindoles was realized via the Mn(III)-mediated radical cascade cyclization of o-alkenyl aromatic isocyanides with boronic acids. A possible mechanism involving a sequential intermolecular radical addition, intramolecular cyclization, and cleavage of the C-C bond under mild reaction conditions is proposed. Mechanism studies show that H2O or O2 might provide the oxygen source for the elimination of benzaldehyde.

Synthesis of pyrazolo[1,5- c] quinazoline derivatives through the copper-catalyzed domino reaction of o -alkenyl aromatic isocyanides with diazo compounds

A novel copper-catalyzed domino reaction between o-alkenyl aromatic isocyanides and diazo compounds has been developed under mild reaction conditions. Various o-alkenyl aromatic isocyanides were prepared from readily available reactants. The reaction prov

Specific ortho-Cyanomethylation of Nitroarenes via the Vicarious Nucleophilic Substitution of Hydrogen

The vicarious nucleophilic substitution of hydrogen in nitroarenes with acetonitrile derivatives XCH2CN in t-BuOK/THF base/solvent system proceeds exclusively ortho to the nitro group.Strong influence of substituents Z in 3-Z-nitrobenzene derivatives on the orientation has been observed.